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CHK1 activity is required for continuous replication fork elongation but not stabilization of post-replicative gaps after UV irradiation.

Elvers I, Hagenkort A, Johansson F, Djureinovic T, Lagerqvist A, Schultz N, Stoimenov I, Erixon K, Helleday T.

Nucleic Acids Res. 2012 Sep 1;40(17):8440-8. Epub 2012 Jun 29.


Gap-filling and bypass at the replication fork are both active mechanisms for tolerance of low-dose ultraviolet-induced DNA damage in the human genome.

Quinet A, Vessoni AT, Rocha CR, Gottifredi V, Biard D, Sarasin A, Menck CF, Stary A.

DNA Repair (Amst). 2014 Feb;14:27-38. doi: 10.1016/j.dnarep.2013.12.005. Epub 2013 Dec 28.


ATR/Chk1 pathway is essential for resumption of DNA synthesis and cell survival in UV-irradiated XP variant cells.

Despras E, Daboussi F, Hyrien O, Marheineke K, Kannouche PL.

Hum Mol Genet. 2010 May 1;19(9):1690-701. doi: 10.1093/hmg/ddq046. Epub 2010 Feb 1.


Kinase-independent function of checkpoint kinase 1 (Chk1) in the replication of damaged DNA.

Speroni J, Federico MB, Mansilla SF, Soria G, Gottifredi V.

Proc Natl Acad Sci U S A. 2012 May 8;109(19):7344-9. doi: 10.1073/pnas.1116345109. Epub 2012 Apr 23.


Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1.

Krause DR, Jonnalagadda JC, Gatei MH, Sillje HH, Zhou BB, Nigg EA, Khanna K.

Oncogene. 2003 Sep 4;22(38):5927-37.


Chk1 inhibition after replicative stress activates a double strand break response mediated by ATM and DNA-dependent protein kinase.

McNeely S, Conti C, Sheikh T, Patel H, Zabludoff S, Pommier Y, Schwartz G, Tse A.

Cell Cycle. 2010 Mar 1;9(5):995-1004. Epub 2010 Mar 14.


UV-induced G2 checkpoint depends on p38 MAPK and minimal activation of ATR-Chk1 pathway.

Warmerdam DO, Brinkman EK, Marteijn JA, Medema RH, Kanaar R, Smits VA.

J Cell Sci. 2013 May 1;126(Pt 9):1923-30. doi: 10.1242/jcs.118265. Epub 2013 Feb 27.


Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories.

Ge XQ, Blow JJ.

J Cell Biol. 2010 Dec 27;191(7):1285-97. doi: 10.1083/jcb.201007074. Epub 2010 Dec 20.


Menin localizes to chromatin through an ATR-CHK1 mediated pathway after UV-induced DNA damage.

Farley SM, Chen G, Guo S, Wang M, A J, Lee F, Lee F, Sawicki M.

J Surg Res. 2006 Jun 1;133(1):29-37.


UV stalled replication forks restart by re-priming in human fibroblasts.

Elvers I, Johansson F, Groth P, Erixon K, Helleday T.

Nucleic Acids Res. 2011 Sep 1;39(16):7049-57. doi: 10.1093/nar/gkr420. Epub 2011 Jun 6.


The fork and the kinase: a DNA replication tale from a CHK1 perspective.

González Besteiro MA, Gottifredi V.

Mutat Res Rev Mutat Res. 2015 Jan-Mar;763:168-80. doi: 10.1016/j.mrrev.2014.10.003. Epub 2014 Oct 22. Review.


Inhibition of human Chk1 causes increased initiation of DNA replication, phosphorylation of ATR targets, and DNA breakage.

Syljuåsen RG, Sørensen CS, Hansen LT, Fugger K, Lundin C, Johansson F, Helleday T, Sehested M, Lukas J, Bartek J.

Mol Cell Biol. 2005 May;25(9):3553-62.


The human Tim/Tipin complex coordinates an Intra-S checkpoint response to UV that slows replication fork displacement.

Unsal-Kaçmaz K, Chastain PD, Qu PP, Minoo P, Cordeiro-Stone M, Sancar A, Kaufmann WK.

Mol Cell Biol. 2007 Apr;27(8):3131-42. Epub 2007 Feb 12.


Chk1- and claspin-dependent but ATR/ATM- and Rad17-independent DNA replication checkpoint response in HeLa cells.

Rodríguez-Bravo V, Guaita-Esteruelas S, Florensa R, Bachs O, Agell N.

Cancer Res. 2006 Sep 1;66(17):8672-9.


UV-induced RPA phosphorylation is increased in the absence of DNA polymerase eta and requires DNA-PK.

Cruet-Hennequart S, Coyne S, Glynn MT, Oakley GG, Carty MP.

DNA Repair (Amst). 2006 Apr 8;5(4):491-504. Epub 2006 Mar 7.


Preclinical development of the novel Chk1 inhibitor SCH900776 in combination with DNA-damaging agents and antimetabolites.

Montano R, Chung I, Garner KM, Parry D, Eastman A.

Mol Cancer Ther. 2012 Feb;11(2):427-38. doi: 10.1158/1535-7163.MCT-11-0406. Epub 2011 Dec 27.


UV-induced ataxia-telangiectasia-mutated and Rad3-related (ATR) activation requires replication stress.

Ward IM, Minn K, Chen J.

J Biol Chem. 2004 Mar 12;279(11):9677-80. Epub 2004 Jan 23.


Carcinogen-induced S-phase arrest is Chk1 mediated and caffeine sensitive.

Guo N, Faller DV, Vaziri C.

Cell Growth Differ. 2002 Feb;13(2):77-86.


Polymerase eta and p53 jointly regulate cell survival, apoptosis and Mre11 recombination during S phase checkpoint arrest after UV irradiation.

Cleaver JE, Bartholomew J, Char D, Crowley E, Feeney L, Limoli CL.

DNA Repair (Amst). 2002 Jan 22;1(1):41-57.


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