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Crystallization and preliminary crystallographic studies of CCM3 in complex with the C-terminal domain of MST4.

Xu X, Wang X, Ding J, Wang DC.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Jul 1;68(Pt 7):760-3. doi: 10.1107/S1744309112016843. Epub 2012 Jun 27.


Structural mechanism of CCM3 heterodimerization with GCKIII kinases.

Zhang M, Dong L, Shi Z, Jiao S, Zhang Z, Zhang W, Liu G, Chen C, Feng M, Hao Q, Wang W, Yin M, Zhao Y, Zhang L, Zhou Z.

Structure. 2013 Apr 2;21(4):680-8.


CCM3/PDCD10 heterodimerizes with germinal center kinase III (GCKIII) proteins using a mechanism analogous to CCM3 homodimerization.

Ceccarelli DF, Laister RC, Mulligan VK, Kean MJ, Goudreault M, Scott IC, Derry WB, Chakrabartty A, Gingras AC, Sicheri F.

J Biol Chem. 2011 Jul 15;286(28):25056-64. doi: 10.1074/jbc.M110.213777. Epub 2011 May 11.


Functional analyses of human and zebrafish 18-amino acid in-frame deletion pave the way for domain mapping of the cerebral cavernous malformation 3 protein.

Voss K, Stahl S, Hogan BM, Reinders J, Schleider E, Schulte-Merker S, Felbor U.

Hum Mutat. 2009 Jun;30(6):1003-11. doi: 10.1002/humu.20996.


Structure-function analysis of core STRIPAK Proteins: a signaling complex implicated in Golgi polarization.

Kean MJ, Ceccarelli DF, Goudreault M, Sanches M, Tate S, Larsen B, Gibson LC, Derry WB, Scott IC, Pelletier L, Baillie GS, Sicheri F, Gingras AC.

J Biol Chem. 2011 Jul 15;286(28):25065-75. doi: 10.1074/jbc.M110.214486. Epub 2011 May 11.


CCM3 interacts with CCM2 indicating common pathogenesis for cerebral cavernous malformations.

Voss K, Stahl S, Schleider E, Ullrich S, Nickel J, Mueller TD, Felbor U.

Neurogenetics. 2007 Nov;8(4):249-56. Epub 2007 Jul 27.


CCM3 signaling through sterile 20-like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations.

Zheng X, Xu C, Di Lorenzo A, Kleaveland B, Zou Z, Seiler C, Chen M, Cheng L, Xiao J, He J, Pack MA, Sessa WC, Kahn ML.

J Clin Invest. 2010 Aug;120(8):2795-804. doi: 10.1172/JCI39679. Epub 2010 Jul 1.


Molecular recognition of leucine-aspartate repeat (LD) motifs by the focal adhesion targeting homology domain of cerebral cavernous malformation 3 (CCM3).

Li X, Ji W, Zhang R, Folta-Stogniew E, Min W, Boggon TJ.

J Biol Chem. 2011 Jul 22;286(29):26138-47. doi: 10.1074/jbc.M110.211250. Epub 2011 Jun 1.


Protein phosphatase 2a (PP2A) binds within the oligomerization domain of striatin and regulates the phosphorylation and activation of the mammalian Ste20-Like kinase Mst3.

Gordon J, Hwang J, Carrier KJ, Jones CA, Kern QL, Moreno CS, Karas RH, Pallas DC.

BMC Biochem. 2011 Oct 10;12:54. doi: 10.1186/1471-2091-12-54.


CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation.

Fidalgo M, Fraile M, Pires A, Force T, Pombo C, Zalvide J.

J Cell Sci. 2010 Apr 15;123(Pt 8):1274-84. doi: 10.1242/jcs.061341. Epub 2010 Mar 23.


Adaptor protein cerebral cavernous malformation 3 (CCM3) mediates phosphorylation of the cytoskeletal proteins ezrin/radixin/moesin by mammalian Ste20-4 to protect cells from oxidative stress.

Fidalgo M, Guerrero A, Fraile M, Iglesias C, Pombo CM, Zalvide J.

J Biol Chem. 2012 Mar 30;287(14):11556-65. doi: 10.1074/jbc.M111.320259. Epub 2012 Jan 30.


The CCM3-GCKIII partnership.

Zalvide J, Fidalgo M, Fraile M, Guerrero A, Iglesias C, Floridia E, Pombo CM.

Histol Histopathol. 2013 Oct;28(10):1265-72. doi: 10.14670/HH-28.1265. Epub 2013 Jun 7. Review.


Crystal structure of CCM3, a cerebral cavernous malformation protein critical for vascular integrity.

Li X, Zhang R, Zhang H, He Y, Ji W, Min W, Boggon TJ.

J Biol Chem. 2010 Jul 30;285(31):24099-107. doi: 10.1074/jbc.M110.128470. Epub 2010 May 19.


Structural basis for the unique heterodimeric assembly between cerebral cavernous malformation 3 and germinal center kinase III.

Xu X, Wang X, Zhang Y, Wang DC, Ding J.

Structure. 2013 Jun 4;21(6):1059-66. doi: 10.1016/j.str.2013.04.007. Epub 2013 May 9.


Ccm3 functions in a manner distinct from Ccm1 and Ccm2 in a zebrafish model of CCM vascular disease.

Yoruk B, Gillers BS, Chi NC, Scott IC.

Dev Biol. 2012 Feb 15;362(2):121-31. doi: 10.1016/j.ydbio.2011.12.006. Epub 2011 Dec 11.


SOcK, MiSTs, MASK and STicKs: the GCKIII (germinal centre kinase III) kinases and their heterologous protein-protein interactions.

Sugden PH, McGuffin LJ, Clerk A.

Biochem J. 2013 Aug 15;454(1):13-30. doi: 10.1042/BJ20130219. Review.


PDCD10 interacts with Ste20-related kinase MST4 to promote cell growth and transformation via modulation of the ERK pathway.

Ma X, Zhao H, Shan J, Long F, Chen Y, Chen Y, Zhang Y, Han X, Ma D.

Mol Biol Cell. 2007 Jun;18(6):1965-78. Epub 2007 Mar 14.


Crystal structure of human programmed cell death 10 complexed with inositol-(1,3,4,5)-tetrakisphosphate: a novel adaptor protein involved in human cerebral cavernous malformation.

Ding J, Wang X, Li DF, Hu Y, Zhang Y, Wang DC.

Biochem Biophys Res Commun. 2010 Sep 3;399(4):587-92. doi: 10.1016/j.bbrc.2010.07.119. Epub 2010 Aug 2.


Crystallization and preliminary X-ray crystallographic study of the human MST2 SARAH domain.

Song J, Hong H, Choi S, Lee YH, Yamashita E, Bae SC, Park IY, Lee SJ.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Nov 1;67(Pt 11):1403-5. doi: 10.1107/S1744309111033823. Epub 2011 Oct 27.


Crystallization and preliminary X-ray characterization of Epstein-Barr virus BHRF1 in complex with a benzoylurea peptidomimetic.

Caria S, Chugh S, Nhu D, Lessene G, Kvansakul M.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2012 Dec 1;68(Pt 12):1521-4. doi: 10.1107/S1744309112043333. Epub 2012 Nov 14.

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