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Items: 1 to 20 of 121

1.

Stem cell-derived hepatocytes as a predictive model for drug-induced liver injury: are we there yet?

Kia R, Sison RL, Heslop J, Kitteringham NR, Hanley N, Mills JS, Park BK, Goldring CE.

Br J Clin Pharmacol. 2013 Apr;75(4):885-96. doi: 10.1111/j.1365-2125.2012.04360.x. Review.

2.

Human hepatocytes derived from pluripotent stem cells: a promising cell model for drug hepatotoxicity screening.

Gómez-Lechón MJ, Tolosa L.

Arch Toxicol. 2016 Sep;90(9):2049-61. doi: 10.1007/s00204-016-1756-1. Review.

PMID:
27325232
3.

Hepatic differentiation and maturation of human embryonic stem cells cultured in a perfused three-dimensional bioreactor.

Sivertsson L, Synnergren J, Jensen J, Björquist P, Ingelman-Sundberg M.

Stem Cells Dev. 2013 Feb 15;22(4):581-94. doi: 10.1089/scd.2012.0202.

4.

Accurate prediction of drug-induced liver injury using stem cell-derived populations.

Szkolnicka D, Farnworth SL, Lucendo-Villarin B, Storck C, Zhou W, Iredale JP, Flint O, Hay DC.

Stem Cells Transl Med. 2014 Feb;3(2):141-8. doi: 10.5966/sctm.2013-0146.

5.

MicroRNA-122: a novel hepatocyte-enriched in vitro marker of drug-induced cellular toxicity.

Kia R, Kelly L, Sison-Young RL, Zhang F, Pridgeon CS, Heslop JA, Metcalfe P, Kitteringham NR, Baxter M, Harrison S, Hanley NA, Burke ZD, Storm MP, Welham MJ, Tosh D, Küppers-Munther B, Edsbagge J, Starkey Lewis PJ, Bonner F, Harpur E, Sidaway J, Bowes J, Fenwick SW, Malik H, Goldring CE, Park BK.

Toxicol Sci. 2015 Mar;144(1):173-85. doi: 10.1093/toxsci/kfu269.

6.

Transplantation of hESC-derived hepatocytes protects mice from liver injury.

Tolosa L, Caron J, Hannoun Z, Antoni M, López S, Burks D, Castell JV, Weber A, Gomez-Lechon MJ, Dubart-Kupperschmitt A.

Stem Cell Res Ther. 2015 Dec 12;6:246. doi: 10.1186/s13287-015-0227-6.

7.

Pluripotent stem cell derived hepatocyte like cells and their potential in toxicity screening.

Greenhough S, Medine CN, Hay DC.

Toxicology. 2010 Dec 30;278(3):250-5. doi: 10.1016/j.tox.2010.07.012. Review.

PMID:
20674645
8.

Generation of functional hepatocytes from human embryonic stem cells under chemically defined conditions that recapitulate liver development.

Touboul T, Hannan NR, Corbineau S, Martinez A, Martinet C, Branchereau S, Mainot S, Strick-Marchand H, Pedersen R, Di Santo J, Weber A, Vallier L.

Hepatology. 2010 May;51(5):1754-65. doi: 10.1002/hep.23506. Erratum in: Hepatology. 2010 Jul;52(1):402.

PMID:
20301097
9.

Developing high-fidelity hepatotoxicity models from pluripotent stem cells.

Medine CN, Lucendo-Villarin B, Storck C, Wang F, Szkolnicka D, Khan F, Pernagallo S, Black JR, Marriage HM, Ross JA, Bradley M, Iredale JP, Flint O, Hay DC.

Stem Cells Transl Med. 2013 Jul;2(7):505-9. doi: 10.5966/sctm.2012-0138.

10.

Differentiation of hepatocytes from pluripotent stem cells.

Mallanna SK, Duncan SA.

Curr Protoc Stem Cell Biol. 2013 Sep 20;26:Unit 1G.4.. doi: 10.1002/9780470151808.sc01g04s26.

11.

Toward preclinical predictive drug testing for metabolism and hepatotoxicity by using in vitro models derived from human embryonic stem cells and human cell lines - a report on the Vitrocellomics EU-project.

Mandenius CF, Andersson TB, Alves PM, Batzl-Hartmann C, Björquist P, Carrondo MJ, Chesne C, Coecke S, Edsbagge J, Fredriksson JM, Gerlach JC, Heinzle E, Ingelman-Sundberg M, Johansson I, Küppers-Munther B, Müller-Vieira U, Noor F, Zeilinger K.

Altern Lab Anim. 2011 May;39(2):147-71.

12.

High-content assays for hepatotoxicity using induced pluripotent stem cell-derived cells.

Sirenko O, Hesley J, Rusyn I, Cromwell EF.

Assay Drug Dev Technol. 2014 Jan-Feb;12(1):43-54. doi: 10.1089/adt.2013.520.

13.

Aggregate culture of human embryonic stem cell-derived hepatocytes in suspension are an improved in vitro model for drug metabolism and toxicity testing.

Sengupta S, Johnson BP, Swanson SA, Stewart R, Bradfield CA, Thomson JA.

Toxicol Sci. 2014 Jul;140(1):236-45. doi: 10.1093/toxsci/kfu069.

14.

Robust generation of hepatocyte-like cells from human embryonic stem cell populations.

Medine CN, Lucendo-Villarin B, Zhou W, West CC, Hay DC.

J Vis Exp. 2011 Oct 26;(56):e2969. doi: 10.3791/2969.

15.

Cost-effective differentiation of hepatocyte-like cells from human pluripotent stem cells using small molecules.

Tasnim F, Phan D, Toh YC, Yu H.

Biomaterials. 2015 Nov;70:115-25. doi: 10.1016/j.biomaterials.2015.08.002.

PMID:
26310107
16.

Generation of functional hepatocyte-like cells from human pluripotent stem cells in a scalable suspension culture.

Vosough M, Omidinia E, Kadivar M, Shokrgozar MA, Pournasr B, Aghdami N, Baharvand H.

Stem Cells Dev. 2013 Oct 15;22(20):2693-705. doi: 10.1089/scd.2013.0088.

PMID:
23731381
17.

Rapid generation of mature hepatocyte-like cells from human induced pluripotent stem cells by an efficient three-step protocol.

Chen YF, Tseng CY, Wang HW, Kuo HC, Yang VW, Lee OK.

Hepatology. 2012 Apr;55(4):1193-203. doi: 10.1002/hep.24790.

18.

Feeder-free and serum-free production of hepatocytes, cholangiocytes, and their proliferating progenitors from human pluripotent stem cells: application to liver-specific functional and cytotoxic assays.

Nakamura N, Saeki K, Mitsumoto M, Matsuyama S, Nishio M, Saeki K, Hasegawa M, Miyagawa Y, Ohkita H, Kiyokawa N, Toyoda M, Akutsu H, Umezawa A, Yuo A.

Cell Reprogram. 2012 Apr;14(2):171-85. doi: 10.1089/cell.2011.0064.

PMID:
22384928
19.

Human pluripotent stem cells for modeling toxicity.

Sison-Young RL, Kia R, Heslop J, Kelly L, Rowe C, Cross MJ, Kitteringham NR, Hanley N, Park BK, Goldring CE.

Adv Pharmacol. 2012;63:207-56. doi: 10.1016/B978-0-12-398339-8.00006-9. Review.

PMID:
22776643
20.

[Robust differentiation of fetal hepatocytes from human embryonic stem cells and iPS].

Touboul T, Vallier L, Weber A.

Med Sci (Paris). 2010 Dec;26(12):1061-6. doi: 10.1051/medsci/201026121061. Review. French.

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