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Metabolic actions of fibroblast growth factor 21.

Cuevas-Ramos D, Aguilar-Salinas CA, Gómez-Pérez FJ.

Curr Opin Pediatr. 2012 Aug;24(4):523-9. doi: 10.1097/MOP.0b013e3283557d22. Review.


Endocrine regulation of the fasting response by PPARalpha-mediated induction of fibroblast growth factor 21.

Inagaki T, Dutchak P, Zhao G, Ding X, Gautron L, Parameswara V, Li Y, Goetz R, Mohammadi M, Esser V, Elmquist JK, Gerard RD, Burgess SC, Hammer RE, Mangelsdorf DJ, Kliewer SA.

Cell Metab. 2007 Jun;5(6):415-25.


Fibroblast growth factor 21 as an emerging metabolic regulator: clinical perspectives.

Woo YC, Xu A, Wang Y, Lam KS.

Clin Endocrinol (Oxf). 2013 Apr;78(4):489-96. doi: 10.1111/cen.12095. Review.


PPARalpha is a key regulator of hepatic FGF21.

Lundåsen T, Hunt MC, Nilsson LM, Sanyal S, Angelin B, Alexson SE, Rudling M.

Biochem Biophys Res Commun. 2007 Aug 24;360(2):437-40. Epub 2007 Jun 21.


Adipose fibroblast growth factor 21 is up-regulated by peroxisome proliferator-activated receptor gamma and altered metabolic states.

Muise ES, Azzolina B, Kuo DW, El-Sherbeini M, Tan Y, Yuan X, Mu J, Thompson JR, Berger JP, Wong KK.

Mol Pharmacol. 2008 Aug;74(2):403-12. doi: 10.1124/mol.108.044826. Epub 2008 May 8.


Fibroblast growth factor 21 regulates energy metabolism by activating the AMPK-SIRT1-PGC-1alpha pathway.

Chau MD, Gao J, Yang Q, Wu Z, Gromada J.

Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12553-8. doi: 10.1073/pnas.1006962107. Epub 2010 Jun 28.


Fibroblast growth factor 21: from pharmacology to physiology.

Kliewer SA, Mangelsdorf DJ.

Am J Clin Nutr. 2010 Jan;91(1):254S-257S. doi: 10.3945/ajcn.2009.28449B. Epub 2009 Nov 11. Review.


Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin-resistant mouse models--association with liver and adipose tissue effects.

Xu J, Stanislaus S, Chinookoswong N, Lau YY, Hager T, Patel J, Ge H, Weiszmann J, Lu SC, Graham M, Busby J, Hecht R, Li YS, Li Y, Lindberg R, Véniant MM.

Am J Physiol Endocrinol Metab. 2009 Nov;297(5):E1105-14. doi: 10.1152/ajpendo.00348.2009. Epub 2009 Aug 25.


Fibroblast growth factor 21 is a metabolic regulator that plays a role in the adaptation to ketosis.

Domouzoglou EM, Maratos-Flier E.

Am J Clin Nutr. 2011 Apr;93(4):901S-5. doi: 10.3945/ajcn.110.001941. Epub 2011 Feb 23.


Biological role, clinical significance, and therapeutic possibilities of the recently discovered metabolic hormone fibroblastic growth factor 21.

Iglesias P, Selgas R, Romero S, Díez JJ.

Eur J Endocrinol. 2012 Sep;167(3):301-9. doi: 10.1530/EJE-12-0357. Epub 2012 Jun 27. Review.


Retinoic acid receptor β stimulates hepatic induction of fibroblast growth factor 21 to promote fatty acid oxidation and control whole-body energy homeostasis in mice.

Li Y, Wong K, Walsh K, Gao B, Zang M.

J Biol Chem. 2013 Apr 12;288(15):10490-504. doi: 10.1074/jbc.M112.429852. Epub 2013 Feb 19.


FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting.

Liang Q, Zhong L, Zhang J, Wang Y, Bornstein SR, Triggle CR, Ding H, Lam KS, Xu A.

Diabetes. 2014 Dec;63(12):4064-75. doi: 10.2337/db14-0541. Epub 2014 Jul 14.


Fibroblast growth factor-21 regulates PPARγ activity and the antidiabetic actions of thiazolidinediones.

Dutchak PA, Katafuchi T, Bookout AL, Choi JH, Yu RT, Mangelsdorf DJ, Kliewer SA.

Cell. 2012 Feb 3;148(3):556-67. doi: 10.1016/j.cell.2011.11.062.


FGF21 is dispensable for hypothermia induced by fasting in mice.

Oishi K, Sakamoto K, Konishi M, Murata Y, Itoh N, Sei H.

Neuro Endocrinol Lett. 2010;31(2):198-202.


Fibroblast growth factor 21 improves insulin resistance and ameliorates renal injury in db/db mice.

Kim HW, Lee JE, Cha JJ, Hyun YY, Kim JE, Lee MH, Song HK, Nam DH, Han JY, Han SY, Han KH, Kang YS, Cha DR.

Endocrinology. 2013 Sep;154(9):3366-76. doi: 10.1210/en.2012-2276. Epub 2013 Jul 3.


FGF21 Is Not a Major Mediator for Bone Homeostasis or Metabolic Actions of PPARα and PPARγ Agonists.

Li X, Stanislaus S, Asuncion F, Niu QT, Chinookoswong N, Villasenor K, Wang J, Wong P, Boyce R, Dwyer D, Han CY, Chen MM, Liu B, Stolina M, Ke HZ, Ominsky MS, Véniant MM, Xu J.

J Bone Miner Res. 2017 Apr;32(4):834-845. doi: 10.1002/jbmr.2936. Epub 2016 Sep 9.


Fibroblast growth factor 21 regulates lipolysis in white adipose tissue but is not required for ketogenesis and triglyceride clearance in liver.

Hotta Y, Nakamura H, Konishi M, Murata Y, Takagi H, Matsumura S, Inoue K, Fushiki T, Itoh N.

Endocrinology. 2009 Oct;150(10):4625-33. doi: 10.1210/en.2009-0119. Epub 2009 Jul 9.


Fibroblast growth factor 21: an overview from a clinical perspective.

Rydén M.

Cell Mol Life Sci. 2009 Jul;66(13):2067-73. doi: 10.1007/s00018-009-0003-9. Epub 2009 Mar 11. Review.


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