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Items: 1 to 20 of 171

1.

Increased hepatic fibrosis and JNK2-dependent liver injury in mice exhibiting hepatocyte-specific deletion of cFLIP.

Schattenberg JM, Nagel M, Kim YO, Kohl T, Wörns MA, Zimmermann T, Schad A, Longerich T, Schuppan D, He YW, Galle PR, Schuchmann M.

Am J Physiol Gastrointest Liver Physiol. 2012 Aug 15;303(4):G498-506. doi: 10.1152/ajpgi.00525.2011. Epub 2012 Jun 14.

2.

Diabetic liver injury from streptozotocin is regulated through the caspase-8 homolog cFLIP involving activation of JNK2 and intrahepatic immunocompetent cells.

Kohl T, Gehrke N, Schad A, Nagel M, Wörns MA, Sprinzl MF, Zimmermann T, He YW, Galle PR, Schuchmann M, Schattenberg JM.

Cell Death Dis. 2013 Jul 4;4:e712. doi: 10.1038/cddis.2013.228.

3.

Combined Activities of JNK1 and JNK2 in Hepatocytes Protect Against Toxic Liver Injury.

Cubero FJ, Zoubek ME, Hu W, Peng J, Zhao G, Nevzorova YA, Al Masaoudi M, Bechmann LP, Boekschoten MV, Muller M, Preisinger C, Gassler N, Canbay AE, Luedde T, Davis RJ, Liedtke C, Trautwein C.

Gastroenterology. 2016 Apr;150(4):968-81. doi: 10.1053/j.gastro.2015.12.019. Epub 2015 Dec 19.

4.

Ablation of c-FLIP in hepatocytes enhances death-receptor mediated apoptosis and toxic liver injury in vivo.

Schattenberg JM, Zimmermann T, Wörns M, Sprinzl MF, Kreft A, Kohl T, Nagel M, Siebler J, Schulze Bergkamen H, He YW, Galle PR, Schuchmann M.

J Hepatol. 2011 Dec;55(6):1272-80. doi: 10.1016/j.jhep.2011.03.008. Epub 2011 Apr 15.

PMID:
21703207
5.

Liver fibrosis protects mice from acute hepatocellular injury.

Bourbonnais E, Raymond VA, Ethier C, Nguyen BN, El-Leil MS, Meloche S, Bilodeau M.

Gastroenterology. 2012 Jan;142(1):130-139.e4. doi: 10.1053/j.gastro.2011.09.033. Epub 2011 Sep 21.

PMID:
21945831
6.

Fibromodulin, an oxidative stress-sensitive proteoglycan, regulates the fibrogenic response to liver injury in mice.

Mormone E, Lu Y, Ge X, Fiel MI, Nieto N.

Gastroenterology. 2012 Mar;142(3):612-621.e5. doi: 10.1053/j.gastro.2011.11.029. Epub 2011 Dec 1.

7.

Caspase-12 mediates carbon tetrachloride-induced hepatocyte apoptosis in mice.

Liu H, Wang Z, Nowicki MJ.

World J Gastroenterol. 2014 Dec 28;20(48):18189-98. doi: 10.3748/wjg.v20.i48.18189.

8.

Recql5 protects against lipopolysaccharide/D-galactosamine-induced liver injury in mice.

Liao WQ, Qi YL, Wang L, Dong XM, Xu T, Ding CD, Liu R, Liang WC, Lu LT, Li H, Li WF, Luo GB, Lu XC.

World J Gastroenterol. 2015 Sep 28;21(36):10375-84. doi: 10.3748/wjg.v21.i36.10375.

9.

Hepatocyte-specific deletion of ARNT (aryl hydrocarbon Receptor Nuclear Translocator) results in altered fibrotic gene expression in the thioacetamide model of liver injury.

Scott C, Cha K, Rao R, Liddle C, George J, Gunton JE.

PLoS One. 2015 Mar 26;10(3):e0121650. doi: 10.1371/journal.pone.0121650. eCollection 2015.

10.

Tumor necrosis factor-induced toxic liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial death pathway.

Wang Y, Singh R, Lefkowitch JH, Rigoli RM, Czaja MJ.

J Biol Chem. 2006 Jun 2;281(22):15258-67. Epub 2006 Mar 29.

11.

Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis.

Kodama Y, Taura K, Miura K, Schnabl B, Osawa Y, Brenner DA.

Gastroenterology. 2009 Apr;136(4):1423-34. doi: 10.1053/j.gastro.2008.12.064. Epub 2009 Jan 6.

PMID:
19249395
12.

Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-Jun N-terminal kinase activation.

Nakagawa H, Maeda S, Hikiba Y, Ohmae T, Shibata W, Yanai A, Sakamoto K, Ogura K, Noguchi T, Karin M, Ichijo H, Omata M.

Gastroenterology. 2008 Oct;135(4):1311-21. doi: 10.1053/j.gastro.2008.07.006. Epub 2008 Jul 9.

PMID:
18700144
13.

The role of death effector domain-containing proteins in acute oxidative cell injury in hepatocytes.

Schattenberg JM, Wörns MA, Zimmermann T, He YW, Galle PR, Schuchmann M.

Free Radic Biol Med. 2012 May 1;52(9):1911-7. doi: 10.1016/j.freeradbiomed.2012.02.049. Epub 2012 Mar 8.

14.

Endoplasmic Reticulum Stress-induced Hepatocellular Death Pathways Mediate Liver Injury and Fibrosis via Stimulator of Interferon Genes.

Iracheta-Vellve A, Petrasek J, Gyongyosi B, Satishchandran A, Lowe P, Kodys K, Catalano D, Calenda CD, Kurt-Jones EA, Fitzgerald KA, Szabo G.

J Biol Chem. 2016 Dec 23;291(52):26794-26805. doi: 10.1074/jbc.M116.736991. Epub 2016 Nov 3.

15.

The role of CYP2A5 in liver injury and fibrosis: chemical-specific difference.

Hong F, Si C, Gao P, Cederbaum AI, Xiong H, Lu Y.

Naunyn Schmiedebergs Arch Pharmacol. 2016 Jan;389(1):33-43. doi: 10.1007/s00210-015-1172-8. Epub 2015 Sep 12.

16.
17.

CD1d-restricted natural killer T cells contribute to hepatic inflammation and fibrogenesis in mice.

Ishikawa S, Ikejima K, Yamagata H, Aoyama T, Kon K, Arai K, Takeda K, Watanabe S.

J Hepatol. 2011 Jun;54(6):1195-204. doi: 10.1016/j.jhep.2010.08.022. Epub 2010 Nov 5.

PMID:
21145835
18.

Targeting ribosomal S-6 kinase for the prevention and treatment of liver injury and liver fibrosis.

Buck M.

Drug News Perspect. 2008 Jul-Aug;21(6):301-6. doi: 10.1358/dnp.2008.21.6.1246796. Review.

PMID:
18836586
19.

Epithelial Transforming Growth Factor-β Signaling Does Not Contribute to Liver Fibrosis but Protects Mice From Cholangiocarcinoma.

Mu X, Pradere JP, Affò S, Dapito DH, Friedman R, Lefkovitch JH, Schwabe RF.

Gastroenterology. 2016 Mar;150(3):720-33. doi: 10.1053/j.gastro.2015.11.039. Epub 2015 Nov 26.

PMID:
26627606
20.

A role for cFLIP in B cell proliferation and stress MAPK regulation.

Zhang H, Rosenberg S, Coffey FJ, He YW, Manser T, Hardy RR, Zhang J.

J Immunol. 2009 Jan 1;182(1):207-15.

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