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Hepatitis C viral protein NS5A induces EMT and participates in oncogenic transformation of primary hepatocyte precursors.

Akkari L, Grégoire D, Floc'h N, Moreau M, Hernandez C, Simonin Y, Rosenberg AR, Lassus P, Hibner U.

J Hepatol. 2012 Nov;57(5):1021-8. doi: 10.1016/j.jhep.2012.06.027. Epub 2012 Jun 28.


Reply to: "Are Hedgehog and Wnt/β-catenin pathways involved in hepatitis C virus-mediated EMT?": persistent activation of Hedgehog or Wnt/β-catenin pathways is not involved in EMT mediated by HCV NS5A protein.

Grégoire D, Akkari L, Carenco C, Hibner U.

J Hepatol. 2013 Mar;58(3):637-8. doi: 10.1016/j.jhep.2012.11.026. Epub 2012 Nov 28. No abstract available.


Are Hedgehog and Wnt/β-catenin pathways involved in hepatitis C virus-mediated EMT?

Conti B, Minutolo A, Arciello M, Balsano C.

J Hepatol. 2013 Mar;58(3):636-7. doi: 10.1016/j.jhep.2012.10.033. Epub 2012 Nov 27. No abstract available.


TLR4 Signaling via NANOG Cooperates With STAT3 to Activate Twist1 and Promote Formation of Tumor-Initiating Stem-Like Cells in Livers of Mice.

Uthaya Kumar DB, Chen CL, Liu JC, Feldman DE, Sher LS, French S, DiNorcia J, French SW, Naini BV, Junrungsee S, Agopian VG, Zarrinpar A, Machida K.

Gastroenterology. 2016 Mar;150(3):707-19. doi: 10.1053/j.gastro.2015.11.002. Epub 2015 Nov 12.


The oncogenic potential of hepatitis C virus NS5A sequence variants is associated with PKR regulation.

Giménez-Barcons M, Wang C, Chen M, Sánchez-Tapias JM, Sáiz JC, Gale M Jr.

J Interferon Cytokine Res. 2005 Mar;25(3):152-64.


Promotion of Cancer Stem-Like Cell Properties in Hepatitis C Virus-Infected Hepatocytes.

Kwon YC, Bose SK, Steele R, Meyer K, Di Bisceglie AM, Ray RB, Ray R.

J Virol. 2015 Nov;89(22):11549-56. doi: 10.1128/JVI.01946-15. Epub 2015 Sep 9.


ILEI requires oncogenic Ras for the epithelial to mesenchymal transition of hepatocytes and liver carcinoma progression.

Lahsnig C, Mikula M, Petz M, Zulehner G, Schneller D, van Zijl F, Huber H, Csiszar A, Beug H, Mikulits W.

Oncogene. 2009 Feb 5;28(5):638-50. doi: 10.1038/onc.2008.418. Epub 2008 Nov 17.


Small heterodimer partner 1 directly interacts with NS5A viral protein and has a key role in HCV related liver cell transformation.

Conti B, Porcu C, Viscomi C, Minutolo A, Costantini S, Corazzari M, Iannucci G, Barbaro B, Balsano C.

Oncotarget. 2016 Dec 20;7(51):84575-84586. doi: 10.18632/oncotarget.12144.



Friedman SL.

J Hepatol. 2012 Nov;57(5):935-6. doi: 10.1016/j.jhep.2012.08.015. Epub 2012 Aug 23. No abstract available.


Hepatitis C virus NS5A protein enhances gluconeogenesis through upregulation of Akt-/JNK-PEPCK signalling pathways.

Kuo YC, Chen IY, Chang SC, Wu SC, Hung TM, Lee PH, Shimotohno K, Chang MF.

Liver Int. 2014 Oct;34(9):1358-68.


Hepatitis C virus-induced activation of β-catenin promotes c-Myc expression and a cascade of pro-carcinogenetic events.

Higgs MR, Lerat H, Pawlotsky JM.

Oncogene. 2013 Sep 26;32(39):4683-93. doi: 10.1038/onc.2012.484. Epub 2012 Oct 29.


Intracellular expression of the proliferative marker Ki-67 and viral proteins (NS3, NS5A and C) in chronic, long lasting hepatitis C virus (HCV) infection.

Kasprzak A, Adamek A, Biczysko W, Seidel J, Przybyszewska W, Olejniczak K, Juszczyk J, Zabel M.

Folia Histochem Cytobiol. 2007;45(4):357-66.


The hepatitis C virus non-structural NS5A protein inhibits activating protein-1 function by perturbing ras-ERK pathway signaling.

Macdonald A, Crowder K, Street A, McCormick C, Saksela K, Harris M.

J Biol Chem. 2003 May 16;278(20):17775-84. Epub 2003 Mar 5.


Control of temporal activation of hepatitis C virus-induced interferon response by domain 2 of nonstructural protein 5A.

Hiet MS, Bauhofer O, Zayas M, Roth H, Tanaka Y, Schirmacher P, Willemsen J, Grünvogel O, Bender S, Binder M, Lohmann V, Lotteau V, Ruggieri A, Bartenschlager R.

J Hepatol. 2015 Oct;63(4):829-37. doi: 10.1016/j.jhep.2015.04.015. Epub 2015 Apr 20.


Expression of hepatitis C virus non-structural 5A protein in the liver of transgenic mice.

Majumder M, Steele R, Ghosh AK, Zhou XY, Thornburg L, Ray R, Phillips NJ, Ray RB.

FEBS Lett. 2003 Dec 18;555(3):528-32.


The NS5A protein of hepatitis C virus transcriptionally upregulates the AGR3 gene expression.

Chen M, Gan X, Deng L, Hotta H.

Kobe J Med Sci. 2015 Apr 7;61(1):E27-35.


Human lung epithelial cells progressed to malignancy through specific oncogenic manipulations.

Sato M, Larsen JE, Lee W, Sun H, Shames DS, Dalvi MP, Ramirez RD, Tang H, DiMaio JM, Gao B, Xie Y, Wistuba II, Gazdar AF, Shay JW, Minna JD.

Mol Cancer Res. 2013 Jun;11(6):638-50. doi: 10.1158/1541-7786.MCR-12-0634-T. Epub 2013 Feb 28.


Hepatitis C virus induces epithelial-mesenchymal transition in primary human hepatocytes.

Bose SK, Meyer K, Di Bisceglie AM, Ray RB, Ray R.

J Virol. 2012 Dec;86(24):13621-8. doi: 10.1128/JVI.02016-12. Epub 2012 Oct 3.

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