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Items: 1 to 20 of 129


Sphingosine 1-phosphate receptor 5 mediates the immune quiescence of the human brain endothelial barrier.

van Doorn R, Lopes Pinheiro MA, Kooij G, Lakeman K, van het Hof B, van der Pol SM, Geerts D, van Horssen J, van der Valk P, van der Kam E, Ronken E, Reijerkerk A, de Vries HE.

J Neuroinflammation. 2012 Jun 20;9:133. doi: 10.1186/1742-2094-9-133.


Structural pathways for macromolecular and cellular transport across the blood-brain barrier during inflammatory conditions. Review.

Lossinsky AS, Shivers RR.

Histol Histopathol. 2004 Apr;19(2):535-64. doi: 10.14670/HH-19.535. Review.


Sphingosine 1 Phosphate at the Blood Brain Barrier: Can the Modulation of S1P Receptor 1 Influence the Response of Endothelial Cells and Astrocytes to Inflammatory Stimuli?

Spampinato SF, Obermeier B, Cotleur A, Love A, Takeshita Y, Sano Y, Kanda T, Ransohoff RM.

PLoS One. 2015 Jul 21;10(7):e0133392. doi: 10.1371/journal.pone.0133392. eCollection 2015.


Statins reduce human blood-brain barrier permeability and restrict leukocyte migration: relevance to multiple sclerosis.

Ifergan I, Wosik K, Cayrol R, Kébir H, Auger C, Bernard M, Bouthillier A, Moumdjian R, Duquette P, Prat A.

Ann Neurol. 2006 Jul;60(1):45-55.


Poly(ADP-ribose) polymerase-1 inhibition in brain endothelium protects the blood-brain barrier under physiologic and neuroinflammatory conditions.

Rom S, Zuluaga-Ramirez V, Dykstra H, Reichenbach NL, Ramirez SH, Persidsky Y.

J Cereb Blood Flow Metab. 2015 Jan;35(1):28-36. doi: 10.1038/jcbfm.2014.167. Epub 2014 Sep 24.


Discovery of A-971432, An Orally Bioavailable Selective Sphingosine-1-Phosphate Receptor 5 (S1P5) Agonist for the Potential Treatment of Neurodegenerative Disorders.

Hobson AD, Harris CM, van der Kam EL, Turner SC, Abibi A, Aguirre AL, Bousquet P, Kebede T, Konopacki DB, Gintant G, Kim Y, Larson K, Maull JW, Moore NS, Shi D, Shrestha A, Tang X, Zhang P, Sarris KK.

J Med Chem. 2015 Dec 10;58(23):9154-70. doi: 10.1021/acs.jmedchem.5b00928. Epub 2015 Nov 23.


Edg8/S1P5: an oligodendroglial receptor with dual function on process retraction and cell survival.

Jaillard C, Harrison S, Stankoff B, Aigrot MS, Calver AR, Duddy G, Walsh FS, Pangalos MN, Arimura N, Kaibuchi K, Zalc B, Lubetzki C.

J Neurosci. 2005 Feb 9;25(6):1459-69.


Differential involvement of ezrin/radixin/moesin proteins in sphingosine 1-phosphate-induced human pulmonary endothelial cell barrier enhancement.

Adyshev DM, Moldobaeva NK, Elangovan VR, Garcia JG, Dudek SM.

Cell Signal. 2011 Dec;23(12):2086-96. doi: 10.1016/j.cellsig.2011.08.003. Epub 2011 Aug 12.


Photolysis of caged sphingosine-1-phosphate induces barrier enhancement and intracellular activation of lung endothelial cell signaling pathways.

Usatyuk PV, He D, Bindokas V, Gorshkova IA, Berdyshev EV, Garcia JG, Natarajan V.

Am J Physiol Lung Cell Mol Physiol. 2011 Jun;300(6):L840-50. doi: 10.1152/ajplung.00404.2010. Epub 2011 Apr 8.


Sphingosine 1-phosphate signaling at the blood-brain barrier.

Prager B, Spampinato SF, Ransohoff RM.

Trends Mol Med. 2015 Jun;21(6):354-63. doi: 10.1016/j.molmed.2015.03.006. Epub 2015 May 1.


The role of shear stress in Blood-Brain Barrier endothelial physiology.

Cucullo L, Hossain M, Puvenna V, Marchi N, Janigro D.

BMC Neurosci. 2011 May 11;12:40. doi: 10.1186/1471-2202-12-40.


Protein S controls hypoxic/ischemic blood-brain barrier disruption through the TAM receptor Tyro3 and sphingosine 1-phosphate receptor.

Zhu D, Wang Y, Singh I, Bell RD, Deane R, Zhong Z, Sagare A, Winkler EA, Zlokovic BV.

Blood. 2010 Jun 10;115(23):4963-72. doi: 10.1182/blood-2010-01-262386. Epub 2010 Mar 26.


CXCL12-induced monocyte-endothelial interactions promote lymphocyte transmigration across an in vitro blood-brain barrier.

Man S, Tucky B, Cotleur A, Drazba J, Takeshita Y, Ransohoff RM.

Sci Transl Med. 2012 Feb 1;4(119):119ra14. doi: 10.1126/scitranslmed.3003197.


Human brain endothelial cells endeavor to immunoregulate CD8 T cells via PD-1 ligand expression in multiple sclerosis.

Pittet CL, Newcombe J, Prat A, Arbour N.

J Neuroinflammation. 2011 Nov 8;8:155. doi: 10.1186/1742-2094-8-155.


ECIS technology reveals that monocytes isolated by CD14+ve selection mediate greater loss of BBB integrity than untouched monocytes, which occurs to a greater extent with IL-1β activated endothelium in comparison to TNFα.

Kho DT, Johnson R, Robilliard L, du Mez E, McIntosh J, O'Carroll SJ, Angel CE, Graham ES.

PLoS One. 2017 Jul 21;12(7):e0180267. doi: 10.1371/journal.pone.0180267. eCollection 2017.


Regulation of human cerebro-microvascular endothelial baso-lateral adhesion and barrier function by S1P through dual involvement of S1P1 and S1P2 receptors.

Wiltshire R, Nelson V, Kho DT, Angel CE, O'Carroll SJ, Graham ES.

Sci Rep. 2016 Jan 27;6:19814. doi: 10.1038/srep19814.


A dynamic in vitro BBB model for the study of immune cell trafficking into the central nervous system.

Cucullo L, Marchi N, Hossain M, Janigro D.

J Cereb Blood Flow Metab. 2011 Feb;31(2):767-77. doi: 10.1038/jcbfm.2010.162. Epub 2010 Sep 15.


Sphingosine-1-phosphate prevents tumor necrosis factor-{alpha}-mediated monocyte adhesion to aortic endothelium in mice.

Bolick DT, Srinivasan S, Kim KW, Hatley ME, Clemens JJ, Whetzel A, Ferger N, Macdonald TL, Davis MD, Tsao PS, Lynch KR, Hedrick CC.

Arterioscler Thromb Vasc Biol. 2005 May;25(5):976-81. Epub 2005 Mar 10.

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