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Items: 1 to 20 of 109

1.

Identification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assays.

Mukherjee S, Hanson AM, Shadrick WR, Ndjomou J, Sweeney NL, Hernandez JJ, Bartczak D, Li K, Frankowski KJ, Heck JA, Arnold LA, Schoenen FJ, Frick DN.

Nucleic Acids Res. 2012 Sep 1;40(17):8607-21. Epub 2012 Jun 27.

2.

Fluorescent primuline derivatives inhibit hepatitis C virus NS3-catalyzed RNA unwinding, peptide hydrolysis and viral replicase formation.

Ndjomou J, Kolli R, Mukherjee S, Shadrick WR, Hanson AM, Sweeney NL, Bartczak D, Li K, Frankowski KJ, Schoenen FJ, Frick DN.

Antiviral Res. 2012 Nov;96(2):245-55. doi: 10.1016/j.antiviral.2012.08.006. Epub 2012 Aug 25.

3.

Optimization of potent hepatitis C virus NS3 helicase inhibitors isolated from the yellow dyes thioflavine S and primuline.

Li K, Frankowski KJ, Belon CA, Neuenswander B, Ndjomou J, Hanson AM, Shanahan MA, Schoenen FJ, Blagg BS, Aubé J, Frick DN.

J Med Chem. 2012 Apr 12;55(7):3319-30. doi: 10.1021/jm300021v. Epub 2012 Mar 22.

4.
5.

Identification of a resveratrol tetramer as a potent inhibitor of hepatitis C virus helicase.

Lee S, Yoon KD, Lee M, Cho Y, Choi G, Jang H, Kim B, Jung DH, Oh JG, Kim GW, Oh JW, Jeong YJ, Kwon HJ, Bae SK, Min DH, Windisch MP, Heo TH, Lee C.

Br J Pharmacol. 2016 Jan;173(1):191-211. doi: 10.1111/bph.13358. Epub 2015 Nov 25.

6.

Mechanism and specificity of a symmetrical benzimidazolephenylcarboxamide helicase inhibitor.

Belon CA, High YD, Lin TI, Pauwels F, Frick DN.

Biochemistry. 2010 Mar 9;49(9):1822-32. doi: 10.1021/bi901974a.

7.

Identification of Hydroxyanthraquinones as Novel Inhibitors of Hepatitis C Virus NS3 Helicase.

Furuta A, Tsubuki M, Endoh M, Miyamoto T, Tanaka J, Salam KA, Akimitsu N, Tani H, Yamashita A, Moriishi K, Nakakoshi M, Sekiguchi Y, Tsuneda S, Noda N.

Int J Mol Sci. 2015 Aug 7;16(8):18439-53. doi: 10.3390/ijms160818439.

8.

Identification and analysis of inhibitors targeting the hepatitis C virus NS3 helicase.

Hanson AM, Hernandez JJ, Shadrick WR, Frick DN.

Methods Enzymol. 2012;511:463-83. doi: 10.1016/B978-0-12-396546-2.00021-8.

9.

Primuline derivatives that mimic RNA to stimulate hepatitis C virus NS3 helicase-catalyzed ATP hydrolysis.

Sweeney NL, Shadrick WR, Mukherjee S, Li K, Frankowski KJ, Schoenen FJ, Frick DN.

J Biol Chem. 2013 Jul 5;288(27):19949-57. doi: 10.1074/jbc.M113.463166. Epub 2013 May 23.

10.

Real-time monitoring of RNA helicase activity using fluorescence resonance energy transfer in vitro.

Tani H, Fujita O, Furuta A, Matsuda Y, Miyata R, Akimitsu N, Tanaka J, Tsuneda S, Sekiguchi Y, Noda N.

Biochem Biophys Res Commun. 2010 Feb 26;393(1):131-6. doi: 10.1016/j.bbrc.2010.01.100. Epub 2010 Feb 1.

PMID:
20117090
11.

In vitro selection of RNA aptamers against the HCV NS3 helicase domain.

Nishikawa F, Funaji K, Fukuda K, Nishikawa S.

Oligonucleotides. 2004;14(2):114-29.

PMID:
15294075
12.

The helicase activity associated with hepatitis C virus nonstructural protein 3 (NS3).

Tai CL, Chi WK, Chen DS, Hwang LH.

J Virol. 1996 Dec;70(12):8477-84.

13.

Specific targeting of hepatitis C virus NS3 RNA helicase. Discovery of the potent and selective competitive nucleotide-mimicking inhibitor QU663.

Maga G, Gemma S, Fattorusso C, Locatelli GA, Butini S, Persico M, Kukreja G, Romano MP, Chiasserini L, Savini L, Novellino E, Nacci V, Spadari S, Campiani G.

Biochemistry. 2005 Jul 19;44(28):9637-44.

PMID:
16008349
14.

Structure and function of hepatitis C virus NS3 helicase.

Kwong AD, Kim JL, Lin C.

Curr Top Microbiol Immunol. 2000;242:171-96. Review.

PMID:
10592661
15.
16.

Aurintricarboxylic acid modulates the affinity of hepatitis C virus NS3 helicase for both nucleic acid and ATP.

Shadrick WR, Mukherjee S, Hanson AM, Sweeney NL, Frick DN.

Biochemistry. 2013 Sep 10;52(36):6151-9. doi: 10.1021/bi4006495. Epub 2013 Aug 26.

17.

Ebselen inhibits hepatitis C virus NS3 helicase binding to nucleic acid and prevents viral replication.

Mukherjee S, Weiner WS, Schroeder CE, Simpson DS, Hanson AM, Sweeney NL, Marvin RK, Ndjomou J, Kolli R, Isailovic D, Schoenen FJ, Frick DN.

ACS Chem Biol. 2014 Oct 17;9(10):2393-403. doi: 10.1021/cb500512z. Epub 2014 Aug 15.

18.

Designing and analysis of a potent bi-functional aptamers that inhibit protease and helicase activities of HCV NS3.

Umehara T, Fukuda K, Nishikawa F, Sekiya S, Kohara M, Hasegawa T, Nishikawa S.

Nucleic Acids Symp Ser (Oxf). 2004;(48):195-6.

PMID:
17150545
19.

Benzothiazole and Pyrrolone Flavivirus Inhibitors Targeting the Viral Helicase.

Sweeney NL, Hanson AM, Mukherjee S, Ndjomou J, Geiss BJ, Steel JJ, Frankowski KJ, Li K, Schoenen FJ, Frick DN.

ACS Infect Dis. 2015 Mar 13;1(3):140-148.

20.

A fluorescence-based screening assay for identification of hepatitis C virus NS3 helicase inhibitors and characterization of their inhibitory mechanism.

Furuta A, Salam KA, Tani H, Tsuneda S, Sekiguchi Y, Akimitsu N, Noda N.

Methods Mol Biol. 2015;1259:211-28. doi: 10.1007/978-1-4939-2214-7_14.

PMID:
25579589

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