Format
Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 94

1.

Production and characterization of a colon cancer-specific immunotoxin based on the fungal ribotoxin α-sarcin.

Carreras-Sangrà N, Tomé-Amat J, García-Ortega L, Batt CA, Oñaderra M, Martínez-del-Pozo A, Gavilanes JG, Lacadena J.

Protein Eng Des Sel. 2012 Aug;25(8):425-35. doi: 10.1093/protein/gzs032. Epub 2012 Jun 19.

PMID:
22718791
2.

α-sarcin and RNase T1 based immunoconjugates: the role of intracellular trafficking in cytotoxic efficiency.

Tomé-Amat J, Ruiz-de-la-Herrán J, Martínez-del-Pozo Á, Gavilanes JG, Lacadena J.

FEBS J. 2015 Feb;282(4):673-84. doi: 10.1111/febs.13169. Epub 2014 Dec 26.

3.

Preparation of an engineered safer immunotoxin against colon carcinoma based on the ribotoxin hirsutellin A.

Tomé-Amat J, Herrero-Galán E, Oñaderra M, Martínez-Del-Pozo Á, Gavilanes JG, Lacadena J.

FEBS J. 2015 Jun;282(11):2131-41. doi: 10.1111/febs.13262. Epub 2015 Mar 27.

4.
5.

Secretion of recombinant pro- and mature fungal alpha-sarcin ribotoxin by the methylotrophic yeast Pichia pastoris: the Lys-Arg motif is required for maturation.

Martínez-Ruiz A, Martínez del Pozo A, Lacadena J, Mancheño JM, Oñaderra M, López-otín C, Gavilanes JG.

Protein Expr Purif. 1998 Apr;12(3):315-22.

PMID:
9535698
6.

Production and characterization of scFvA33T1, an immunoRNase targeting colon cancer cells.

Tomé-Amat J, Menéndez-Méndez A, García-Ortega L, Batt CA, Oñaderra M, Martínez-del-Pozo A, Gavilanes JG, Lacadena J.

FEBS J. 2012 Sep;279(17):3022-32. doi: 10.1111/j.1742-4658.2012.08683.x. Epub 2012 Jul 25.

7.

Efficient in vivo antitumor effect of an immunotoxin based on ribotoxin α-sarcin in nude mice bearing human colorectal cancer xenografts.

Tomé-Amat J, Olombrada M, Ruiz-de-la-Herrán J, Pérez-Gómez E, Andradas C, Sánchez C, Martínez L, Martínez-Del-Pozo Á, Gavilanes JG, Lacadena J.

Springerplus. 2015 Apr 8;4:168. doi: 10.1186/s40064-015-0943-5. eCollection 2015.

8.

Design, construction, and in vitro analysis of A33scFv::CDy, a recombinant fusion protein for antibody-directed enzyme prodrug therapy in colon cancer.

Coelho V, Dernedde J, Petrausch U, Panjideh H, Fuchs H, Menzel C, Dübel S, Keilholz U, Thiel E, Deckert PM.

Int J Oncol. 2007 Oct;31(4):951-7.

PMID:
17786329
9.

Antigen binding and cytotoxic properties of a recombinant immunotoxin incorporating the lytic peptide, melittin.

Dunn RD, Weston KM, Longhurst TJ, Lilley GG, Rivett DE, Hudson PJ, Raison RL.

Immunotechnology. 1996 Sep;2(3):229-40.

PMID:
9373315
10.

Deletion of the NH2-terminal beta-hairpin of the ribotoxin alpha-sarcin produces a nontoxic but active ribonuclease.

Garcia-Ortega L, Masip M, Mancheño JM, Oñaderra M, Lizarbe MA, García-Mayoral MF, Bruix M, Martínez del Pozo A, Gavilanes JG.

J Biol Chem. 2002 May 24;277(21):18632-9. Epub 2002 Mar 15.

12.

Expression, purification, and characterization of an immunotoxin containing a humanized anti-CD25 single-chain fragment variable antibody fused to a modified truncated Pseudomonas exotoxin A.

Wang H, Dai J, Li B, Fan K, Peng L, Zhang D, Cao Z, Qian W, Wang H, Zhao J, Guo Y.

Protein Expr Purif. 2008 Mar;58(1):140-7. Epub 2007 Sep 19.

PMID:
17950620
13.

Conserved asparagine residue 54 of alpha-sarcin plays a role in protein stability and enzyme activity.

Siemer A, Masip M, Carreras N, García-Ortega L, Oñaderra M, Bruix M, Del Pozo AM, Gavilanes JG.

Biol Chem. 2004 Dec;385(12):1165-70.

PMID:
15653429
14.

Expression, purification, and refolding of a novel immunotoxin containing humanized single-chain fragment variable antibody against CTLA4 and the N-terminal fragment of human perforin.

Wan L, Zeng L, Chen L, Huang Q, Li S, Lu Y, Li Y, Cheng J, Lu X.

Protein Expr Purif. 2006 Aug;48(2):307-13. Epub 2006 Mar 9.

PMID:
16584889
15.

Synthesis and purification of a toxin-linked conjugate targeting epidermal growth factor receptor in Escherichia coli.

Ma C, Li Y, Li Z, Huang H, Xu K, Xu H, Bai J, Li X, Zhao G.

Protein Expr Purif. 2012 May;83(1):1-7. doi: 10.1016/j.pep.2012.02.011. Epub 2012 Feb 20.

PMID:
22381467
16.

In vitro and in vivo anti-tumor activities of anti-EGFR single-chain variable fragment fused with recombinant gelonin toxin.

Zhou X, Qiu J, Wang Z, Huang N, Li X, Li Q, Zhang Y, Zhao C, Luo C, Zhang N, Teng X, Chen Z, Liu X, Yu X, Wu W, Wei YQ, Li J.

J Cancer Res Clin Oncol. 2012 Jul;138(7):1081-90. doi: 10.1007/s00432-012-1181-7. Epub 2012 Mar 7.

PMID:
22392077
17.

Role of histidine-50, glutamic acid-96, and histidine-137 in the ribonucleolytic mechanism of the ribotoxin alpha-sarcin.

Lacadena J, Martínez del Pozo A, Martínez-Ruiz A, Pérez-Cañadillas JM, Bruix M, Mancheño JM, Oñaderra M, Gavilanes JG.

Proteins. 1999 Nov 15;37(3):474-84.

PMID:
10591106
18.
19.
20.

Leucine 145 of the ribotoxin alpha-sarcin plays a key role for determining the specificity of the ribosome-inactivating activity of the protein.

Masip M, García-Ortega L, Olmo N, García-Mayoral MF, Pérez-Cañadillas JM, Bruix M, Oñaderra M, Martínez del Pozo A, Gavilanes JG.

Protein Sci. 2003 Jan;12(1):161-9.

Supplemental Content

Support Center