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Items: 1 to 20 of 149


Thoracic aortic aneurysm (TAAD)-causing mutation in actin affects formin regulation of polymerization.

Malloy LE, Wen KK, Pierick AR, Wedemeyer EW, Bergeron SE, Vanderpool ND, McKane M, Rubenstein PA, Bartlett HL.

J Biol Chem. 2012 Aug 17;287(34):28398-408. doi: 10.1074/jbc.M112.371914. Epub 2012 Jun 29.


Importance of a Lys113-Glu195 intermonomer ionic bond in F-actin stabilization and regulation by yeast formins Bni1p and Bnr1p.

Wen KK, McKane M, Rubenstein PA.

J Biol Chem. 2013 Jun 28;288(26):19140-53. doi: 10.1074/jbc.M113.474122. Epub 2013 May 7.


Differential regulation of actin polymerization and structure by yeast formin isoforms.

Wen KK, Rubenstein PA.

J Biol Chem. 2009 Jun 19;284(25):16776-83. doi: 10.1074/jbc.M109.006981. Epub 2009 Apr 22.


Allele-specific effects of thoracic aortic aneurysm and dissection alpha-smooth muscle actin mutations on actin function.

Bergeron SE, Wedemeyer EW, Lee R, Wen KK, McKane M, Pierick AR, Berger AP, Rubenstein PA, Bartlett HL.

J Biol Chem. 2011 Apr 1;286(13):11356-69. doi: 10.1074/jbc.M110.203174. Epub 2011 Feb 2.


Electrostatic interactions between the Bni1p Formin FH2 domain and actin influence actin filament nucleation.

Baker JL, Courtemanche N, Parton DL, McCullagh M, Pollard TD, Voth GA.

Structure. 2015 Jan 6;23(1):68-79. doi: 10.1016/j.str.2014.10.014. Epub 2014 Dec 4.


Mutations to the formin homology 2 domain of INF2 protein have unexpected effects on actin polymerization and severing.

Ramabhadran V, Gurel PS, Higgs HN.

J Biol Chem. 2012 Oct 5;287(41):34234-45. doi: 10.1074/jbc.M112.365122. Epub 2012 Aug 9.


Determinants of Formin Homology 1 (FH1) domain function in actin filament elongation by formins.

Courtemanche N, Pollard TD.

J Biol Chem. 2012 Mar 2;287(10):7812-20. doi: 10.1074/jbc.M111.322958. Epub 2012 Jan 14.


Mutant profilin suppresses mutant actin-dependent mitochondrial phenotype in Saccharomyces cerevisiae.

Wen KK, McKane M, Stokasimov E, Rubenstein PA.

J Biol Chem. 2011 Dec 2;286(48):41745-57. doi: 10.1074/jbc.M110.217661. Epub 2011 Sep 28. Erratum in: J Biol Chem. 2012 Apr 13;287(16):13048.


Structural basis of actin filament nucleation and processive capping by a formin homology 2 domain.

Otomo T, Tomchick DR, Otomo C, Panchal SC, Machius M, Rosen MK.

Nature. 2005 Feb 3;433(7025):488-94. Epub 2005 Jan 5.


Mechanism of formin-induced nucleation of actin filaments.

Pring M, Evangelista M, Boone C, Yang C, Zigmond SH.

Biochemistry. 2003 Jan 21;42(2):486-96.


The role of the FH1 domain and profilin in formin-mediated actin-filament elongation and nucleation.

Paul AS, Pollard TD.

Curr Biol. 2008 Jan 8;18(1):9-19. Epub 2007 Dec 20. Erratum in: Curr Biol. 2008 Feb 12;18(3):233. Paul, Aditya [corrected to Paul, Aditya S]; Pollard, Thomas [corrected to Pollard, Thomas D].


Actin polymerization upon processive capping by formin: a model for slowing and acceleration.

Shemesh T, Kozlov MM.

Biophys J. 2007 Mar 1;92(5):1512-21. Epub 2006 Dec 8.


Analysis of unregulated formin activity reveals how yeast can balance F-actin assembly between different microfilament-based organizations.

Gao L, Bretscher A.

Mol Biol Cell. 2008 Apr;19(4):1474-84. doi: 10.1091/mbc.E07-05-0520. Epub 2008 Jan 30.


Structure of a Bud6/Actin Complex Reveals a Novel WH2-like Actin Monomer Recruitment Motif.

Park E, Graziano BR, Zheng W, Garabedian M, Goode BL, Eck MJ.

Structure. 2015 Aug 4;23(8):1492-9. doi: 10.1016/j.str.2015.05.015. Epub 2015 Jun 25.


Aip1p dynamics are altered by the R256H mutation in actin.

Pierick AR, McKane M, Wen KK, Bartlett HL.

J Vis Exp. 2014 Jul 30;(89):e51551. doi: 10.3791/51551.


Tension modulates actin filament polymerization mediated by formin and profilin.

Courtemanche N, Lee JY, Pollard TD, Greene EC.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9752-7. doi: 10.1073/pnas.1308257110. Epub 2013 May 28.


The fission yeast cytokinesis formin Cdc12p is a barbed end actin filament capping protein gated by profilin.

Kovar DR, Kuhn JR, Tichy AL, Pollard TD.

J Cell Biol. 2003 Jun 9;161(5):875-87.


Structure of the formin-interaction domain of the actin nucleation-promoting factor Bud6.

Tu D, Graziano BR, Park E, Zheng W, Li Y, Goode BL, Eck MJ.

Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):E3424-33. doi: 10.1073/pnas.1203035109. Epub 2012 Nov 16.


Severe Molecular Defects Exhibited by the R179H Mutation in Human Vascular Smooth Muscle α-Actin.

Lu H, Fagnant PM, Krementsova EB, Trybus KM.

J Biol Chem. 2016 Oct 7;291(41):21729-21739. Epub 2016 Aug 22.

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