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p21 promotes error-free replication-coupled DNA double-strand break repair.

Mauro M, Rego MA, Boisvert RA, Esashi F, Cavallo F, Jasin M, Howlett NG.

Nucleic Acids Res. 2012 Sep 1;40(17):8348-60. Epub 2012 Jun 26.


Progression of chromosomal damage induced by etoposide in G2 phase in a DNA-PKcs-deficient context.

Palmitelli M, de Campos-Nebel M, González-Cid M.

Chromosome Res. 2015 Dec;23(4):719-32. doi: 10.1007/s10577-015-9478-4. Epub 2015 Jul 8.


Homologous recombination protects mammalian cells from replication-associated DNA double-strand breaks arising in response to methyl methanesulfonate.

Nikolova T, Ensminger M, Löbrich M, Kaina B.

DNA Repair (Amst). 2010 Oct 5;9(10):1050-63. doi: 10.1016/j.dnarep.2010.07.005. Epub 2010 Aug 13.


p21CDKN1A allows the repair of replication-mediated DNA double-strand breaks induced by topoisomerase I and is inactivated by the checkpoint kinase inhibitor 7-hydroxystaurosporine.

Furuta T, Hayward RL, Meng LH, Takemura H, Aune GJ, Bonner WM, Aladjem MI, Kohn KW, Pommier Y.

Oncogene. 2006 May 11;25(20):2839-49.


Coordination and processing of DNA ends during double-strand break repair: the role of the bacteriophage T4 Mre11/Rad50 (MR) complex.

Almond JR, Stohr BA, Panigrahi AK, Albrecht DW, Nelson SW, Kreuzer KN.

Genetics. 2013 Nov;195(3):739-55. doi: 10.1534/genetics.113.154872. Epub 2013 Aug 26.


Deletion of BRCA2 exon 27 causes defects in response to both stalled and collapsed replication forks.

Kim TM, Son MY, Dodds S, Hu L, Hasty P.

Mutat Res. 2014 Aug-Sep;766-767:66-72. doi: 10.1016/j.mrfmmm.2014.06.003. Epub 2014 Jun 22.


Deletion of BRCA2 exon 27 causes defects in response to both stalled and collapsed replication forks.

Kim TM, Son MY, Dodds S, Hu L, Hasty P.

Mutat Res. 2014 Aug-Sep;766-767:66-72. doi: 10.1016/j.mrfmmm.2014.06.003. Epub 2014 Jun 22.


Non-homologous end joining is the responsible pathway for the repair of fludarabine-induced DNA double strand breaks in mammalian cells.

de Campos-Nebel M, Larripa I, González-Cid M.

Mutat Res. 2008 Nov 10;646(1-2):8-16. doi: 10.1016/j.mrfmmm.2008.08.013. Epub 2008 Sep 4.


DNA double-strand break repair pathway choice is directed by distinct MRE11 nuclease activities.

Shibata A, Moiani D, Arvai AS, Perry J, Harding SM, Genois MM, Maity R, van Rossum-Fikkert S, Kertokalio A, Romoli F, Ismail A, Ismalaj E, Petricci E, Neale MJ, Bristow RG, Masson JY, Wyman C, Jeggo PA, Tainer JA.

Mol Cell. 2014 Jan 9;53(1):7-18. doi: 10.1016/j.molcel.2013.11.003. Epub 2013 Dec 5. Erratum in: Mol Cell. 2014 Jan 23;53(2):361.


Canonical non-homologous end joining in mitosis induces genome instability and is suppressed by M-phase-specific phosphorylation of XRCC4.

Terasawa M, Shinohara A, Shinohara M.

PLoS Genet. 2014 Aug 28;10(8):e1004563. doi: 10.1371/journal.pgen.1004563. eCollection 2014 Aug 28.


Topoisomerase II-mediated DNA damage is differently repaired during the cell cycle by non-homologous end joining and homologous recombination.

de Campos-Nebel M, Larripa I, González-Cid M.

PLoS One. 2010 Sep 2;5(9). pii: e12541. doi: 10.1371/journal.pone.0012541.


Cyclin-dependent kinase-dependent phosphorylation of Lif1 and Sae2 controls imprecise nonhomologous end joining accompanied by double-strand break resection.

Matsuzaki K, Terasawa M, Iwasaki D, Higashide M, Shinohara M.

Genes Cells. 2012 Jun;17(6):473-93. doi: 10.1111/j.1365-2443.2012.01602.x. Epub 2012 May 8.


Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.

Furuta T, Takemura H, Liao ZY, Aune GJ, Redon C, Sedelnikova OA, Pilch DR, Rogakou EP, Celeste A, Chen HT, Nussenzweig A, Aladjem MI, Bonner WM, Pommier Y.

J Biol Chem. 2003 May 30;278(22):20303-12. Epub 2003 Mar 25.


Fanconi anemia group J helicase and MRE11 nuclease interact to facilitate the DNA damage response.

Suhasini AN, Sommers JA, Muniandy PA, Coulombe Y, Cantor SB, Masson JY, Seidman MM, Brosh RM Jr.

Mol Cell Biol. 2013 Jun;33(11):2212-27. doi: 10.1128/MCB.01256-12. Epub 2013 Mar 25.


The complexity of DNA double strand breaks is a critical factor enhancing end-resection.

Yajima H, Fujisawa H, Nakajima NI, Hirakawa H, Jeggo PA, Okayasu R, Fujimori A.

DNA Repair (Amst). 2013 Nov;12(11):936-46. doi: 10.1016/j.dnarep.2013.08.009. Epub 2013 Sep 13.


DNA-PKcs-dependent NHEJ pathway supports the progression of topoisomerase II poison-induced chromosome aberrant cells.

Elguero ME, de Campos-Nebel M, González-Cid M.

Environ Mol Mutagen. 2012 Oct;53(8):608-18. doi: 10.1002/em.21729. Epub 2012 Sep 18.


Phosphorylation of Exo1 modulates homologous recombination repair of DNA double-strand breaks.

Bolderson E, Tomimatsu N, Richard DJ, Boucher D, Kumar R, Pandita TK, Burma S, Khanna KK.

Nucleic Acids Res. 2010 Apr;38(6):1821-31. doi: 10.1093/nar/gkp1164. Epub 2009 Dec 17.


BRCA2 is needed for both repair and cell cycle arrest in mammalian cells exposed to S23906, an anticancer monofunctional DNA binder.

Rocca CJ, Soares DG, Bouzid H, Henriques JA, Larsen AK, Escargueil AE.

Cell Cycle. 2015;14(13):2080-90. doi: 10.1080/15384101.2015.1042632.


Nucleolin mediates nucleosome disruption critical for DNA double-strand break repair.

Goldstein M, Derheimer FA, Tait-Mulder J, Kastan MB.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16874-9. doi: 10.1073/pnas.1306160110. Epub 2013 Sep 30.

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