Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 122

1.

Simulation of the opening and closing of Hsp70 chaperones by coarse-grained molecular dynamics.

Gołaś E, Maisuradze GG, Senet P, Ołdziej S, Czaplewski C, Scheraga HA, Liwo A.

J Chem Theory Comput. 2012 May 8;8(5):1750-1764. Epub 2012 Mar 15.

2.

Human Inducible Hsp70: Structures, Dynamics, and Interdomain Communication from All-Atom Molecular Dynamics Simulations.

Nicolaï A, Senet P, Delarue P, Ripoll DR.

J Chem Theory Comput. 2010 Aug 10;6(8):2501-19. doi: 10.1021/ct1002169.

PMID:
26613502
3.

Structure and dynamics of the ATP-bound open conformation of Hsp70 chaperones.

Kityk R, Kopp J, Sinning I, Mayer MP.

Mol Cell. 2012 Dec 28;48(6):863-74. doi: 10.1016/j.molcel.2012.09.023. Epub 2012 Nov 1.

4.

Insights into the molecular mechanism of allostery in Hsp70s.

Mayer MP, Kityk R.

Front Mol Biosci. 2015 Oct 20;2:58. doi: 10.3389/fmolb.2015.00058. eCollection 2015. Review.

5.

The Hsp70 interdomain linker is a dynamic switch that enables allosteric communication between two structured domains.

English CA, Sherman W, Meng W, Gierasch LM.

J Biol Chem. 2017 Sep 8;292(36):14765-14774. doi: 10.1074/jbc.M117.789313. Epub 2017 Jul 28.

PMID:
28754691
6.

Allostery in Hsp70 chaperones is transduced by subdomain rotations.

Bhattacharya A, Kurochkin AV, Yip GN, Zhang Y, Bertelsen EB, Zuiderweg ER.

J Mol Biol. 2009 May 8;388(3):475-90. doi: 10.1016/j.jmb.2009.01.062. Epub 2009 Feb 4.

7.

Common functionally important motions of the nucleotide-binding domain of Hsp70.

Gołaś EI, Czaplewski C, Scheraga HA, Liwo A.

Proteins. 2015 Feb;83(2):282-99. doi: 10.1002/prot.24731. Epub 2014 Dec 18.

8.

An atomistic view of Hsp70 allosteric crosstalk: from the nucleotide to the substrate binding domain and back.

Chiappori F, Merelli I, Milanesi L, Colombo G, Morra G.

Sci Rep. 2016 Mar 30;6:23474. doi: 10.1038/srep23474.

9.

ATP-induced conformational changes in Hsp70: molecular dynamics and experimental validation of an in silico predicted conformation.

Woo HJ, Jiang J, Lafer EM, Sousa R.

Biochemistry. 2009 Dec 8;48(48):11470-7. doi: 10.1021/bi901256y.

10.

Direct inter-subdomain interactions switch between the closed and open forms of the Hsp70 nucleotide-binding domain in the nucleotide-free state.

Shida M, Arakawa A, Ishii R, Kishishita S, Takagi T, Kukimoto-Niino M, Sugano S, Tanaka A, Shirouzu M, Yokoyama S.

Acta Crystallogr D Biol Crystallogr. 2010 Mar;66(Pt 3):223-32. doi: 10.1107/S0907444909053979. Epub 2010 Feb 12.

PMID:
20179333
11.

An interdomain energetic tug-of-war creates the allosterically active state in Hsp70 molecular chaperones.

Zhuravleva A, Clerico EM, Gierasch LM.

Cell. 2012 Dec 7;151(6):1296-307. doi: 10.1016/j.cell.2012.11.002.

12.

Substrate-binding domain conformational dynamics mediate Hsp70 allostery.

Zhuravleva A, Gierasch LM.

Proc Natl Acad Sci U S A. 2015 Jun 2;112(22):E2865-73. doi: 10.1073/pnas.1506692112. Epub 2015 May 18.

13.

Amide hydrogen exchange reveals conformational changes in hsp70 chaperones important for allosteric regulation.

Rist W, Graf C, Bukau B, Mayer MP.

J Biol Chem. 2006 Jun 16;281(24):16493-501. Epub 2006 Apr 13.

14.

Crystal structure of the stress-inducible human heat shock protein 70 substrate-binding domain in complex with peptide substrate.

Zhang P, Leu JI, Murphy ME, George DL, Marmorstein R.

PLoS One. 2014 Jul 24;9(7):e103518. doi: 10.1371/journal.pone.0103518. eCollection 2014.

15.

Molecular mechanism of allosteric communication in Hsp70 revealed by molecular dynamics simulations.

Chiappori F, Merelli I, Colombo G, Milanesi L, Morra G.

PLoS Comput Biol. 2012;8(12):e1002844. doi: 10.1371/journal.pcbi.1002844. Epub 2012 Dec 27.

16.

Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP.

Qi R, Sarbeng EB, Liu Q, Le KQ, Xu X, Xu H, Yang J, Wong JL, Vorvis C, Hendrickson WA, Zhou L, Liu Q.

Nat Struct Mol Biol. 2013 Jul;20(7):900-7. doi: 10.1038/nsmb.2583. Epub 2013 May 26.

17.

Molecular Mechanism of J-Domain-Triggered ATP Hydrolysis by Hsp70 Chaperones.

Kityk R, Kopp J, Mayer MP.

Mol Cell. 2017 Dec 27. pii: S1097-2765(17)30931-0. doi: 10.1016/j.molcel.2017.12.003. [Epub ahead of print]

PMID:
29290615
18.

Decipher the mechanisms of protein conformational changes induced by nucleotide binding through free-energy landscape analysis: ATP binding to Hsp70.

Nicolaï A, Delarue P, Senet P.

PLoS Comput Biol. 2013;9(12):e1003379. doi: 10.1371/journal.pcbi.1003379. Epub 2013 Dec 12.

19.

Tracking the interplay between bound peptide and the lid domain of DnaK, using molecular dynamics.

Azoulay I, Kucherenko N, Nachliel E, Gutman M, Azem A, Tsfadia Y.

Int J Mol Sci. 2013 Jun 17;14(6):12675-95. doi: 10.3390/ijms140612675.

20.

Conformational dynamics of full-length inducible human Hsp70 derived from microsecond molecular dynamics simulations in explicit solvent.

Nicolaï A, Delarue P, Senet P.

J Biomol Struct Dyn. 2013 Oct;31(10):1111-26. doi: 10.1080/07391102.2012.726190. Epub 2012 Oct 17.

PMID:
23075261

Supplemental Content

Support Center