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Constitutive activity of TRPML2 and TRPML3 channels versus activation by low extracellular sodium and small molecules.

Grimm C, Jörs S, Guo Z, Obukhov AG, Heller S.

J Biol Chem. 2012 Jun 29;287(27):22701-8. doi: 10.1074/jbc.M112.368876.


TRPML2 and mucolipin evolution.

García-Añoveros J, Wiwatpanit T.

Handb Exp Pharmacol. 2014;222:647-58. doi: 10.1007/978-3-642-54215-2_25. Review.


Constitutive activity of the human TRPML2 channel induces cell degeneration.

Lev S, Zeevi DA, Frumkin A, Offen-Glasner V, Bach G, Minke B.

J Biol Chem. 2010 Jan 22;285(4):2771-82. doi: 10.1074/jbc.M109.046508. Epub 2009 Nov 23.


Lysosomal localization of TRPML3 depends on TRPML2 and the mucolipidosis-associated protein TRPML1.

Venkatachalam K, Hofmann T, Montell C.

J Biol Chem. 2006 Jun 23;281(25):17517-27. Epub 2006 Apr 10.


The mucolipin-2 (TRPML2) ion channel: a tissue-specific protein crucial to normal cell function.

Cuajungco MP, Silva J, Habibi A, Valadez JA.

Pflugers Arch. 2016 Feb;468(2):177-92. doi: 10.1007/s00424-015-1732-2. Epub 2015 Sep 4. Review.


Campaign to Identify Agonists of Transient Receptor Potential Channels 3 and 2 (TRPML3 & TRPML2).

Saldanha SA, Grimm C, Mercer BA, Choi JY, Allais C, Roush WR, Heller S, Hodder P.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2009 Nov 13 [updated 2011 May 5].


TRPML2 and the evolution of mucolipins.

Flores EN, García-Añoveros J.

Adv Exp Med Biol. 2011;704:221-8. doi: 10.1007/978-94-007-0265-3_12. Review.


Small molecule activators of TRPML3.

Grimm C, Jörs S, Saldanha SA, Obukhov AG, Pan B, Oshima K, Cuajungco MP, Chase P, Hodder P, Heller S.

Chem Biol. 2010 Feb 26;17(2):135-48. doi: 10.1016/j.chembiol.2009.12.016.


Emerging issues of connexin channels: biophysics fills the gap.

Harris AL.

Q Rev Biophys. 2001 Aug;34(3):325-472. Review. Erratum in: Q Rev Biophys 2002 Feb;35(1):109.


A novel extracellular calcium sensing mechanism in voltage-gated potassium ion channels.

Johnson JP Jr, Balser JR, Bennett PB.

J Neurosci. 2001 Jun 15;21(12):4143-53.


Role of TRPML and two-pore channels in endolysosomal cation homeostasis.

Grimm C, Hassan S, Wahl-Schott C, Biel M.

J Pharmacol Exp Ther. 2012 Aug;342(2):236-44. doi: 10.1124/jpet.112.192880. Epub 2012 Apr 19.


The tissue-specific expression of TRPML2 (MCOLN-2) gene is influenced by the presence of TRPML1.

Samie MA, Grimm C, Evans JA, Curcio-Morelli C, Heller S, Slaugenhaupt SA, Cuajungco MP.

Pflugers Arch. 2009 Nov;459(1):79-91. doi: 10.1007/s00424-009-0716-5.


A novel ion channel formed by interaction of TRPML3 with TRPV5.

Guo Z, Grimm C, Becker L, Ricci AJ, Heller S.

PLoS One. 2013;8(2):e58174. doi: 10.1371/journal.pone.0058174. Epub 2013 Feb 28.


Extracellular ATP directly gates a cation-selective channel in rabbit airway ciliated epithelial cells.

Korngreen A, Ma W, Priel Z, Silberberg SD.

J Physiol. 1998 May 1;508 ( Pt 3):703-20.


Structural modeling and patch-clamp analysis of pain-related mutation TRPA1-N855S reveal inter-subunit salt bridges stabilizing the channel open state.

Zíma V, Witschas K, Hynkova A, Zímová L, Barvík I, Vlachova V.

Neuropharmacology. 2015 Jun;93:294-307. doi: 10.1016/j.neuropharm.2015.02.018. Epub 2015 Feb 25.


Drosophila TRPML forms PI(3,5)P2-activated cation channels in both endolysosomes and plasma membrane.

Feng X, Huang Y, Lu Y, Xiong J, Wong CO, Yang P, Xia J, Chen D, Du G, Venkatachalam K, Xia X, Zhu MX.

J Biol Chem. 2014 Feb 14;289(7):4262-72. doi: 10.1074/jbc.M113.506501. Epub 2013 Dec 27.


Acid-sensing ion channels contribute to transduction of extracellular acidosis in rat carotid body glomus cells.

Tan ZY, Lu Y, Whiteis CA, Benson CJ, Chapleau MW, Abboud FM.

Circ Res. 2007 Nov 9;101(10):1009-19. Epub 2007 Sep 13.


A novel mode of TRPML3 regulation by extracytosolic pH absent in the varitint-waddler phenotype.

Kim HJ, Li Q, Tjon-Kon-Sang S, So I, Kiselyov K, Soyombo AA, Muallem S.

EMBO J. 2008 Apr 23;27(8):1197-205. doi: 10.1038/emboj.2008.56. Epub 2008 Mar 27.


Gain-of-function mutation in TRPML3 causes the mouse Varitint-Waddler phenotype.

Kim HJ, Li Q, Tjon-Kon-Sang S, So I, Kiselyov K, Muallem S.

J Biol Chem. 2007 Dec 14;282(50):36138-42. Epub 2007 Oct 25.

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