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Items: 1 to 20 of 95


Extracellularly delivered single-stranded viral RNA causes neurodegeneration dependent on TLR7.

Lehmann SM, Rosenberger K, Krüger C, Habbel P, Derkow K, Kaul D, Rybak A, Brandt C, Schott E, Wulczyn FG, Lehnardt S.

J Immunol. 2012 Aug 1;189(3):1448-58. doi: 10.4049/jimmunol.1201078. Epub 2012 Jun 27.


TLR7 negatively regulates dendrite outgrowth through the Myd88-c-Fos-IL-6 pathway.

Liu HY, Hong YF, Huang CM, Chen CY, Huang TN, Hsueh YP.

J Neurosci. 2013 Jul 10;33(28):11479-93. doi: 10.1523/JNEUROSCI.5566-12.2013.


A mechanism for neurodegeneration induced by group B streptococci through activation of the TLR2/MyD88 pathway in microglia.

Lehnardt S, Henneke P, Lien E, Kasper DL, Volpe JJ, Bechmann I, Nitsch R, Weber JR, Golenbock DT, Vartanian T.

J Immunol. 2006 Jul 1;177(1):583-92.


A point mutation in the amino terminus of TLR7 abolishes signaling without affecting ligand binding.

Iavarone C, Ramsauer K, Kubarenko AV, Debasitis JC, Leykin I, Weber AN, Siggs OM, Beutler B, Zhang P, Otten G, D'Oro U, Valiante NM, Mbow ML, Visintin A.

J Immunol. 2011 Apr 1;186(7):4213-22. doi: 10.4049/jimmunol.1003585. Epub 2011 Mar 7.


Toll-like receptor 7 cooperates with IL-4 in activated B cells through antigen receptor or CD38 and induces class switch recombination and IgG1 production.

Tsukamoto Y, Nagai Y, Kariyone A, Shibata T, Kaisho T, Akira S, Miyake K, Takatsu K.

Mol Immunol. 2009 Apr;46(7):1278-88. doi: 10.1016/j.molimm.2008.11.022. Epub 2009 Jan 20.


Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA.

Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C.

Science. 2004 Mar 5;303(5663):1529-31. Epub 2004 Feb 19.


Flavivirus activation of plasmacytoid dendritic cells delineates key elements of TLR7 signaling beyond endosomal recognition.

Wang JP, Liu P, Latz E, Golenbock DT, Finberg RW, Libraty DH.

J Immunol. 2006 Nov 15;177(10):7114-21.


Cutting Edge: Antibody-mediated TLR7-dependent recognition of viral RNA.

Wang JP, Asher DR, Chan M, Kurt-Jones EA, Finberg RW.

J Immunol. 2007 Mar 15;178(6):3363-7.


Triggering TLR7 in mice induces immune activation and lymphoid system disruption, resembling HIV-mediated pathology.

Baenziger S, Heikenwalder M, Johansen P, Schlaepfer E, Hofer U, Miller RC, Diemand S, Honda K, Kundig TM, Aguzzi A, Speck RF.

Blood. 2009 Jan 8;113(2):377-88. doi: 10.1182/blood-2008-04-151712. Epub 2008 Sep 29.


RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement.

Lau CM, Broughton C, Tabor AS, Akira S, Flavell RA, Mamula MJ, Christensen SR, Shlomchik MJ, Viglianti GA, Rifkin IR, Marshak-Rothstein A.

J Exp Med. 2005 Nov 7;202(9):1171-7. Epub 2005 Oct 31.


Heat-killed Brucella abortus induces TNF and IL-12p40 by distinct MyD88-dependent pathways: TNF, unlike IL-12p40 secretion, is Toll-like receptor 2 dependent.

Huang LY, Aliberti J, Leifer CA, Segal DM, Sher A, Golenbock DT, Golding B.

J Immunol. 2003 Aug 1;171(3):1441-6.


The impact of single and pairwise Toll-like receptor activation on neuroinflammation and neurodegeneration.

Rosenberger K, Derkow K, Dembny P, Krüger C, Schott E, Lehnardt S.

J Neuroinflammation. 2014 Sep 20;11:166. doi: 10.1186/s12974-014-0166-7.


Contribution of TLR7 and TLR9 signaling to the susceptibility of MyD88-deficient mice to myocarditis.

Pagni PP, Traub S, Demaria O, Chasson L, Alexopoulou L.

Autoimmunity. 2010 Jun;43(4):275-87. doi: 10.3109/08916930903509056.


Cardiac RNA induces inflammatory responses in cardiomyocytes and immune cells via Toll-like receptor 7 signaling.

Feng Y, Chen H, Cai J, Zou L, Yan D, Xu G, Li D, Chao W.

J Biol Chem. 2015 Oct 30;290(44):26688-98. doi: 10.1074/jbc.M115.661835. Epub 2015 Sep 11.


The microRNAs Let7c and miR21 are recognized by neuronal Toll-like receptor 7 to restrict dendritic growth of neurons.

Liu HY, Huang CM, Hung YF, Hsueh YP.

Exp Neurol. 2015 Jul;269:202-12. doi: 10.1016/j.expneurol.2015.04.011. Epub 2015 Apr 24.


Intrathecal heat shock protein 60 mediates neurodegeneration and demyelination in the CNS through a TLR4- and MyD88-dependent pathway.

Rosenberger K, Dembny P, Derkow K, Engel O, Krüger C, Wolf SA, Kettenmann H, Schott E, Meisel A, Lehnardt S.

Mol Neurodegener. 2015 Feb 26;10:5. doi: 10.1186/s13024-015-0003-1.


Conventional dendritic cells mount a type I IFN response against Candida spp. requiring novel phagosomal TLR7-mediated IFN-β signaling.

Bourgeois C, Majer O, Frohner IE, Lesiak-Markowicz I, Hildering KS, Glaser W, Stockinger S, Decker T, Akira S, Müller M, Kuchler K.

J Immunol. 2011 Mar 1;186(5):3104-12. doi: 10.4049/jimmunol.1002599. Epub 2011 Jan 31.


Antitumor activity and immune response induction of a dual agonist of Toll-like receptors 7 and 8.

Wang D, Precopio M, Lan T, Yu D, Tang JX, Kandimalla ER, Agrawal S.

Mol Cancer Ther. 2010 Jun;9(6):1788-97. doi: 10.1158/1535-7163.MCT-09-1198. Epub 2010 Jun 1.


Nucleic acid agonists for Toll-like receptor 7 are defined by the presence of uridine ribonucleotides.

Diebold SS, Massacrier C, Akira S, Paturel C, Morel Y, Reis e Sousa C.

Eur J Immunol. 2006 Dec;36(12):3256-67.

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