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Items: 1 to 20 of 169

1.

Haptoglobin binding stabilizes hemoglobin ferryl iron and the globin radical on tyrosine β145.

Cooper CE, Schaer DJ, Buehler PW, Wilson MT, Reeder BJ, Silkstone G, Svistunenko DA, Bulow L, Alayash AI.

Antioxid Redox Signal. 2013 Jun 10;18(17):2264-73. doi: 10.1089/ars.2012.4547.

2.

Spin trapping combined with quantitative mass spectrometry defines free radical redistribution within the oxidized hemoglobin:haptoglobin complex.

Vallelian F, Garcia-Rubio I, Puglia M, Kahraman A, Deuel JW, Engelsberger WR, Mason RP, Buehler PW, Schaer DJ.

Free Radic Biol Med. 2015 Aug;85:259-68. doi: 10.1016/j.freeradbiomed.2015.04.023.

PMID:
25933590
3.

Haptoglobin alters oxygenation and oxidation of hemoglobin and decreases propagation of peroxide-induced oxidative reactions.

Banerjee S, Jia Y, Siburt CJ, Abraham B, Wood F, Bonaventura C, Henkens R, Crumbliss AL, Alayash AI.

Free Radic Biol Med. 2012 Sep 15;53(6):1317-26. doi: 10.1016/j.freeradbiomed.2012.07.023.

PMID:
22841869
4.

Redox properties of human hemoglobin in complex with fractionated dimeric and polymeric human haptoglobin.

Mollan TL, Jia Y, Banerjee S, Wu G, Kreulen RT, Tsai AL, Olson JS, Crumbliss AL, Alayash AI.

Free Radic Biol Med. 2014 Apr;69:265-77. doi: 10.1016/j.freeradbiomed.2014.01.030.

5.

Quantitative mass spectrometry defines an oxidative hotspot in hemoglobin that is specifically protected by haptoglobin.

Pimenova T, Pereira CP, Gehrig P, Buehler PW, Schaer DJ, Zenobi R.

J Proteome Res. 2010 Aug 6;9(8):4061-70. doi: 10.1021/pr100252e.

PMID:
20568812
6.

Tyrosine can protect against oxidative stress through ferryl hemoglobin reduction.

Lu N, He Y, Chen C, Tian R, Xiao Q, Peng YY.

Toxicol In Vitro. 2014 Aug;28(5):847-55. doi: 10.1016/j.tiv.2014.03.014.

PMID:
24698734
7.

Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification.

Buehler PW, Abraham B, Vallelian F, Linnemayr C, Pereira CP, Cipollo JF, Jia Y, Mikolajczyk M, Boretti FS, Schoedon G, Alayash AI, Schaer DJ.

Blood. 2009 Mar 12;113(11):2578-86. doi: 10.1182/blood-2008-08-174466.

8.
9.

Molecular modeling of the human hemoglobin-haptoglobin complex sheds light on the protective mechanisms of haptoglobin.

Nantasenamat C, Prachayasittikul V, Bulow L.

PLoS One. 2013 Apr 26;8(4):e62996. doi: 10.1371/journal.pone.0062996.

10.

Atherogenesis may involve the prooxidant and proinflammatory effects of ferryl hemoglobin.

Potor L, Bányai E, Becs G, Soares MP, Balla G, Balla J, Jeney V.

Oxid Med Cell Longev. 2013;2013:676425. doi: 10.1155/2013/676425.

11.

Tyrosine residues as redox cofactors in human hemoglobin: implications for engineering nontoxic blood substitutes.

Reeder BJ, Grey M, Silaghi-Dumitrescu RL, Svistunenko DA, Bülow L, Cooper CE, Wilson MT.

J Biol Chem. 2008 Nov 7;283(45):30780-7. doi: 10.1074/jbc.M804709200.

12.

The reaction of hydrogen peroxide with hemoglobin induces extensive alpha-globin crosslinking and impairs the interaction of hemoglobin with endogenous scavenger pathways.

Vallelian F, Pimenova T, Pereira CP, Abraham B, Mikolajczyk MG, Schoedon G, Zenobi R, Alayash AI, Buehler PW, Schaer DJ.

Free Radic Biol Med. 2008 Oct 15;45(8):1150-8. doi: 10.1016/j.freeradbiomed.2008.07.013.

PMID:
18708138
13.

Enhanced nitrite reductase activity associated with the haptoglobin complexed hemoglobin dimer: functional and antioxidative implications.

Roche CJ, Dantsker D, Alayash AI, Friedman JM.

Nitric Oxide. 2012 Jun 30;27(1):32-9. doi: 10.1016/j.niox.2012.04.002.

14.

Control of oxidative reactions of hemoglobin in the design of blood substitutes: role of the ascorbate-glutathione antioxidant system.

Simoni J, Villanueva-Meyer J, Simoni G, Moeller JF, Wesson DE.

Artif Organs. 2009 Feb;33(2):115-26. doi: 10.1111/j.1525-1594.2008.00695.x.

PMID:
19178455
15.
16.

Human Hp1-1 and Hp2-2 phenotype-specific haptoglobin therapeutics are both effective in vitro and in guinea pigs to attenuate hemoglobin toxicity.

Lipiski M, Deuel JW, Baek JH, Engelsberger WR, Buehler PW, Schaer DJ.

Antioxid Redox Signal. 2013 Nov 10;19(14):1619-33. doi: 10.1089/ars.2012.5089.

17.

Redox cycling of human methaemoglobin by H2O2 yields persistent ferryl iron and protein based radicals.

Patel RP, Svistunenko DA, Darley-Usmar VM, Symons MC, Wilson MT.

Free Radic Res. 1996 Aug;25(2):117-23.

PMID:
8885329
18.

Interactions of Haptoglobin with Monomeric Globin Species: Insights from Molecular Modeling and Native Electrospray Ionization Mass Spectrometry.

Fatunmbi O, Abzalimov RR, Savinov SN, Gershenson A, Kaltashov IA.

Biochemistry. 2016 Mar 29;55(12):1918-28. doi: 10.1021/acs.biochem.5b00807.

PMID:
26937685
19.

Nitrite attenuated hypochlorous acid-mediated heme degradation in hemoglobin.

Lu N, Li J, Ren X, Tian R, Peng YY.

Chem Biol Interact. 2015 Aug 5;238:25-32. doi: 10.1016/j.cbi.2015.05.021.

PMID:
26051522
20.

Melatonin attenuates hypochlorous acid-mediated heme destruction, free iron release, and protein aggregation in hemoglobin.

Maitra D, Abdulhamid I, Diamond MP, Saed GM, Abu-Soud HM.

J Pineal Res. 2012 Sep;53(2):198-205. doi: 10.1111/j.1600-079X.2012.00988.x.

PMID:
22462755
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