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Peripheral blood CD4 T-cell and plasmacytoid dendritic cell (pDC) reactivity to herpes simplex virus 2 and pDC number do not correlate with the clinical or virologic severity of recurrent genital herpes.

Moss NJ, Magaret A, Laing KJ, Kask AS, Wang M, Mark KE, Schiffer JT, Wald A, Koelle DM.

J Virol. 2012 Sep;86(18):9952-63. doi: 10.1128/JVI.00829-12. Epub 2012 Jul 3.


Virologic and immunologic evidence of multifocal genital herpes simplex virus 2 infection.

Johnston C, Zhu J, Jing L, Laing KJ, McClurkan CM, Klock A, Diem K, Jin L, Stanaway J, Tronstein E, Kwok WW, Huang ML, Selke S, Fong Y, Magaret A, Koelle DM, Wald A, Corey L.

J Virol. 2014 May;88(9):4921-31. doi: 10.1128/JVI.03285-13. Epub 2014 Feb 19.


Impact of asymptomatic herpes simplex virus type 2 infection on mucosal homing and immune cell subsets in the blood and female genital tract.

Shannon B, Yi TJ, Thomas-Pavanel J, Chieza L, Janakiram P, Saunders M, Tharao W, Huibner S, Remis R, Rebbapragada A, Kaul R.

J Immunol. 2014 Jun 1;192(11):5074-82. doi: 10.4049/jimmunol.1302916. Epub 2014 Apr 23.


Identification of novel virus-specific antigens by CD4⁺ and CD8⁺ T cells from asymptomatic HSV-2 seropositive and seronegative donors.

Long D, Skoberne M, Gierahn TM, Larson S, Price JA, Clemens V, Baccari AE, Cohane KP, Garvie D, Siber GR, Flechtner JB.

Virology. 2014 Sep;464-465:296-311. doi: 10.1016/j.virol.2014.07.018. Epub 2014 Aug 9.


T cell immunity to herpes simplex viruses in seronegative subjects: silent infection or acquired immunity?

Posavad CM, Wald A, Hosken N, Huang ML, Koelle DM, Ashley RL, Corey L.

J Immunol. 2003 Apr 15;170(8):4380-8.


Virus-specific immune memory at peripheral sites of herpes simplex virus type 2 (HSV-2) infection in guinea pigs.

Xia J, Veselenak RL, Gorder SR, Bourne N, Milligan GN.

PLoS One. 2014 Dec 8;9(12):e114652. doi: 10.1371/journal.pone.0114652. eCollection 2014 Dec 8.


Herpes simplex virus type 2 coinfection does not accelerate CD4 count decline in untreated HIV infection.

Tan DH, Raboud JM, Kaul R, Brunetta J, Kaushic C, Kovacs C, Lee E, Luetkehoelter J, Rachlis A, Smaill F, Smieja M, Walmsley SL.

Clin Infect Dis. 2013 Aug;57(3):448-57. doi: 10.1093/cid/cit208. Epub 2013 Apr 9.


Vaginal submucosal dendritic cells, but not Langerhans cells, induce protective Th1 responses to herpes simplex virus-2.

Zhao X, Deak E, Soderberg K, Linehan M, Spezzano D, Zhu J, Knipe DM, Iwasaki A.

J Exp Med. 2003 Jan 20;197(2):153-62.


Homing in on the cellular immune response to HSV-2 in humans.

Koelle DM, Gonzalez JC, Johnson AS.

Am J Reprod Immunol. 2005 Apr;53(4):172-81.


Persistence of mucosal T-cell responses to herpes simplex virus type 2 in the female genital tract.

Posavad CM, Zhao L, Mueller DE, Stevens CE, Huang ML, Wald A, Corey L.

Mucosal Immunol. 2015 Jan;8(1):115-26. doi: 10.1038/mi.2014.47. Epub 2014 Jun 11.


Mucosal host immune response predicts the severity and duration of herpes simplex virus-2 genital tract shedding episodes.

Schiffer JT, Abu-Raddad L, Mark KE, Zhu J, Selke S, Koelle DM, Wald A, Corey L.

Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18973-8. doi: 10.1073/pnas.1006614107. Epub 2010 Oct 18.


Plasmacytoid dendritic cells contribute to systemic but not local antiviral responses to HSV infections.

Swiecki M, Wang Y, Gilfillan S, Colonna M.

PLoS Pathog. 2013 Oct;9(10):e1003728. doi: 10.1371/journal.ppat.1003728. Epub 2013 Oct 24.


Herpes simplex virus-2 in the genital mucosa: insights into the mucosal host response and vaccine development.

Lee AJ, Ashkar AA.

Curr Opin Infect Dis. 2012 Feb;25(1):92-9. doi: 10.1097/QCO.0b013e32834e9a56. Review.


Role for plasmacytoid dendritic cells in the immune control of recurrent human herpes simplex virus infection.

Donaghy H, Bosnjak L, Harman AN, Marsden V, Tyring SK, Meng TC, Cunningham AL.

J Virol. 2009 Feb;83(4):1952-61. doi: 10.1128/JVI.01578-08. Epub 2008 Dec 10.


Genital shedding of herpes simplex virus among symptomatic and asymptomatic persons with HSV-2 infection.

Tronstein E, Johnston C, Huang ML, Selke S, Magaret A, Warren T, Corey L, Wald A.

JAMA. 2011 Apr 13;305(14):1441-9. doi: 10.1001/jama.2011.420.

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