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Items: 1 to 20 of 98

1.

The ect2 rho Guanine nucleotide exchange factor is essential for early mouse development and normal cell cytokinesis and migration.

Cook DR, Solski PA, Bultman SJ, Kauselmann G, Schoor M, Kuehn R, Friedman LS, Cowley DO, Van Dyke T, Yeh JJ, Johnson L, Der CJ.

Genes Cancer. 2011 Oct;2(10):932-42. doi: 10.1177/1947601912437035.

2.

Human ECT2 is an exchange factor for Rho GTPases, phosphorylated in G2/M phases, and involved in cytokinesis.

Tatsumoto T, Xie X, Blumenthal R, Okamoto I, Miki T.

J Cell Biol. 1999 Nov 29;147(5):921-8.

3.

Rho exchange factor ECT2 is induced by growth factors and regulates cytokinesis through the N-terminal cell cycle regulator-related domains.

Saito S, Tatsumoto T, Lorenzi MV, Chedid M, Kapoor V, Sakata H, Rubin J, Miki T.

J Cell Biochem. 2003 Nov 1;90(4):819-36.

PMID:
14587037
4.

Requirement for C-terminal sequences in regulation of Ect2 guanine nucleotide exchange specificity and transformation.

Solski PA, Wilder RS, Rossman KL, Sondek J, Cox AD, Campbell SL, Der CJ.

J Biol Chem. 2004 Jun 11;279(24):25226-33. Epub 2004 Apr 8.

5.

The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis.

Kim JE, Billadeau DD, Chen J.

J Biol Chem. 2005 Feb 18;280(7):5733-9. Epub 2004 Nov 15.

6.
7.

Opposing roles of p190RhoGAP and Ect2 RhoGEF in regulating cytokinesis.

Mikawa M, Su L, Parsons SJ.

Cell Cycle. 2008 Jul 1;7(13):2003-12.

8.

Deregulation and mislocalization of the cytokinesis regulator ECT2 activate the Rho signaling pathways leading to malignant transformation.

Saito S, Liu XF, Kamijo K, Raziuddin R, Tatsumoto T, Okamoto I, Chen X, Lee CC, Lorenzi MV, Ohara N, Miki T.

J Biol Chem. 2004 Feb 20;279(8):7169-79. Epub 2003 Nov 25.

9.

Ect2 links the PKCiota-Par6alpha complex to Rac1 activation and cellular transformation.

Justilien V, Fields AP.

Oncogene. 2009 Oct 15;28(41):3597-607. doi: 10.1038/onc.2009.217. Epub 2009 Jul 20.

10.

The Role of Ect2 Nuclear RhoGEF Activity in Ovarian Cancer Cell Transformation.

Huff LP, Decristo MJ, Trembath D, Kuan PF, Yim M, Liu J, Cook DR, Miller CR, Der CJ, Cox AD.

Genes Cancer. 2013 Nov;4(11-12):460-75. doi: 10.1177/1947601913514851.

11.

Targeting of the RhoGEF Ect2 to the equatorial membrane controls cleavage furrow formation during cytokinesis.

Su KC, Takaki T, Petronczki M.

Dev Cell. 2011 Dec 13;21(6):1104-15. doi: 10.1016/j.devcel.2011.11.003.

12.

Expression of a Rho guanine nucleotide exchange factor, Ect2, in the developing mouse pituitary.

Islam MS, Tsuji T, Higashida C, Takahashi M, Higashida H, Koizumi K.

J Neuroendocrinol. 2010 May;22(5):477-82. doi: 10.1111/j.1365-2826.2010.01962.x. Epub 2010 Feb 5.

PMID:
20141573
13.

APC(cdh1) mediates degradation of the oncogenic Rho-GEF Ect2 after mitosis.

Liot C, Seguin L, Siret A, Crouin C, Schmidt S, Bertoglio J.

PLoS One. 2011;6(8):e23676. doi: 10.1371/journal.pone.0023676. Epub 2011 Aug 19.

14.

Leukemia-associated Rho guanine nucleotide exchange factor, a Dbl family protein found mutated in leukemia, causes transformation by activation of RhoA.

Reuther GW, Lambert QT, Booden MA, Wennerberg K, Becknell B, Marcucci G, Sondek J, Caligiuri MA, Der CJ.

J Biol Chem. 2001 Jul 20;276(29):27145-51. Epub 2001 May 23.

15.

Influence of human Ect2 depletion and overexpression on cleavage furrow formation and abscission.

Chalamalasetty RB, Hümmer S, Nigg EA, Silljé HH.

J Cell Sci. 2006 Jul 15;119(Pt 14):3008-19. Epub 2006 Jun 27.

16.

An anillin-Ect2 complex stabilizes central spindle microtubules at the cortex during cytokinesis.

Frenette P, Haines E, Loloyan M, Kinal M, Pakarian P, Piekny A.

PLoS One. 2012;7(4):e34888. doi: 10.1371/journal.pone.0034888. Epub 2012 Apr 13.

17.

Rho guanine nucleotide exchange factors: regulators of Rho GTPase activity in development and disease.

Cook DR, Rossman KL, Der CJ.

Oncogene. 2014 Jul 31;33(31):4021-35. doi: 10.1038/onc.2013.362. Epub 2013 Sep 16. Review.

18.

ECT2 and RASAL2 mediate mesenchymal-amoeboid transition in human astrocytoma cells.

Weeks A, Okolowsky N, Golbourn B, Ivanchuk S, Smith C, Rutka JT.

Am J Pathol. 2012 Aug;181(2):662-74. doi: 10.1016/j.ajpath.2012.04.011. Epub 2012 Jun 7.

PMID:
22683310
19.

Potential roles of the nucleotide exchange factor ECT2 and Cdc42 GTPase in spindle assembly in Xenopus egg cell-free extracts.

Tatsumoto T, Sakata H, Dasso M, Miki T.

J Cell Biochem. 2003 Dec 1;90(5):892-900.

PMID:
14624449
20.

Oncogenic Ect2 signaling regulates rRNA synthesis in NSCLC.

Justilien V, Lewis KC, Murray NR, Fields AP.

Small GTPases. 2017 Jun 28:1-7. doi: 10.1080/21541248.2017.1335274. [Epub ahead of print]

PMID:
28657426

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