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Items: 1 to 20 of 195

1.

Phosphoinositide 3-kinase p110α is a master regulator of exercise-induced cardioprotection and PI3K gene therapy rescues cardiac dysfunction.

Weeks KL, Gao X, Du XJ, Boey EJ, Matsumoto A, Bernardo BC, Kiriazis H, Cemerlang N, Tan JW, Tham YK, Franke TF, Qian H, Bogoyevitch MA, Woodcock EA, Febbraio MA, Gregorevic P, McMullen JR.

Circ Heart Fail. 2012 Jul 1;5(4):523-34. doi: 10.1161/CIRCHEARTFAILURE.112.966622. Epub 2012 Jun 15.

2.

Phosphoinositide 3-kinase (p110α) gene delivery limits diabetes-induced cardiac NADPH oxidase and cardiomyopathy in a mouse model with established diastolic dysfunction.

Prakoso D, De Blasio MJ, Qin C, Rosli S, Kiriazis H, Qian H, Du XJ, Weeks KL, Gregorevic P, McMullen JR, Ritchie RH.

Clin Sci (Lond). 2017 Jun 7;131(12):1345-1360. doi: 10.1042/CS20170063. Print 2017 Jun 1.

PMID:
28487469
3.

PI3K(p110 alpha) protects against myocardial infarction-induced heart failure: identification of PI3K-regulated miRNA and mRNA.

Lin RC, Weeks KL, Gao XM, Williams RB, Bernardo BC, Kiriazis H, Matthews VB, Woodcock EA, Bouwman RD, Mollica JP, Speirs HJ, Dawes IW, Daly RJ, Shioi T, Izumo S, Febbraio MA, Du XJ, McMullen JR.

Arterioscler Thromb Vasc Biol. 2010 Apr;30(4):724-32. doi: 10.1161/ATVBAHA.109.201988.

4.

Enhanced phosphoinositide 3-kinase(p110α) activity prevents diabetes-induced cardiomyopathy and superoxide generation in a mouse model of diabetes.

Ritchie RH, Love JE, Huynh K, Bernardo BC, Henstridge DC, Kiriazis H, Tham YK, Sapra G, Qin C, Cemerlang N, Boey EJ, Jandeleit-Dahm K, Du XJ, McMullen JR.

Diabetologia. 2012 Dec;55(12):3369-81. doi: 10.1007/s00125-012-2720-0. Epub 2012 Sep 22.

PMID:
23001375
5.

Toll-like receptor-2 mediates adaptive cardiac hypertrophy in response to pressure overload through interleukin-1β upregulation via nuclear factor κB activation.

Higashikuni Y, Tanaka K, Kato M, Nureki O, Hirata Y, Nagai R, Komuro I, Sata M.

J Am Heart Assoc. 2013 Nov 18;2(6):e000267. doi: 10.1161/JAHA.113.000267.

6.

Protective effects of exercise and phosphoinositide 3-kinase(p110alpha) signaling in dilated and hypertrophic cardiomyopathy.

McMullen JR, Amirahmadi F, Woodcock EA, Schinke-Braun M, Bouwman RD, Hewitt KA, Mollica JP, Zhang L, Zhang Y, Shioi T, Buerger A, Izumo S, Jay PY, Jennings GL.

Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):612-7. Epub 2007 Jan 3.

7.

Reduced phosphoinositide 3-kinase (p110alpha) activation increases the susceptibility to atrial fibrillation.

Pretorius L, Du XJ, Woodcock EA, Kiriazis H, Lin RC, Marasco S, Medcalf RL, Ming Z, Head GA, Tan JW, Cemerlang N, Sadoshima J, Shioi T, Izumo S, Lukoshkova EV, Dart AM, Jennings GL, McMullen JR.

Am J Pathol. 2009 Sep;175(3):998-1009. doi: 10.2353/ajpath.2009.090126. Epub 2009 Aug 13.

8.

Activation of myocardial phosphoinositide-3-kinase p110α ameliorates cardiac dysfunction and improves survival in polymicrobial sepsis.

Li C, Hua F, Ha T, Singh K, Lu C, Kalbfleisch J, Breuel KF, Ford T, Kao RL, Gao M, Ozment TR, Williams DL.

PLoS One. 2012;7(9):e44712. doi: 10.1371/journal.pone.0044712. Epub 2012 Sep 19.

9.

Osteopontin RNA aptamer can prevent and reverse pressure overload-induced heart failure.

Li J, Yousefi K, Ding W, Singh J, Shehadeh LA.

Cardiovasc Res. 2017 May 1;113(6):633-643. doi: 10.1093/cvr/cvx016.

PMID:
28453726
10.

K(ATP) activation prevents progression of cardiac hypertrophy to failure induced by pressure overload via protecting endothelial function.

Gao S, Long CL, Wang RH, Wang H.

Cardiovasc Res. 2009 Aug 1;83(3):444-56. doi: 10.1093/cvr/cvp099. Epub 2009 Mar 20.

PMID:
19304734
11.

Gelsolin regulates cardiac remodeling after myocardial infarction through DNase I-mediated apoptosis.

Li GH, Shi Y, Chen Y, Sun M, Sader S, Maekawa Y, Arab S, Dawood F, Chen M, De Couto G, Liu Y, Fukuoka M, Yang S, Da Shi M, Kirshenbaum LA, McCulloch CA, Liu P.

Circ Res. 2009 Apr 10;104(7):896-904. doi: 10.1161/CIRCRESAHA.108.172882. Epub 2009 Feb 26.

12.

Diacylglycerol kinase-epsilon restores cardiac dysfunction under chronic pressure overload: a new specific regulator of Galpha(q) signaling cascade.

Niizeki T, Takeishi Y, Kitahara T, Arimoto T, Ishino M, Bilim O, Suzuki S, Sasaki T, Nakajima O, Walsh RA, Goto K, Kubota I.

Am J Physiol Heart Circ Physiol. 2008 Jul;295(1):H245-55. doi: 10.1152/ajpheart.00066.2008. Epub 2008 May 16.

13.

No contribution of IP3-R(2) to disease phenotype in models of dilated cardiomyopathy or pressure overload hypertrophy.

Cooley N, Ouyang K, McMullen JR, Kiriazis H, Sheikh F, Wu W, Mu Y, Du XJ, Chen J, Woodcock EA.

Circ Heart Fail. 2013 Mar;6(2):318-25. doi: 10.1161/CIRCHEARTFAILURE.112.972158. Epub 2012 Dec 20.

14.

Overexpression of coupling factor 6 attenuates exercise-induced physiological cardiac hypertrophy by inhibiting PI3K/Akt signaling in mice.

Sagara S, Osanai T, Itoh T, Izumiyama K, Shibutani S, Hanada K, Yokoyama H, Yamamoto Y, Yokota T, Tomita H, Magota K, Okumura K.

J Hypertens. 2012 Apr;30(4):778-86. doi: 10.1097/HJH.0b013e3283505101.

PMID:
22306848
15.

The protective effects of exercise and phosphoinositide 3-kinase (p110alpha) in the failing heart.

Owen KL, Pretorius L, McMullen JR.

Clin Sci (Lond). 2009 Mar;116(5):365-75. doi: 10.1042/CS20080183. Review.

PMID:
19175355
16.

Cardiac remodeling caused by transgenic overexpression of a corn Rac gene.

Elnakish MT, Awad MM, Hassona MD, Alhaj MA, Kulkarni A, Citro LA, Sayyid M, Abouelnaga ZA, El-Sayed O, Kuppusamy P, Moldovan L, Khan M, Hassanain HH.

Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H868-80. doi: 10.1152/ajpheart.00807.2010. Epub 2011 May 27.

17.

Detrimental effect of combined exercise training and eNOS overexpression on cardiac function after myocardial infarction.

de Waard MC, van der Velden J, Boontje NM, Dekkers DH, van Haperen R, Kuster DW, Lamers JM, de Crom R, Duncker DJ.

Am J Physiol Heart Circ Physiol. 2009 May;296(5):H1513-23. doi: 10.1152/ajpheart.00485.2008. Epub 2009 Mar 13.

18.

Tumor necrosis factor-alpha mediates cardiac remodeling and ventricular dysfunction after pressure overload state.

Sun M, Chen M, Dawood F, Zurawska U, Li JY, Parker T, Kassiri Z, Kirshenbaum LA, Arnold M, Khokha R, Liu PP.

Circulation. 2007 Mar 20;115(11):1398-407. Epub 2007 Mar 12.

19.

Loss of PI3Kγ enhances cAMP-dependent MMP remodeling of the myocardial N-cadherin adhesion complexes and extracellular matrix in response to early biomechanical stress.

Guo D, Kassiri Z, Basu R, Chow FL, Kandalam V, Damilano F, Liang W, Izumo S, Hirsch E, Penninger JM, Backx PH, Oudit GY.

Circ Res. 2010 Nov 12;107(10):1275-89. doi: 10.1161/CIRCRESAHA.110.229054. Epub 2010 Sep 16.

20.

Diacylglycerol kinase zeta rescues G alpha q-induced heart failure in transgenic mice.

Niizeki T, Takeishi Y, Kitahara T, Arimoto T, Koyama Y, Goto K, Mende U, Kubota I.

Circ J. 2008 Feb;72(2):309-17.

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