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RAS, cellular senescence and transformation: the BRCA1 DNA repair pathway at the crossroads.

Tu Z, Aird KM, Zhang R.

Small GTPases. 2012 Jul-Sep;3(3):163-7. doi: 10.4161/sgtp.19884. Epub 2012 Jul 1.


Oncogenic RAS regulates BRIP1 expression to induce dissociation of BRCA1 from chromatin, inhibit DNA repair, and promote senescence.

Tu Z, Aird KM, Bitler BG, Nicodemus JP, Beeharry N, Xia B, Yen TJ, Zhang R.

Dev Cell. 2011 Dec 13;21(6):1077-91. doi: 10.1016/j.devcel.2011.10.010. Epub 2011 Dec 1.


BRG1 is required for formation of senescence-associated heterochromatin foci induced by oncogenic RAS or BRCA1 loss.

Tu Z, Zhuang X, Yao YG, Zhang R.

Mol Cell Biol. 2013 May;33(9):1819-29. doi: 10.1128/MCB.01744-12. Epub 2013 Feb 25.


Differential oncogenic Ras signaling and senescence in tumor cells.

Bihani T, Mason DX, Jackson TJ, Chen SC, Boettner B, Lin AW.

Cell Cycle. 2004 Sep;3(9):1201-7. Epub 2004 Sep 5.


Depletion of ERK2 but not ERK1 abrogates oncogenic Ras-induced senescence.

Shin J, Yang J, Lee JC, Baek KH.

Cell Signal. 2013 Dec;25(12):2540-7. doi: 10.1016/j.cellsig.2013.08.014. Epub 2013 Aug 30.


High intensity ras signaling induces premature senescence by activating p38 pathway in primary human fibroblasts.

Deng Q, Liao R, Wu BL, Sun P.

J Biol Chem. 2004 Jan 9;279(2):1050-9. Epub 2003 Oct 29.


JMJD2A promotes cellular transformation by blocking cellular senescence through transcriptional repression of the tumor suppressor CHD5.

Mallette FA, Richard S.

Cell Rep. 2012 Nov 29;2(5):1233-43. doi: 10.1016/j.celrep.2012.09.033. Epub 2012 Nov 15.


The miR-17-92 cluster of microRNAs confers tumorigenicity by inhibiting oncogene-induced senescence.

Hong L, Lai M, Chen M, Xie C, Liao R, Kang YJ, Xiao C, Hu WY, Han J, Sun P.

Cancer Res. 2010 Nov 1;70(21):8547-57. doi: 10.1158/0008-5472.CAN-10-1938. Epub 2010 Sep 17.


Tumor suppressor activity of the ERK/MAPK pathway by promoting selective protein degradation.

Deschênes-Simard X, Gaumont-Leclerc MF, Bourdeau V, Lessard F, Moiseeva O, Forest V, Igelmann S, Mallette FA, Saba-El-Leil MK, Meloche S, Saad F, Mes-Masson AM, Ferbeyre G.

Genes Dev. 2013 Apr 15;27(8):900-15. doi: 10.1101/gad.203984.112. Epub 2013 Apr 18.


PRAK is essential for ras-induced senescence and tumor suppression.

Sun P, Yoshizuka N, New L, Moser BA, Li Y, Liao R, Xie C, Chen J, Deng Q, Yamout M, Dong MQ, Frangou CG, Yates JR 3rd, Wright PE, Han J.

Cell. 2007 Jan 26;128(2):295-308.


An Arf-Egr-C/EBPβ pathway linked to ras-induced senescence and cancer.

Salotti J, Sakchaisri K, Tourtellotte WG, Johnson PF.

Mol Cell Biol. 2015 Mar;35(5):866-83. doi: 10.1128/MCB.01489-14. Epub 2014 Dec 22.


Attenuation of TGF-β signaling suppresses premature senescence in a p21-dependent manner and promotes oncogenic Ras-mediated metastatic transformation in human mammary epithelial cells.

Lin S, Yang J, Elkahloun AG, Bandyopadhyay A, Wang L, Cornell JE, Yeh IT, Agyin J, Tomlinson G, Sun LZ.

Mol Biol Cell. 2012 Apr;23(8):1569-81. doi: 10.1091/mbc.E11-10-0849. Epub 2012 Feb 22.


Oncogenic ras and p53 cooperate to induce cellular senescence.

Ferbeyre G, de Stanchina E, Lin AW, Querido E, McCurrach ME, Hannon GJ, Lowe SW.

Mol Cell Biol. 2002 May;22(10):3497-508.


Sequential inductions of the ZEB1 transcription factor caused by mutation of Rb and then Ras proteins are required for tumor initiation and progression.

Liu Y, Sánchez-Tilló E, Lu X, Huang L, Clem B, Telang S, Jenson AB, Cuatrecasas M, Chesney J, Postigo A, Dean DC.

J Biol Chem. 2013 Apr 19;288(16):11572-80. doi: 10.1074/jbc.M112.434951. Epub 2013 Feb 26.


Ras-induced senescence and its physiological relevance in cancer.

Dimauro T, David G.

Curr Cancer Drug Targets. 2010 Dec;10(8):869-76. Review.


The ability of E1A to rescue ras-induced premature senescence and confer transformation relies on inactivation of both p300/CBP and Rb family proteins.

Deng Q, Li Y, Tedesco D, Liao R, Fuhrmann G, Sun P.

Cancer Res. 2005 Sep 15;65(18):8298-307. Erratum in: Cancer Res. 2005 Nov 15;65(22):10635.


p38alpha and p38gamma mediate oncogenic ras-induced senescence through differential mechanisms.

Kwong J, Hong L, Liao R, Deng Q, Han J, Sun P.

J Biol Chem. 2009 Apr 24;284(17):11237-46. doi: 10.1074/jbc.M808327200. Epub 2009 Feb 27.


Attenuation of TORC1 signaling delays replicative and oncogenic RAS-induced senescence.

Kolesnichenko M, Hong L, Liao R, Vogt PK, Sun P.

Cell Cycle. 2012 Jun 15;11(12):2391-401. doi: 10.4161/cc.20683. Epub 2012 Jun 15.


Protein kinase D1 is essential for Ras-induced senescence and tumor suppression by regulating senescence-associated inflammation.

Wang P, Han L, Shen H, Wang P, Lv C, Zhao G, Niu J, Xue L, Wang QJ, Tong T, Chen J.

Proc Natl Acad Sci U S A. 2014 May 27;111(21):7683-8. doi: 10.1073/pnas.1310972111. Epub 2014 May 14.

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