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Applications of multiparametric flow cytometry: providing new insights into biology to bridge the gap between research discovery and clinical application.

Cesano A, Parkinson D.

Cytometry A. 2012 Sep;81(9):732-3. doi: 10.1002/cyto.a.22087. Epub 2012 Jun 21. No abstract available.


TCR-induced T cell activation leads to simultaneous phosphorylation at Y505 and Y394 of p56(lck) residues.

Nyakeriga AM, Garg H, Joshi A.

Cytometry A. 2012 Sep;81(9):797-805. doi: 10.1002/cyto.a.22070. Epub 2012 Jun 6.


Rapid tyrosine phosphorylation of Lck following ligation of the tumor-associated cell surface molecule A6H.

Labuda T, Gerwien J, Odum N, Dohlsten M.

Int Immunol. 1999 Mar;11(3):427-33.


Functional uncoupling of T-cell receptor engagement and Lck activation in anergic human thymic CD4+ T cells.

Fujimaki W, Iwashima M, Yagi J, Zhang H, Yagi H, Seo K, Imai Y, Imanishi K, Uchiyama T.

J Biol Chem. 2001 May 18;276(20):17455-60. Epub 2001 Feb 22.


Differential association of CD45 isoforms with CD4 and CD8 regulates the actions of specific pools of p56lck tyrosine kinase in T cell antigen receptor signal transduction.

Dornan S, Sebestyen Z, Gamble J, Nagy P, Bodnar A, Alldridge L, Doe S, Holmes N, Goff LK, Beverley P, Szollosi J, Alexander DR.

J Biol Chem. 2002 Jan 18;277(3):1912-8. Epub 2001 Nov 2.


Modulation of Lck function through multisite docking to T cell-specific adapter protein.

Granum S, Andersen TC, Sørlie M, Jørgensen M, Koll L, Berge T, Lea T, Fleckenstein B, Spurkland A, Sundvold-Gjerstad V.

J Biol Chem. 2008 Aug 8;283(32):21909-19. doi: 10.1074/jbc.M800871200. Epub 2008 Jun 9.


Interactions of CD45-associated protein with the antigen receptor signaling machinery in T-lymphocytes.

Veillette A, Soussou D, Latour S, Davidson D, Gervais FG.

J Biol Chem. 1999 May 14;274(20):14392-9.


Tyrosine 319 in the interdomain B of ZAP-70 is a binding site for the Src homology 2 domain of Lck.

Pelosi M, Di Bartolo V, Mounier V, Mège D, Pascussi JM, Dufour E, Blondel A, Acuto O.

J Biol Chem. 1999 May 14;274(20):14229-37.


Defective p56Lck activity in T cells from an adult patient with idiopathic CD4+ lymphocytopenia.

Hubert P, Bergeron F, Ferreira V, Seligmann M, Oksenhendler E, Debre P, Autran B.

Int Immunol. 2000 Apr;12(4):449-57.


T cells infiltrating non-Hodgkin's B cell lymphomas show altered tyrosine phosphorylation pattern even though T cell receptor/CD3-associated kinases are present.

Wang Q, Stanley J, Kudoh S, Myles J, Kolenko V, Yi T, Tubbs R, Bukowski R, Finke J.

J Immunol. 1995 Aug 1;155(3):1382-92.


Physical association of CD4 and CD45 in primary, resting CD4+ T cells.

Bonnard M, Maroun CR, Julius M.

Cell Immunol. 1997 Jan 10;175(1):1-11.


CD4+ CD45RA+ and CD4+ CD45RO+ T cells differ in their TCR-associated signaling responses.

Hall SR, Heffernan BM, Thompson NT, Rowan WC.

Eur J Immunol. 1999 Jul;29(7):2098-106.


The role of ezrin in T-cell receptor-dependent signaling.

Tomas EM, Darlington PJ, Chau LA, Madrenas J.

Transplant Proc. 2001 Feb-Mar;33(1-2):207-8. No abstract available.


Activation of naïve CD4 T cells by anti-CD3 reveals an important role for Fyn in Lck-mediated signaling.

Sugie K, Jeon MS, Grey HM.

Proc Natl Acad Sci U S A. 2004 Oct 12;101(41):14859-64. Epub 2004 Oct 1.


SOCS-6 negatively regulates T cell activation through targeting p56lck to proteasomal degradation.

Choi YB, Son M, Park M, Shin J, Yun Y.

J Biol Chem. 2010 Mar 5;285(10):7271-80. doi: 10.1074/jbc.M109.073726. Epub 2009 Dec 10.


Plasma membrane subdomain partitioning of Lck in primary human T lymphocytes.

Irles C, Arias-Martinez J, Guzmán-Bárcenas J, Ortega A.

Can J Physiol Pharmacol. 2010 Apr;88(4):487-96. doi: 10.1139/y09-125.


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