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Items: 1 to 20 of 134

1.

Genetic variation in T-box binding element functionally affects SCN5A/SCN10A enhancer.

van den Boogaard M, Wong LY, Tessadori F, Bakker ML, Dreizehnter LK, Wakker V, Bezzina CR, 't Hoen PA, Bakkers J, Barnett P, Christoffels VM.

J Clin Invest. 2012 Jul;122(7):2519-30. doi: 10.1172/JCI62613. Epub 2012 Jun 18.

2.

From GWAS to function: genetic variation in sodium channel gene enhancer influences electrical patterning.

van den Boogaard M, Barnett P, Christoffels VM.

Trends Cardiovasc Med. 2014 Apr;24(3):99-104. doi: 10.1016/j.tcm.2013.09.001. Epub 2013 Dec 17. Review.

PMID:
24360055
3.

A common genetic variant within SCN10A modulates cardiac SCN5A expression.

van den Boogaard M, Smemo S, Burnicka-Turek O, Arnolds DE, van de Werken HJ, Klous P, McKean D, Muehlschlegel JD, Moosmann J, Toka O, Yang XH, Koopmann TT, Adriaens ME, Bezzina CR, de Laat W, Seidman C, Seidman JG, Christoffels VM, Nobrega MA, Barnett P, Moskowitz IP.

J Clin Invest. 2014 Apr;124(4):1844-52. doi: 10.1172/JCI73140. Epub 2014 Mar 18.

4.

TBX5 drives Scn5a expression to regulate cardiac conduction system function.

Arnolds DE, Liu F, Fahrenbach JP, Kim GH, Schillinger KJ, Smemo S, McNally EM, Nobrega MA, Patel VV, Moskowitz IP.

J Clin Invest. 2012 Jul;122(7):2509-18. doi: 10.1172/JCI62617. Epub 2012 Jun 25.

5.

A large permissive regulatory domain exclusively controls Tbx3 expression in the cardiac conduction system.

van Weerd JH, Badi I, van den Boogaard M, Stefanovic S, van de Werken HJ, Gomez-Velazquez M, Badia-Careaga C, Manzanares M, de Laat W, Barnett P, Christoffels VM.

Circ Res. 2014 Aug 1;115(4):432-41. doi: 10.1161/CIRCRESAHA.115.303591. Epub 2014 Jun 24.

6.

Gene regulatory elements of the cardiac conduction system.

van Duijvenboden K, Ruijter JM, Christoffels VM.

Brief Funct Genomics. 2014 Jan;13(1):28-38. doi: 10.1093/bfgp/elt031. Epub 2013 Aug 22. Review.

PMID:
23969024
7.

Nav-igating through a complex landscape: SCN10A and cardiac conduction.

Park DS, Fishman GI.

J Clin Invest. 2014 Apr;124(4):1460-2. doi: 10.1172/JCI75240. Epub 2014 Mar 18.

8.

Co-occupancy by multiple cardiac transcription factors identifies transcriptional enhancers active in heart.

He A, Kong SW, Ma Q, Pu WT.

Proc Natl Acad Sci U S A. 2011 Apr 5;108(14):5632-7. doi: 10.1073/pnas.1016959108. Epub 2011 Mar 17.

9.

A transgenic zebrafish model of a human cardiac sodium channel mutation exhibits bradycardia, conduction-system abnormalities and early death.

Huttner IG, Trivedi G, Jacoby A, Mann SA, Vandenberg JI, Fatkin D.

J Mol Cell Cardiol. 2013 Aug;61:123-32. doi: 10.1016/j.yjmcc.2013.06.005. Epub 2013 Jun 19.

PMID:
23791817
10.

Genetic variation in SCN10A influences cardiac conduction.

Chambers JC, Zhao J, Terracciano CM, Bezzina CR, Zhang W, Kaba R, Navaratnarajah M, Lotlikar A, Sehmi JS, Kooner MK, Deng G, Siedlecka U, Parasramka S, El-Hamamsy I, Wass MN, Dekker LR, de Jong JS, Sternberg MJ, McKenna W, Severs NJ, de Silva R, Wilde AA, Anand P, Yacoub M, Scott J, Elliott P, Wood JN, Kooner JS.

Nat Genet. 2010 Feb;42(2):149-52. doi: 10.1038/ng.516. Epub 2010 Jan 10.

PMID:
20062061
11.

Msx1 and Msx2 are functional interacting partners of T-box factors in the regulation of Connexin43.

Boogerd KJ, Wong LY, Christoffels VM, Klarenbeek M, Ruijter JM, Moorman AF, Barnett P.

Cardiovasc Res. 2008 Jun 1;78(3):485-93. doi: 10.1093/cvr/cvn049. Epub 2008 Feb 19.

PMID:
18285513
12.
13.

The cardiac sodium channel displays differential distribution in the conduction system and transmural heterogeneity in the murine ventricular myocardium.

Remme CA, Verkerk AO, Hoogaars WM, Aanhaanen WT, Scicluna BP, Annink C, van den Hoff MJ, Wilde AA, van Veen TA, Veldkamp MW, de Bakker JM, Christoffels VM, Bezzina CR.

Basic Res Cardiol. 2009 Sep;104(5):511-22. doi: 10.1007/s00395-009-0012-8. Epub 2009 Mar 3.

14.

Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.

Bezzina CR, Barc J, Mizusawa Y, Remme CA, Gourraud JB, Simonet F, Verkerk AO, Schwartz PJ, Crotti L, Dagradi F, Guicheney P, Fressart V, Leenhardt A, Antzelevitch C, Bartkowiak S, Borggrefe M, Schimpf R, Schulze-Bahr E, Zumhagen S, Behr ER, Bastiaenen R, Tfelt-Hansen J, Olesen MS, Kääb S, Beckmann BM, Weeke P, Watanabe H, Endo N, Minamino T, Horie M, Ohno S, Hasegawa K, Makita N, Nogami A, Shimizu W, Aiba T, Froguel P, Balkau B, Lantieri O, Torchio M, Wiese C, Weber D, Wolswinkel R, Coronel R, Boukens BJ, Bézieau S, Charpentier E, Chatel S, Despres A, Gros F, Kyndt F, Lecointe S, Lindenbaum P, Portero V, Violleau J, Gessler M, Tan HL, Roden DM, Christoffels VM, Le Marec H, Wilde AA, Probst V, Schott JJ, Dina C, Redon R.

Nat Genet. 2013 Sep;45(9):1044-9. doi: 10.1038/ng.2712. Epub 2013 Jul 21. Erratum in: Nat Genet. 2013 Nov;45(11):1409. Borggrefe, Martin [added]; Schimpf, Rainer [added].

15.

Reactive oxygen species suppress cardiac NaV1.5 expression through Foxo1.

Mao W, You T, Ye B, Li X, Dong HH, Hill JA, Li F, Xu H.

PLoS One. 2012;7(2):e32738. doi: 10.1371/journal.pone.0032738. Epub 2012 Feb 29.

16.

A heterozygous deletion mutation in the cardiac sodium channel gene SCN5A with loss- and gain-of-function characteristics manifests as isolated conduction disease, without signs of Brugada or long QT syndrome.

Zumhagen S, Veldkamp MW, Stallmeyer B, Baartscheer A, Eckardt L, Paul M, Remme CA, Bhuiyan ZA, Bezzina CR, Schulze-Bahr E.

PLoS One. 2013 Jun 28;8(6):e67963. doi: 10.1371/journal.pone.0067963. Print 2013.

17.

Cx30.2 enhancer analysis identifies Gata4 as a novel regulator of atrioventricular delay.

Munshi NV, McAnally J, Bezprozvannaya S, Berry JM, Richardson JA, Hill JA, Olson EN.

Development. 2009 Aug;136(15):2665-74. doi: 10.1242/dev.038562.

18.

Role of common and rare variants in SCN10A: results from the Brugada syndrome QRS locus gene discovery collaborative study.

Behr ER, Savio-Galimberti E, Barc J, Holst AG, Petropoulou E, Prins BP, Jabbari J, Torchio M, Berthet M, Mizusawa Y, Yang T, Nannenberg EA, Dagradi F, Weeke P, Bastiaenan R, Ackerman MJ, Haunso S, Leenhardt A, Kääb S, Probst V, Redon R, Sharma S, Wilde A, Tfelt-Hansen J, Schwartz P, Roden DM, Bezzina CR, Olesen M, Darbar D, Guicheney P, Crotti L; UK10K Consortium, Jamshidi Y.

Cardiovasc Res. 2015 Jun 1;106(3):520-9. doi: 10.1093/cvr/cvv042. Epub 2015 Feb 17. Erratum in: Cardiovasc Res. 2016 May 1;110(1):3.

19.

The transcriptional repressor Tbx3 delineates the developing central conduction system of the heart.

Hoogaars WM, Tessari A, Moorman AF, de Boer PA, Hagoort J, Soufan AT, Campione M, Christoffels VM.

Cardiovasc Res. 2004 Jun 1;62(3):489-99.

PMID:
15158141
20.

Contrasting Nav1.8 Activity in Scn10a-/- Ventricular Myocytes and the Intact Heart.

Stroud DM, Yang T, Bersell K, Kryshtal DO, Nagao S, Shaffer C, Short L, Hall L, Atack TC, Zhang W, Knollmann BC, Baudenbacher F, Roden DM.

J Am Heart Assoc. 2016 Nov 2;5(11). pii: e002946.

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