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Regulation of the transient receptor potential channel TRPA1 by its N-terminal ankyrin repeat domain.

Zayats V, Samad A, Minofar B, Roelofs KE, Stockner T, Ettrich R.

J Mol Model. 2013 Nov;19(11):4689-700. doi: 10.1007/s00894-012-1505-1.


Structural modeling and patch-clamp analysis of pain-related mutation TRPA1-N855S reveal inter-subunit salt bridges stabilizing the channel open state.

Zíma V, Witschas K, Hynkova A, Zímová L, Barvík I, Vlachova V.

Neuropharmacology. 2015 Jun;93:294-307. doi: 10.1016/j.neuropharm.2015.02.018.


Human TRPA1 is intrinsically cold- and chemosensitive with and without its N-terminal ankyrin repeat domain.

Moparthi L, Survery S, Kreir M, Simonsen C, Kjellbom P, Högestätt ED, Johanson U, Zygmunt PM.

Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16901-6. doi: 10.1073/pnas.1412689111.


Irritating channels: the case of TRPA1.

Nilius B, Prenen J, Owsianik G.

J Physiol. 2011 Apr 1;589(Pt 7):1543-9. doi: 10.1113/jphysiol.2010.200717. Review.


C-terminal acidic cluster is involved in Ca2+-induced regulation of human transient receptor potential ankyrin 1 channel.

Sura L, Zíma V, Marsakova L, Hynkova A, Barvík I, Vlachova V.

J Biol Chem. 2012 May 25;287(22):18067-77. doi: 10.1074/jbc.M112.341859.



García-Añoveros J, Nagata K.

Handb Exp Pharmacol. 2007;(179):347-62. Review.


Modulation of transient receptor vanilloid 1 activity by transient receptor potential ankyrin 1.

Spahn V, Stein C, Zöllner C.

Mol Pharmacol. 2014 Feb;85(2):335-44. doi: 10.1124/mol.113.088997.


Direct activation of the ion channel TRPA1 by Ca2+.

Zurborg S, Yurgionas B, Jira JA, Caspani O, Heppenstall PA.

Nat Neurosci. 2007 Mar;10(3):277-9.


The C-terminal basic residues contribute to the chemical- and voltage-dependent activation of TRPA1.

Samad A, Sura L, Benedikt J, Ettrich R, Minofar B, Teisinger J, Vlachova V.

Biochem J. 2011 Jan 1;433(1):197-204. doi: 10.1042/BJ20101256.


The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ions.

Wang YY, Chang RB, Waters HN, McKemy DD, Liman ER.

J Biol Chem. 2008 Nov 21;283(47):32691-703. doi: 10.1074/jbc.M803568200.


Characterization of a ligand binding site in the human transient receptor potential ankyrin 1 pore.

Klement G, Eisele L, Malinowsky D, Nolting A, Svensson M, Terp G, Weigelt D, Dabrowski M.

Biophys J. 2013 Feb 19;104(4):798-806. doi: 10.1016/j.bpj.2013.01.008.


Activation characteristics of transient receptor potential ankyrin 1 and its role in nociception.

Raisinghani M, Zhong L, Jeffry JA, Bishnoi M, Pabbidi RM, Pimentel F, Cao DS, Evans MS, Premkumar LS.

Am J Physiol Cell Physiol. 2011 Sep;301(3):C587-600. doi: 10.1152/ajpcell.00465.2010.


Molecular basis determining inhibition/activation of nociceptive receptor TRPA1 protein: a single amino acid dictates species-specific actions of the most potent mammalian TRPA1 antagonist.

Banzawa N, Saito S, Imagawa T, Kashio M, Takahashi K, Tominaga M, Ohta T.

J Biol Chem. 2014 Nov 14;289(46):31927-39. doi: 10.1074/jbc.M114.586891.


The TRPA1 channel in inflammatory and neuropathic pain and migraine.

Nassini R, Materazzi S, Benemei S, Geppetti P.

Rev Physiol Biochem Pharmacol. 2014;167:1-43. doi: 10.1007/112_2014_18. Review.


Structure of the TRPA1 ion channel suggests regulatory mechanisms.

Paulsen CE, Armache JP, Gao Y, Cheng Y, Julius D.

Nature. 2015 Apr 23;520(7548):511-7. doi: 10.1038/nature14367. Erratum in: Nature. 2015 Sep 24;525(7570):552.


A primer on ankyrin repeat function in TRP channels and beyond.

Gaudet R.

Mol Biosyst. 2008 May;4(5):372-9. doi: 10.1039/b801481g. Review.


Activation of Transient Receptor Potential Ankyrin-1 by Insoluble Particulate Material and Association with Asthma.

Deering-Rice CE, Shapiro D, Romero EG, Stockmann C, Bevans TS, Phan QM, Stone BL, Fassl B, Nkoy F, Uchida DA, Ward RM, Veranth JM, Reilly CA.

Am J Respir Cell Mol Biol. 2015 Dec;53(6):893-901. doi: 10.1165/rcmb.2015-0086OC.


Genetic variants affecting human TRPA1 or TRPM8 structure can be classified in vitro as 'well expressed', 'poorly expressed' or 'salvageable'.

Morgan K, Sadofsky LR, Morice AH.

Biosci Rep. 2015 Sep 1;35(5). pii: e00255. doi: 10.1042/BSR20150108.


Transient receptor potential ankyrin 1 channel localized to non-neuronal airway cells promotes non-neurogenic inflammation.

Nassini R, Pedretti P, Moretto N, Fusi C, Carnini C, Facchinetti F, Viscomi AR, Pisano AR, Stokesberry S, Brunmark C, Svitacheva N, McGarvey L, Patacchini R, Damholt AB, Geppetti P, Materazzi S.

PLoS One. 2012;7(8):e42454. doi: 10.1371/journal.pone.0042454.


Transient receptor potential channel A1 is directly gated by calcium ions.

Doerner JF, Gisselmann G, Hatt H, Wetzel CH.

J Biol Chem. 2007 May 4;282(18):13180-9.

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