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Items: 1 to 20 of 122

1.

Rescue of the aggregation prone Itk Pleckstrin Homology domain by two mutations derived from the related kinases, Btk and Tec.

Boyken SE, Fulton DB, Andreotti AH.

Protein Sci. 2012 Sep;21(9):1288-97. doi: 10.1002/pro.2114. Epub 2012 Jul 16.

2.

A conserved motif in the ITK PH-domain is required for phosphoinositide binding and TCR signaling but dispensable for adaptor protein interactions.

Hirve N, Levytskyy RM, Rigaud S, Guimond DM, Zal T, Sauer K, Tsoukas CD.

PLoS One. 2012;7(9):e45158. doi: 10.1371/journal.pone.0045158. Epub 2012 Sep 18.

3.

TEC family kinases in health and disease--loss-of-function of BTK and ITK and the gain-of-function fusions ITK-SYK and BTK-SYK.

Hussain A, Yu L, Faryal R, Mohammad DK, Mohamed AJ, Smith CI.

FEBS J. 2011 Jun;278(12):2001-10. doi: 10.1111/j.1742-4658.2011.08134.x. Epub 2011 May 18. Review.

4.
5.

A specific intermolecular association between the regulatory domains of a Tec family kinase.

Brazin KN, Fulton DB, Andreotti AH.

J Mol Biol. 2000 Sep 22;302(3):607-23.

PMID:
10986122
7.

Expression and function of Tec, Itk, and Btk in lymphocytes: evidence for a unique role for Tec.

Tomlinson MG, Kane LP, Su J, Kadlecek TA, Mollenauer MN, Weiss A.

Mol Cell Biol. 2004 Mar;24(6):2455-66.

8.

Activation loop dynamics determine the different catalytic efficiencies of B cell- and T cell-specific tec kinases.

Joseph RE, Kleino I, Wales TE, Xie Q, Fulton DB, Engen JR, Berg LJ, Andreotti AH.

Sci Signal. 2013 Aug 27;6(290):ra76. doi: 10.1126/scisignal.2004298.

9.

Substrate recognition of PLCγ1 via a specific docking surface on Itk.

Xie Q, Joseph RE, Fulton DB, Andreotti AH.

J Mol Biol. 2013 Feb 22;425(4):683-96. doi: 10.1016/j.jmb.2012.10.023. Epub 2012 Dec 3.

10.

Pleckstrin homology domains of tec family protein kinases.

Okoh MP, Vihinen M.

Biochem Biophys Res Commun. 1999 Nov;265(1):151-7.

PMID:
10548506
11.
13.

The lymphoma-associated fusion tyrosine kinase ITK-SYK requires pleckstrin homology domain-mediated membrane localization for activation and cellular transformation.

Rigby S, Huang Y, Streubel B, Chott A, Du MQ, Turner SD, Bacon CM.

J Biol Chem. 2009 Sep 25;284(39):26871-81. doi: 10.1074/jbc.M109.034272. Epub 2009 Jun 17.

14.

Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade.

Bunnell SC, Diehn M, Yaffe MB, Findell PR, Cantley LC, Berg LJ.

J Biol Chem. 2000 Jan 21;275(3):2219-30.

15.

Controlling the activity of the Tec kinase Itk by mutation of the phenylalanine gatekeeper residue.

Joseph RE, Andreotti AH.

Biochemistry. 2011 Jan 18;50(2):221-9. Epub 2010 Dec 16.

16.
17.

The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species.

Smith CI, Islam TC, Mattsson PT, Mohamed AJ, Nore BF, Vihinen M.

Bioessays. 2001 May;23(5):436-46. Review.

PMID:
11340625
18.

Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation.

Shan X, Czar MJ, Bunnell SC, Liu P, Liu Y, Schwartzberg PL, Wange RL.

Mol Cell Biol. 2000 Sep;20(18):6945-57.

19.

Biochemical and genetic analyses of the Tec kinases Itk and Rlk/Txk.

Czar MJ, Debnath J, Schaeffer EM, Lewis CM, Schwartzberg PL.

Biochem Soc Trans. 2001 Nov;29(Pt 6):863-7. Review.

PMID:
11709089
20.

Structure of the PH domain from Bruton's tyrosine kinase in complex with inositol 1,3,4,5-tetrakisphosphate.

Baraldi E, Djinovic Carugo K, Hyvönen M, Surdo PL, Riley AM, Potter BV, O'Brien R, Ladbury JE, Saraste M.

Structure. 1999 Apr 15;7(4):449-60.

PMID:
10196129
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