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Items: 1 to 20 of 79

1.

Exploiting synthetic lethal interactions between DNA damage signaling, checkpoint control, and p53 for targeted cancer therapy.

Morandell S, Yaffe MB.

Prog Mol Biol Transl Sci. 2012;110:289-314. doi: 10.1016/B978-0-12-387665-2.00011-0. Review.

PMID:
22749150
2.

Exploiting synthetic lethal interactions for targeted cancer therapy.

Reinhardt HC, Jiang H, Hemann MT, Yaffe MB.

Cell Cycle. 2009 Oct 1;8(19):3112-9. Review.

3.

Targeting the Checkpoint to Kill Cancer Cells.

Benada J, Macurek L.

Biomolecules. 2015 Aug 18;5(3):1912-37. doi: 10.3390/biom5031912. Review.

4.

DNA damage response pathways and cell cycle checkpoints in colorectal cancer: current concepts and future perspectives for targeted treatment.

Solier S, Zhang YW, Ballestrero A, Pommier Y, Zoppoli G.

Curr Cancer Drug Targets. 2012 May;12(4):356-71. Review.

PMID:
22385513
5.

Importance of DNA damage checkpoints in the pathogenesis of human cancers.

Poehlmann A, Roessner A.

Pathol Res Pract. 2010 Sep 15;206(9):591-601. doi: 10.1016/j.prp.2010.06.006. Review.

PMID:
20674189
6.

[Synthetic lethal genes to mutant p53].

Tongyang L, Haiqiang G, Meiyan Z, Yingze H, Shuting J, Ying L, Jihong Z.

Yi Chuan. 2015 Apr;37(4):321-6. doi: 10.16288/j.yczz.14-277. Review. Chinese.

PMID:
25881697
7.

The intersection between DNA damage response and cell death pathways.

Nowsheen S, Yang ES.

Exp Oncol. 2012 Oct;34(3):243-54. Review.

8.

Characterization of the p53 cistrome--DNA binding cooperativity dissects p53's tumor suppressor functions.

Schlereth K, Heyl C, Krampitz AM, Mernberger M, Finkernagel F, Scharfe M, Jarek M, Leich E, Rosenwald A, Stiewe T.

PLoS Genet. 2013;9(8):e1003726. doi: 10.1371/journal.pgen.1003726.

9.

p53 Promotes cell survival due to the reversibility of its cell-cycle checkpoints.

Lukin DJ, Carvajal LA, Liu WJ, Resnick-Silverman L, Manfredi JJ.

Mol Cancer Res. 2015 Jan;13(1):16-28. doi: 10.1158/1541-7786.MCR-14-0177.

10.

Cell cycle checkpoints and their impact on anticancer therapeutic strategies.

Eastman A.

J Cell Biochem. 2004 Feb 1;91(2):223-31. Review.

PMID:
14743382
11.

CDK2 transcriptional repression is an essential effector in p53-dependent cellular senescence-implications for therapeutic intervention.

Zalzali H, Nasr B, Harajly M, Basma H, Ghamloush F, Ghayad S, Ghanem N, Evan GI, Saab R.

Mol Cancer Res. 2015 Jan;13(1):29-40. doi: 10.1158/1541-7786.MCR-14-0163.

12.

The p53 protein and its molecular network: modelling a missing link between DNA damage and cell fate.

Eliaš J, Dimitrio L, Clairambault J, Natalini R.

Biochim Biophys Acta. 2014 Jan;1844(1 Pt B):232-47. doi: 10.1016/j.bbapap.2013.09.019. Review.

PMID:
24113167
13.

DNA repair dysregulation from cancer driver to therapeutic target.

Curtin NJ.

Nat Rev Cancer. 2012 Dec;12(12):801-17. doi: 10.1038/nrc3399. Review.

PMID:
23175119
14.

The role of DNA damage responses in p53 biology.

Speidel D.

Arch Toxicol. 2015 Apr;89(4):501-17. doi: 10.1007/s00204-015-1459-z. Review.

PMID:
25618545
15.

Targeting DNA repair mechanisms in cancer.

Furgason JM, Bahassi el M.

Pharmacol Ther. 2013 Mar;137(3):298-308. doi: 10.1016/j.pharmthera.2012.10.009. Review.

PMID:
23107892
16.

DNA damage response genes and the development of cancer metastasis.

Broustas CG, Lieberman HB.

Radiat Res. 2014 Feb;181(2):111-30. doi: 10.1667/RR13515.1. Review.

17.

New insights into p53 signaling and cancer cell response to DNA damage: implications for cancer therapy.

Mirzayans R, Andrais B, Scott A, Murray D.

J Biomed Biotechnol. 2012;2012:170325. doi: 10.1155/2012/170325. Review.

18.

Sterigmatocystin-induced DNA damage triggers G2 arrest via an ATM/p53-related pathway in human gastric epithelium GES-1 cells in vitro.

Zhang D, Cui Y, Shen H, Xing L, Cui J, Wang J, Zhang X.

PLoS One. 2013 May 21;8(5):e65044. doi: 10.1371/journal.pone.0065044.

19.

Down-regulation of nuclear protein ICBP90 by p53/p21Cip1/WAF1-dependent DNA-damage checkpoint signals contributes to cell cycle arrest at G1/S transition.

Arima Y, Hirota T, Bronner C, Mousli M, Fujiwara T, Niwa S, Ishikawa H, Saya H.

Genes Cells. 2004 Feb;9(2):131-42.

20.

Poly(ADP-ribose) polymerase inhibition enhances p53-dependent and -independent DNA damage responses induced by DNA damaging agent.

Nguyen D, Zajac-Kaye M, Rubinstein L, Voeller D, Tomaszewski JE, Kummar S, Chen AP, Pommier Y, Doroshow JH, Yang SX.

Cell Cycle. 2011 Dec 1;10(23):4074-82. doi: 10.4161/cc.10.23.18170.

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