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Regulator of G protein signaling 2 is a key modulator of airway hyperresponsiveness.

Xie Y, Jiang H, Nguyen H, Jia S, Berro A, Panettieri RA Jr, Wolff DW, Abel PW, Casale TB, Tu Y.

J Allergy Clin Immunol. 2012 Oct;130(4):968-76.e3. doi: 10.1016/j.jaci.2012.05.004. Epub 2012 Jun 15.


Loss of regulator of G protein signaling 5 promotes airway hyperresponsiveness in the absence of allergic inflammation.

Balenga NA, Jester W, Jiang M, Panettieri RA Jr, Druey KM.

J Allergy Clin Immunol. 2014 Aug;134(2):451-9. doi: 10.1016/j.jaci.2014.01.019. Epub 2014 Mar 22.


Targeting phosphoinositide 3-kinase γ in airway smooth muscle cells to suppress interleukin-13-induced mouse airway hyperresponsiveness.

Jiang H, Xie Y, Abel PW, Toews ML, Townley RG, Casale TB, Tu Y.

J Pharmacol Exp Ther. 2012 Aug;342(2):305-11. doi: 10.1124/jpet.111.189704. Epub 2012 Apr 27.


Regulator of G-protein signaling 2 repression exacerbates airway hyper-responsiveness and remodeling in asthma.

Jiang H, Xie Y, Abel PW, Wolff DW, Toews ML, Panettieri RA Jr, Casale TB, Tu Y.

Am J Respir Cell Mol Biol. 2015 Jul;53(1):42-9. doi: 10.1165/rcmb.2014-0319OC.


The transmembrane protein 16A Ca(2+)-activated Cl- channel in airway smooth muscle contributes to airway hyperresponsiveness.

Zhang CH, Li Y, Zhao W, Lifshitz LM, Li H, Harfe BD, Zhu MS, ZhuGe R.

Am J Respir Crit Care Med. 2013 Feb 15;187(4):374-81. doi: 10.1164/rccm.201207-1303OC. Epub 2012 Dec 13.


Role of Abl in airway hyperresponsiveness and airway remodeling.

Cleary RA, Wang R, Wang T, Tang DD.

Respir Res. 2013 Oct 11;14:105. doi: 10.1186/1465-9921-14-105.


Enhanced proliferation and altered calcium handling in RGS2-deficient vascular smooth muscle cells.

Momen A, Afroze T, Sadi AM, Khoshbin A, Zhang H, Choi J, Gu S, Zaidi SH, Heximer SP, Husain M.

J Recept Signal Transduct Res. 2014 Dec;34(6):476-83. doi: 10.3109/10799893.2014.920393. Epub 2014 May 20.


CD151, a laminin receptor showing increased expression in asthmatic patients, contributes to airway hyperresponsiveness through calcium signaling.

Qiao Y, Tam JKC, Tan SSL, Tai YK, Chin CY, Stewart AG, Ashman L, Sekiguchi K, Langenbach SY, Stelmack G, Halayko AJ, Tran T; Melbourne Epidemiological Study of Childhood Asthma group.

J Allergy Clin Immunol. 2017 Jan;139(1):82-92.e5. doi: 10.1016/j.jaci.2016.03.029. Epub 2016 Apr 27.


Osteopontin deficiency protects against airway remodeling and hyperresponsiveness in chronic asthma.

Simoes DC, Xanthou G, Petrochilou K, Panoutsakopoulou V, Roussos C, Gratziou C.

Am J Respir Crit Care Med. 2009 May 15;179(10):894-902. doi: 10.1164/rccm.200807-1081OC. Epub 2009 Feb 20.


Role of regulator of G protein signaling 2 (RGS2) in Ca(2+) oscillations and adaptation of Ca(2+) signaling to reduce excitability of RGS2-/- cells.

Wang X, Huang G, Luo X, Penninger JM, Muallem S.

J Biol Chem. 2004 Oct 1;279(40):41642-9. Epub 2004 Aug 2.


Reduced expression of regulator of G-protein signaling 2 (RGS2) in hypertensive patients increases calcium mobilization and ERK1/2 phosphorylation induced by angiotensin II.

Semplicini A, Lenzini L, Sartori M, Papparella I, Calò LA, Pagnin E, Strapazzon G, Benna C, Costa R, Avogaro A, Ceolotto G, Pessina AC.

J Hypertens. 2006 Jun;24(6):1115-24.


Laminin drives survival signals to promote a contractile smooth muscle phenotype and airway hyperreactivity.

Tran T, Teoh CM, Tam JK, Qiao Y, Chin CY, Chong OK, Stewart AG, Harris T, Wong WS, Guan SP, Leung BP, Gerthoffer WT, Unruh H, Halayko AJ.

FASEB J. 2013 Oct;27(10):3991-4003. doi: 10.1096/fj.12-221341. Epub 2013 Jun 11.


An RGS4-mediated phenotypic switch of bronchial smooth muscle cells promotes fixed airway obstruction in asthma.

Damera G, Druey KM, Cooper PR, Krymskaya VP, Soberman RJ, Amrani Y, Hoshi T, Brightling CE, Panettieri RA Jr.

PLoS One. 2012;7(1):e28504. doi: 10.1371/journal.pone.0028504. Epub 2012 Jan 12.


IL-33 drives airway hyper-responsiveness through IL-13-mediated mast cell: airway smooth muscle crosstalk.

Kaur D, Gomez E, Doe C, Berair R, Woodman L, Saunders R, Hollins F, Rose FR, Amrani Y, May R, Kearley J, Humbles A, Cohen ES, Brightling CE.

Allergy. 2015 May;70(5):556-67. doi: 10.1111/all.12593. Epub 2015 Mar 16.


RGS4 Overexpression in Lung Attenuates Airway Hyperresponsiveness in Mice.

Madigan LA, Wong GS, Gordon EM, Chen WS, Balenga N, Koziol-White CJ, Panettieri RA Jr, Levine SJ, Druey KM.

Am J Respir Cell Mol Biol. 2018 Jan;58(1):89-98. doi: 10.1165/rcmb.2017-0109OC.


Sites of allergic airway smooth muscle remodeling and hyperresponsiveness are not associated in the rat.

Siddiqui S, Jo T, Tamaoka M, Shalaby KH, Ghezzo H, Bernabeu M, Martin JG.

J Appl Physiol (1985). 2010 Oct;109(4):1170-8. doi: 10.1152/japplphysiol.01168.2009. Epub 2010 Jul 22.


β2-Adrenoceptor agonist-induced RGS2 expression is a genomic mechanism of bronchoprotection that is enhanced by glucocorticoids.

Holden NS, Bell MJ, Rider CF, King EM, Gaunt DD, Leigh R, Johnson M, Siderovski DP, Heximer SP, Giembycz MA, Newton R.

Proc Natl Acad Sci U S A. 2011 Dec 6;108(49):19713-8. doi: 10.1073/pnas.1110226108. Epub 2011 Nov 11.


Rho-kinase and contractile apparatus proteins in murine airway hyperresponsiveness.

Witzenrath M, Ahrens B, Schmeck B, Kube SM, Hippenstiel S, Rosseau S, Hamelmann E, Suttorp N, Schütte H.

Exp Toxicol Pathol. 2008 Jun;60(1):9-15. doi: 10.1016/j.etp.2008.03.002. Epub 2008 Apr 22.


Protective Roles for RGS2 in a Mouse Model of House Dust Mite-Induced Airway Inflammation.

George T, Bell M, Chakraborty M, Siderovski DP, Giembycz MA, Newton R.

PLoS One. 2017 Jan 20;12(1):e0170269. doi: 10.1371/journal.pone.0170269. eCollection 2017.


[Molecular mechanisms of the hyperresponsiveness of airway smooth muscle in bronchial asthma].

Chiba Y, Misawa M.

Nihon Yakurigaku Zasshi. 1998 Apr;111(4):249-56. Review. Japanese.


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