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Items: 1 to 20 of 73

2.
3.

alpha-Ketoglutarate dehydrogenase contributes to production of reactive oxygen species in glutamate-stimulated hippocampal neurons in situ.

Zündorf G, Kahlert S, Bunik VI, Reiser G.

Neuroscience. 2009 Jan 23;158(2):610-6. doi: 10.1016/j.neuroscience.2008.10.015. Epub 2008 Nov 1.

PMID:
18996448
4.

The alpha-ketoglutarate dehydrogenase complex in neurodegeneration.

Gibson GE, Park LC, Sheu KF, Blass JP, Calingasan NY.

Neurochem Int. 2000 Feb;36(2):97-112. Review.

PMID:
10676873
5.

The alpha-ketoglutarate dehydrogenase complex.

Sheu KF, Blass JP.

Ann N Y Acad Sci. 1999;893:61-78. Review.

PMID:
10672230
6.

Inhibition of the alpha-ketoglutarate dehydrogenase-mediated reactive oxygen species generation by lipoic acid.

Ambrus A, Tretter L, Adam-Vizi V.

J Neurochem. 2009 May;109 Suppl 1:222-9. doi: 10.1111/j.1471-4159.2009.05942.x.

7.

Consequences of the α-ketoglutarate dehydrogenase inhibition for neuronal metabolism and survival: implications for neurodegenerative diseases.

Trofimova LK, Araújo WL, Strokina AA, Fernie AR, Bettendorff L, Bunik VI.

Curr Med Chem. 2012;19(34):5895-906.

PMID:
23061627
8.
9.
10.

Reductions in the mitochondrial enzyme α-ketoglutarate dehydrogenase complex in neurodegenerative disease - beneficial or detrimental?

Chen H, Denton TT, Xu H, Calingasan N, Beal MF, Gibson GE.

J Neurochem. 2016 Dec;139(5):823-838. doi: 10.1111/jnc.13836.

11.

Metabolic impairment induces oxidative stress, compromises inflammatory responses, and inactivates a key mitochondrial enzyme in microglia.

Park LC, Zhang H, Sheu KF, Calingasan NY, Kristal BS, Lindsay JG, Gibson GE.

J Neurochem. 1999 May;72(5):1948-58.

12.
13.

Novel functions of the alpha-ketoglutarate dehydrogenase complex may mediate diverse oxidant-induced changes in mitochondrial enzymes associated with Alzheimer's disease.

Shi Q, Xu H, Kleinman WA, Gibson GE.

Biochim Biophys Acta. 2008 Apr;1782(4):229-38. doi: 10.1016/j.bbadis.2007.12.008. Epub 2007 Dec 31.

14.

Quantitative alpha-ketoglutarate dehydrogenase activity staining in brain sections and in cultured cells.

Park LC, Calingasan NY, Sheu KF, Gibson GE.

Anal Biochem. 2000 Jan 1;277(1):86-93.

PMID:
10610692
15.

Free radical-mediated neurotoxicity may be caused by inhibition of mitochondrial dehydrogenases in vitro and in vivo.

Sheline CT, Wei L.

Neuroscience. 2006 Jun 19;140(1):235-46. Epub 2006 Mar 23.

PMID:
16563643
16.

Alpha-ketoglutarate dehydrogenase complex-dependent succinylation of proteins in neurons and neuronal cell lines.

Gibson GE, Xu H, Chen HL, Chen W, Denton TT, Zhang S.

J Neurochem. 2015 Jul;134(1):86-96. doi: 10.1111/jnc.13096. Epub 2015 Apr 8.

17.

Abnormality of the alpha-ketoglutarate dehydrogenase complex in fibroblasts from familial Alzheimer's disease.

Sheu KF, Cooper AJ, Koike K, Koike M, Lindsay JG, Blass JP.

Ann Neurol. 1994 Mar;35(3):312-8.

PMID:
8122883
18.

Inactivation and reactivation of the mitochondrial α-ketoglutarate dehydrogenase complex.

Shi Q, Xu H, Yu H, Zhang N, Ye Y, Estevez AG, Deng H, Gibson GE.

J Biol Chem. 2011 May 20;286(20):17640-8. doi: 10.1074/jbc.M110.203018. Epub 2011 Mar 25.

19.

Reduction in the E2k subunit of the alpha-ketoglutarate dehydrogenase complex has effects independent of complex activity.

Shi Q, Chen HL, Xu H, Gibson GE.

J Biol Chem. 2005 Mar 25;280(12):10888-96. Epub 2005 Jan 12.

20.

An immunohistochemical study on alpha-ketoglutarate dehydrogenase complex in Parkinson's disease.

Mizuno Y, Matuda S, Yoshino H, Mori H, Hattori N, Ikebe S.

Ann Neurol. 1994 Feb;35(2):204-10.

PMID:
8109900

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