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Items: 1 to 20 of 116

1.

Bone morphogenetic protein signaling in vascular disease: anti-inflammatory action through myocardin-related transcription factor A.

Wang D, Prakash J, Nguyen P, Davis-Dusenbery BN, Hill NS, Layne MD, Hata A, Lagna G.

J Biol Chem. 2012 Aug 10;287(33):28067-77. doi: 10.1074/jbc.M112.379487. Epub 2012 Jun 20.

2.

Control of phenotypic plasticity of smooth muscle cells by bone morphogenetic protein signaling through the myocardin-related transcription factors.

Lagna G, Ku MM, Nguyen PH, Neuman NA, Davis BN, Hata A.

J Biol Chem. 2007 Dec 21;282(51):37244-55. Epub 2007 Oct 17.

3.

down-regulation of Kruppel-like factor-4 (KLF4) by microRNA-143/145 is critical for modulation of vascular smooth muscle cell phenotype by transforming growth factor-beta and bone morphogenetic protein 4.

Davis-Dusenbery BN, Chan MC, Reno KE, Weisman AS, Layne MD, Lagna G, Hata A.

J Biol Chem. 2011 Aug 12;286(32):28097-110. doi: 10.1074/jbc.M111.236950. Epub 2011 Jun 13.

4.

Transforming growth factor-β(1) represses bone morphogenetic protein-mediated Smad signaling in pulmonary artery smooth muscle cells via Smad3.

Upton PD, Davies RJ, Tajsic T, Morrell NW.

Am J Respir Cell Mol Biol. 2013 Dec;49(6):1135-45. doi: 10.1165/rcmb.2012-0470OC.

5.

Sildenafil potentiates bone morphogenetic protein signaling in pulmonary arterial smooth muscle cells and in experimental pulmonary hypertension.

Yang J, Li X, Al-Lamki RS, Wu C, Weiss A, Berk J, Schermuly RT, Morrell NW.

Arterioscler Thromb Vasc Biol. 2013 Jan;33(1):34-42. doi: 10.1161/ATVBAHA.112.300121. Epub 2012 Nov 8.

6.

Endothelin-Bone morphogenetic protein type 2 receptor interaction induces pulmonary artery smooth muscle cell hyperplasia in pulmonary arterial hypertension.

Maruyama H, Dewachter C, Belhaj A, Rondelet B, Sakai S, Remmelink M, Vachiery JL, Naeije R, Dewachter L.

J Heart Lung Transplant. 2015 Mar;34(3):468-78. doi: 10.1016/j.healun.2014.09.011. Epub 2014 Sep 28.

PMID:
25447587
7.

Codependence of Bone Morphogenetic Protein Receptor 2 and Transforming Growth Factor-β in Elastic Fiber Assembly and Its Perturbation in Pulmonary Arterial Hypertension.

Tojais NF, Cao A, Lai YJ, Wang L, Chen PI, Alcazar MAA, de Jesus Perez VA, Hopper RK, Rhodes CJ, Bill MA, Sakai LY, Rabinovitch M.

Arterioscler Thromb Vasc Biol. 2017 Aug;37(8):1559-1569. doi: 10.1161/ATVBAHA.117.309696. Epub 2017 Jun 15.

8.

Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo.

Yang J, Li X, Al-Lamki RS, Southwood M, Zhao J, Lever AM, Grimminger F, Schermuly RT, Morrell NW.

Circ Res. 2010 Jul 23;107(2):252-62. doi: 10.1161/CIRCRESAHA.109.209940. Epub 2010 Jun 3.

9.

Critical role for the advanced glycation end-products receptor in pulmonary arterial hypertension etiology.

Meloche J, Courchesne A, Barrier M, Carter S, Bisserier M, Paulin R, Lauzon-Joset JF, Breuils-Bonnet S, Tremblay É, Biardel S, Racine C, Courture C, Bonnet P, Majka SM, Deshaies Y, Picard F, Provencher S, Bonnet S.

J Am Heart Assoc. 2013 Jan 16;2(1):e005157. doi: 10.1161/JAHA.112.005157.

10.

Dexamethasone induces apoptosis in pulmonary arterial smooth muscle cells.

Price LC, Shao D, Meng C, Perros F, Garfield BE, Zhu J, Montani D, Dorfmuller P, Humbert M, Adcock IM, Wort SJ.

Respir Res. 2015 Sep 18;16:114. doi: 10.1186/s12931-015-0262-y.

11.

Involvement of the bone morphogenetic protein system in endothelin- and aldosterone-induced cell proliferation of pulmonary arterial smooth muscle cells isolated from human patients with pulmonary arterial hypertension.

Yamanaka R, Otsuka F, Nakamura K, Yamashita M, Otani H, Takeda M, Matsumoto Y, Kusano KF, Ito H, Makino H.

Hypertens Res. 2010 May;33(5):435-45. doi: 10.1038/hr.2010.16. Epub 2010 Feb 26.

PMID:
20186146
12.

Dysfunctional Smad signaling contributes to abnormal smooth muscle cell proliferation in familial pulmonary arterial hypertension.

Yang X, Long L, Southwood M, Rudarakanchana N, Upton PD, Jeffery TK, Atkinson C, Chen H, Trembath RC, Morrell NW.

Circ Res. 2005 May 27;96(10):1053-63. Epub 2005 Apr 21.

13.

Mutations in bone morphogenetic protein type II receptor cause dysregulation of Id gene expression in pulmonary artery smooth muscle cells: implications for familial pulmonary arterial hypertension.

Yang J, Davies RJ, Southwood M, Long L, Yang X, Sobolewski A, Upton PD, Trembath RC, Morrell NW.

Circ Res. 2008 May 23;102(10):1212-21. doi: 10.1161/CIRCRESAHA.108.173567. Epub 2008 Apr 24.

14.

Deletion of the sequence encoding the tail domain of the bone morphogenetic protein type 2 receptor reveals a bone morphogenetic protein 7-specific gain of function.

Leyton PA, Beppu H, Pappas A, Martyn TM, Derwall M, Baron DM, Galdos R, Bloch DB, Bloch KD.

PLoS One. 2013 Oct 8;8(10):e76947. doi: 10.1371/journal.pone.0076947. eCollection 2013.

15.

Id proteins are critical downstream effectors of BMP signaling in human pulmonary arterial smooth muscle cells.

Yang J, Li X, Li Y, Southwood M, Ye L, Long L, Al-Lamki RS, Morrell NW.

Am J Physiol Lung Cell Mol Physiol. 2013 Aug 15;305(4):L312-21. doi: 10.1152/ajplung.00054.2013. Epub 2013 Jun 14.

16.

Inhibition of nuclear factor-κB in the lungs prevents monocrotaline-induced pulmonary hypertension in mice.

Li L, Wei C, Kim IK, Janssen-Heininger Y, Gupta S.

Hypertension. 2014 Jun;63(6):1260-9. doi: 10.1161/HYPERTENSIONAHA.114.03220. Epub 2014 Mar 10.

17.

BMP pathway regulation of and by macrophages.

Talati M, West J, Zaynagetdinov R, Hong CC, Han W, Blackwell T, Robinson L, Blackwell TS, Lane K.

PLoS One. 2014 Apr 8;9(4):e94119. doi: 10.1371/journal.pone.0094119. eCollection 2014. Erratum in: PLoS One. 2014;9(6):e101543.

18.

SMAD1 deficiency in either endothelial or smooth muscle cells can predispose mice to pulmonary hypertension.

Han C, Hong KH, Kim YH, Kim MJ, Song C, Kim MJ, Kim SJ, Raizada MK, Oh SP.

Hypertension. 2013 May;61(5):1044-52. doi: 10.1161/HYPERTENSIONAHA.111.199158. Epub 2013 Mar 11.

19.

Correction of nonsense BMPR2 and SMAD9 mutations by ataluren in pulmonary arterial hypertension.

Drake KM, Dunmore BJ, McNelly LN, Morrell NW, Aldred MA.

Am J Respir Cell Mol Biol. 2013 Sep;49(3):403-9. doi: 10.1165/rcmb.2013-0100OC.

20.

Tenascin-C is induced by mutated BMP type II receptors in familial forms of pulmonary arterial hypertension.

Ihida-Stansbury K, McKean DM, Lane KB, Loyd JE, Wheeler LA, Morrell NW, Jones PL.

Am J Physiol Lung Cell Mol Physiol. 2006 Oct;291(4):L694-702. Epub 2006 Jun 16.

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