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Soy protein isoflavones differentially regulate liver X receptor isoforms to modulate lipid metabolism and cholesterol transport in the liver and intestine in mice.

González-Granillo M, Steffensen KR, Granados O, Torres N, Korach-André M, Ortíz V, Aguilar-Salinas C, Jakobsson T, Díaz-Villaseñor A, Loza-Valdes A, Hernandez-Pando R, Gustafsson JÅ, Tovar AR.

Diabetologia. 2012 Sep;55(9):2469-78. doi: 10.1007/s00125-012-2599-9.


LXRβ activation increases intestinal cholesterol absorption, leading to an atherogenic lipoprotein profile.

Hu X, Steffensen KR, Jiang ZY, Parini P, Gustafsson JÅ, Gåfvels M, Eggertsen G.

J Intern Med. 2012 Nov;272(5):452-64. doi: 10.1111/j.1365-2796.2012.02529.x.


Liver X receptor (LXR)-beta regulation in LXRalpha-deficient mice: implications for therapeutic targeting.

Quinet EM, Savio DA, Halpern AR, Chen L, Schuster GU, Gustafsson JA, Basso MD, Nambi P.

Mol Pharmacol. 2006 Oct;70(4):1340-9.


Dietary soy protein isolate attenuates metabolic syndrome in rats via effects on PPAR, LXR, and SREBP signaling.

Ronis MJ, Chen Y, Badeaux J, Badger TM.

J Nutr. 2009 Aug;139(8):1431-8. doi: 10.3945/jn.109.107029.


Different roles of liver X receptor alpha and beta in lipid metabolism: effects of an alpha-selective and a dual agonist in mice deficient in each subtype.

Lund EG, Peterson LB, Adams AD, Lam MH, Burton CA, Chin J, Guo Q, Huang S, Latham M, Lopez JC, Menke JG, Milot DP, Mitnaul LJ, Rex-Rabe SE, Rosa RL, Tian JY, Wright SD, Sparrow CP.

Biochem Pharmacol. 2006 Feb 14;71(4):453-63.


Retinoic acid receptor-related orphan receptor α-induced activation of adenosine monophosphate-activated protein kinase results in attenuation of hepatic steatosis.

Kim EJ, Yoon YS, Hong S, Son HY, Na TY, Lee MH, Kang HJ, Park J, Cho WJ, Kim SG, Koo SH, Park HG, Lee MO.

Hepatology. 2012 May;55(5):1379-88. doi: 10.1002/hep.25529. Erratum in: Hepatology. 2013 Jan;57(1):423.


Liver LXRα expression is crucial for whole body cholesterol homeostasis and reverse cholesterol transport in mice.

Zhang Y, Breevoort SR, Angdisen J, Fu M, Schmidt DR, Holmstrom SR, Kliewer SA, Mangelsdorf DJ, Schulman IG.

J Clin Invest. 2012 May;122(5):1688-99. doi: 10.1172/JCI59817.


Separate and overlapping metabolic functions of LXRalpha and LXRbeta in C57Bl/6 female mice.

Korach-André M, Parini P, Larsson L, Arner A, Steffensen KR, Gustafsson JA.

Am J Physiol Endocrinol Metab. 2010 Feb;298(2):E167-78. doi: 10.1152/ajpendo.00184.2009.


Pharmacological LXR activation reduces presence of SR-B1 in liver membranes contributing to LXR-mediated induction of HDL-cholesterol.

Grefhorst A, Oosterveer MH, Brufau G, Boesjes M, Kuipers F, Groen AK.

Atherosclerosis. 2012 Jun;222(2):382-9. doi: 10.1016/j.atherosclerosis.2012.02.014.


LXR driven induction of HDL-cholesterol is independent of intestinal cholesterol absorption and ABCA1 protein expression.

Kannisto K, Gåfvels M, Jiang ZY, Slätis K, Hu X, Jorns C, Steffensen KR, Eggertsen G.

Lipids. 2014 Jan;49(1):71-83. doi: 10.1007/s11745-013-3853-8.


miR-206 controls LXRα expression and promotes LXR-mediated cholesterol efflux in macrophages.

Vinod M, Chennamsetty I, Colin S, Belloy L, De Paoli F, Schaider H, Graier WF, Frank S, Kratky D, Staels B, Chinetti-Gbaguidi G, Kostner GM.

Biochim Biophys Acta. 2014 Jun;1841(6):827-35. doi: 10.1016/j.bbalip.2014.02.006.


Liver X receptor in cholesterol metabolism.

Zhao C, Dahlman-Wright K.

J Endocrinol. 2010 Mar;204(3):233-40. doi: 10.1677/JOE-09-0271. Review.


The Niemann-Pick C1 like 1 (NPC1L1) inhibitor ezetimibe improves metabolic disease via decreased liver X receptor (LXR) activity in liver of obese male mice.

Sugizaki T, Watanabe M, Horai Y, Kaneko-Iwasaki N, Arita E, Miyazaki T, Morimoto K, Honda A, Irie J, Itoh H.

Endocrinology. 2014 Aug;155(8):2810-9. doi: 10.1210/en.2013-2143.


Cholesterol feeding strongly reduces hepatic VLDL-triglyceride production in mice lacking the liver X receptor alpha.

van der Veen JN, Havinga R, Bloks VW, Groen AK, Kuipers F.

J Lipid Res. 2007 Feb;48(2):337-47.


Induction of intestinal ATP-binding cassette transporters by a phytosterol-derived liver X receptor agonist.

Kaneko E, Matsuda M, Yamada Y, Tachibana Y, Shimomura I, Makishima M.

J Biol Chem. 2003 Sep 19;278(38):36091-8.


The role of liver X receptor-alpha in the fatty acid regulation of hepatic gene expression.

Pawar A, Botolin D, Mangelsdorf DJ, Jump DB.

J Biol Chem. 2003 Oct 17;278(42):40736-43.


Resveratrol inhibits LXRα-dependent hepatic lipogenesis through novel antioxidant Sestrin2 gene induction.

Jin SH, Yang JH, Shin BY, Seo K, Shin SM, Cho IJ, Ki SH.

Toxicol Appl Pharmacol. 2013 Aug 15;271(1):95-105. doi: 10.1016/j.taap.2013.04.023.


Soya protein stimulates bile acid excretion by the liver and intestine through direct and indirect pathways influenced by the presence of dietary cholesterol.

Arellano-Martínez GL, Granados O, Palacios-González B, Torres N, Medina-Vera I, Tovar AR.

Br J Nutr. 2014 Jun 28;111(12):2059-66. doi: 10.1017/S0007114514000361.


Liver X receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesis.

Tobin KA, Ulven SM, Schuster GU, Steineger HH, Andresen SM, Gustafsson JA, Nebb HI.

J Biol Chem. 2002 Mar 22;277(12):10691-7.


Pharmacological activation of LXR in utero directly influences ABC transporter expression and function in mice but does not affect adult cholesterol metabolism.

van Straten EM, Huijkman NC, Baller JF, Kuipers F, Plösch T.

Am J Physiol Endocrinol Metab. 2008 Dec;295(6):E1341-8. doi: 10.1152/ajpendo.90597.2008.

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