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Mithramycin represses basal and cigarette smoke-induced expression of ABCG2 and inhibits stem cell signaling in lung and esophageal cancer cells.

Zhang M, Mathur A, Zhang Y, Xi S, Atay S, Hong JA, Datrice N, Upham T, Kemp CD, Ripley RT, Wiegand G, Avital I, Fetsch P, Mani H, Zlott D, Robey R, Bates SE, Li X, Rao M, Schrump DS.

Cancer Res. 2012 Aug 15;72(16):4178-92. doi: 10.1158/0008-5472.CAN-11-3983. Epub 2012 Jul 2.


Cigarette smoke promotes drug resistance and expansion of cancer stem cell-like side population.

An Y, Kiang A, Lopez JP, Kuo SZ, Yu MA, Abhold EL, Chen JS, Wang-Rodriguez J, Ongkeko WM.

PLoS One. 2012;7(11):e47919. doi: 10.1371/journal.pone.0047919. Epub 2012 Nov 5.


Transcription factors Sp1 and Sp3 regulate expression of human ABCG2 gene and chemoresistance phenotype.

Yang WJ, Song MJ, Park EY, Lee JJ, Park JH, Park K, Park JH, Kim HP.

Mol Cells. 2013 Oct;36(4):368-75. doi: 10.1007/s10059-013-0191-x. Epub 2013 Aug 29.


Afatinib enhances the efficacy of conventional chemotherapeutic agents by eradicating cancer stem-like cells.

Wang XK, He JH, Xu JH, Ye S, Wang F, Zhang H, Huang ZC, To KK, Fu LW.

Cancer Res. 2014 Aug 15;74(16):4431-45. doi: 10.1158/0008-5472.CAN-13-3553. Epub 2014 Jun 27.


Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2- cancer cells are similarly tumorigenic.

Patrawala L, Calhoun T, Schneider-Broussard R, Zhou J, Claypool K, Tang DG.

Cancer Res. 2005 Jul 15;65(14):6207-19.


Constitutive AhR activation leads to concomitant ABCG2-mediated multidrug resistance in cisplatin-resistant esophageal carcinoma cells.

To KK, Yu L, Liu S, Fu J, Cho CH.

Mol Carcinog. 2012 Jun;51(6):449-64. doi: 10.1002/mc.20810. Epub 2011 Jun 15.


Expressions of putative cancer stem cell markers ABCB1, ABCG2, and CD133 are correlated with the degree of differentiation of gastric cancer.

Jiang Y, He Y, Li H, Li HN, Zhang L, Hu W, Sun YM, Chen FL, Jin XM.

Gastric Cancer. 2012 Oct;15(4):440-50. doi: 10.1007/s10120-012-0140-y. Epub 2012 Feb 14.


Dietary compound isoliquiritigenin targets GRP78 to chemosensitize breast cancer stem cells via β-catenin/ABCG2 signaling.

Wang N, Wang Z, Peng C, You J, Shen J, Han S, Chen J.

Carcinogenesis. 2014 Nov;35(11):2544-54. doi: 10.1093/carcin/bgu187. Epub 2014 Sep 6.


Low molecular weight heparin ablates lung cancer cisplatin-resistance by inducing proteasome-mediated ABCG2 protein degradation.

Niu Q, Wang W, Li Y, Ruden DM, Wang F, Li Y, Wang F, Song J, Zheng K.

PLoS One. 2012;7(7):e41035. doi: 10.1371/journal.pone.0041035. Epub 2012 Jul 23.


Expression of ABCG2 (BCRP) is regulated by Nrf2 in cancer cells that confers side population and chemoresistance phenotype.

Singh A, Wu H, Zhang P, Happel C, Ma J, Biswal S.

Mol Cancer Ther. 2010 Aug;9(8):2365-76. doi: 10.1158/1535-7163.MCT-10-0108. Epub 2010 Aug 3.


Sonic hedgehog-glioma associated oncogene homolog 1 signaling enhances drug resistance in CD44(+)/Musashi-1(+) gastric cancer stem cells.

Xu M, Gong A, Yang H, George SK, Jiao Z, Huang H, Jiang X, Zhang Y.

Cancer Lett. 2015 Dec 1;369(1):124-33. doi: 10.1016/j.canlet.2015.08.005. Epub 2015 Aug 11.


Lapatinib (Tykerb, GW572016) reverses multidrug resistance in cancer cells by inhibiting the activity of ATP-binding cassette subfamily B member 1 and G member 2.

Dai CL, Tiwari AK, Wu CP, Su XD, Wang SR, Liu DG, Ashby CR Jr, Huang Y, Robey RW, Liang YJ, Chen LM, Shi CJ, Ambudkar SV, Chen ZS, Fu LW.

Cancer Res. 2008 Oct 1;68(19):7905-14. doi: 10.1158/0008-5472.CAN-08-0499. Erratum in: Cancer Res. 2008 Dec 15;68(24):10387.


Stem cell-like side populations in esophageal cancer: a source of chemotherapy resistance and metastases.

Zhao Y, Bao Q, Schwarz B, Zhao L, Mysliwietz J, Ellwart J, Renner A, Hirner H, Niess H, Camaj P, Angele M, Gros S, Izbicki J, Jauch KW, Nelson PJ, Bruns CJ.

Stem Cells Dev. 2014 Jan 15;23(2):180-92. doi: 10.1089/scd.2013.0103. Epub 2013 Nov 13.


Upregulation of ABCG2 by romidepsin via the aryl hydrocarbon receptor pathway.

To KK, Robey R, Zhan Z, Bangiolo L, Bates SE.

Mol Cancer Res. 2011 Apr;9(4):516-27. doi: 10.1158/1541-7786.MCR-10-0270. Epub 2011 Feb 25.


A novel xenobiotic responsive element regulated by aryl hydrocarbon receptor is involved in the induction of BCRP/ABCG2 in LS174T cells.

Tompkins LM, Li H, Li L, Lynch C, Xie Y, Nakanishi T, Ross DD, Wang H.

Biochem Pharmacol. 2010 Dec 1;80(11):1754-61. doi: 10.1016/j.bcp.2010.08.016. Epub 2010 Sep 9.


The combination of stem cell markers CD133 and ABCG2 predicts relapse in stage I non-small cell lung carcinomas.

Li F, Zeng H, Ying K.

Med Oncol. 2011 Dec;28(4):1458-62. doi: 10.1007/s12032-010-9646-5. Epub 2010 Aug 18.


Cigarette smoke mediates epigenetic repression of miR-487b during pulmonary carcinogenesis.

Xi S, Xu H, Shan J, Tao Y, Hong JA, Inchauste S, Zhang M, Kunst TF, Mercedes L, Schrump DS.

J Clin Invest. 2013 Mar;123(3):1241-61. doi: 10.1172/JCI61271. Epub 2013 Feb 15.


Guanosine-induced decrease in side population of lung cancer cells: lack of correlation with ABCG2 expression.

Su C, Picard P, Rathbone MP, Jiang S.

J Biol Regul Homeost Agents. 2010 Jan-Mar;24(1):19-25.


Dofequidar fumarate sensitizes cancer stem-like side population cells to chemotherapeutic drugs by inhibiting ABCG2/BCRP-mediated drug export.

Katayama R, Koike S, Sato S, Sugimoto Y, Tsuruo T, Fujita N.

Cancer Sci. 2009 Nov;100(11):2060-8. doi: 10.1111/j.1349-7006.2009.01288.x. Epub 2009 Jul 17.


Reduced SLC27A2 induces cisplatin resistance in lung cancer stem cells by negatively regulating Bmi1-ABCG2 signaling.

Su J, Wu S, Tang W, Qian H, Zhou H, Guo T.

Mol Carcinog. 2016 Nov;55(11):1822-1832. doi: 10.1002/mc.22430. Epub 2015 Oct 29.


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