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Items: 1 to 20 of 49

1.

Enhanced oxidative stress and endocrine pancreas alterations are linked to a novel glucokinase missense mutation in ENU-derived Munich Gck(D217V) mutants.

van Buerck L, Schuster M, Rathkolb B, Sabrautzki S, Hrabě de Angelis M, Wolf E, Aigner B, Wanke R, Herbach N.

Mol Cell Endocrinol. 2012 Oct 15;362(1-2):139-48. doi: 10.1016/j.mce.2012.06.001. Epub 2012 Jun 12.

PMID:
22698525
2.

Phenotypic and pathomorphological characteristics of a novel mutant mouse model for maturity-onset diabetes of the young type 2 (MODY 2).

van Bürck L, Blutke A, Kautz S, Rathkolb B, Klaften M, Wagner S, Kemter E, Hrabé de Angelis M, Wolf E, Aigner B, Wanke R, Herbach N.

Am J Physiol Endocrinol Metab. 2010 Mar;298(3):E512-23. doi: 10.1152/ajpendo.00465.2009. Epub 2009 Dec 1.

3.

Heterogeneity in disease severity in a family with a novel G68V GCK activating mutation causing persistent hyperinsulinaemic hypoglycaemia of infancy.

Wabitsch M, Lahr G, Van de Bunt M, Marchant C, Lindner M, von Puttkamer J, Fenneberg A, Debatin KM, Klein R, Ellard S, Clark A, Gloyn AL.

Diabet Med. 2007 Dec;24(12):1393-9. Epub 2007 Nov 1.

PMID:
17976205
4.

Generation of N-ethyl-N-nitrosourea (ENU) diabetes models in mice demonstrates genotype-specific action of glucokinase activators.

Fenner D, Odili S, Hong HK, Kobayashi Y, Kohsaka A, Siepka SM, Vitaterna MH, Chen P, Zelent B, Grimsby J, Takahashi JS, Matschinsky FM, Bass J.

J Biol Chem. 2011 Nov 11;286(45):39560-72. doi: 10.1074/jbc.M111.269100. Epub 2011 Sep 15.

5.

A series of maturity onset diabetes of the young, type 2 (MODY2) mouse models generated by a large-scale ENU mutagenesis program.

Inoue M, Sakuraba Y, Motegi H, Kubota N, Toki H, Matsui J, Toyoda Y, Miwa I, Terauchi Y, Kadowaki T, Shigeyama Y, Kasuga M, Adachi T, Fujimoto N, Matsumoto R, Tsuchihashi K, Kagami T, Inoue A, Kaneda H, Ishijima J, Masuya H, Suzuki T, Wakana S, Gondo Y, Minowa O, Shiroishi T, Noda T.

Hum Mol Genet. 2004 Jun 1;13(11):1147-57. Epub 2004 Apr 21.

PMID:
15102714
7.

Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset diabetes of the young.

Gloyn AL, Odili S, Zelent D, Buettger C, Castleden HA, Steele AM, Stride A, Shiota C, Magnuson MA, Lorini R, d'Annunzio G, Stanley CA, Kwagh J, van Schaftingen E, Veiga-da-Cunha M, Barbetti F, Dunten P, Han Y, Grimsby J, Taub R, Ellard S, Hattersley AT, Matschinsky FM.

J Biol Chem. 2005 Apr 8;280(14):14105-13. Epub 2005 Jan 25.

8.

[Effects of severe hyperglycaemia in pregnancy and early overfeeding on islet development and insulin resistance].

Zeng CJ, Zhang L, Yang HX.

Zhonghua Fu Chan Ke Za Zhi. 2010 Sep;45(9):658-63. Chinese.

PMID:
21092544
11.

Dominant-negative effects of a novel mutated Ins2 allele causes early-onset diabetes and severe beta-cell loss in Munich Ins2C95S mutant mice.

Herbach N, Rathkolb B, Kemter E, Pichl L, Klaften M, de Angelis MH, Halban PA, Wolf E, Aigner B, Wanke R.

Diabetes. 2007 May;56(5):1268-76. Epub 2007 Feb 15.

12.

Four novel cases of permanent neonatal diabetes mellitus caused by homozygous mutations in the glucokinase gene.

Bennett K, James C, Mutair A, Al-Shaikh H, Sinani A, Hussain K.

Pediatr Diabetes. 2011 May;12(3 Pt 1):192-6. doi: 10.1111/j.1399-5448.2010.00683.x. Epub 2010 Sep 6.

PMID:
21518409
14.

Glucokinase and IRS-2 are required for compensatory beta cell hyperplasia in response to high-fat diet-induced insulin resistance.

Terauchi Y, Takamoto I, Kubota N, Matsui J, Suzuki R, Komeda K, Hara A, Toyoda Y, Miwa I, Aizawa S, Tsutsumi S, Tsubamoto Y, Hashimoto S, Eto K, Nakamura A, Noda M, Tobe K, Aburatani H, Nagai R, Kadowaki T.

J Clin Invest. 2007 Jan;117(1):246-57.

15.

Glucokinase mutations in young children with hyperglycemia.

Codner E, Deng L, Pérez-Bravo F, Román R, Lanzano P, Cassorla F, Chung WK.

Diabetes Metab Res Rev. 2006 Sep-Oct;22(5):348-55.

PMID:
16444761
16.

Insight into the biochemical characteristics of a novel glucokinase gene mutation.

Shen Y, Cai M, Liang H, Wang H, Weng J.

Hum Genet. 2011 Mar;129(3):231-8. doi: 10.1007/s00439-010-0914-4. Epub 2010 Nov 23.

PMID:
21104275
17.

The Tet-On system in transgenic mice: inhibition of the mouse pdx-1 gene activity by antisense RNA expression in pancreatic beta-cells.

Lottmann H, Vanselow J, Hessabi B, Walther R.

J Mol Med (Berl). 2001 Jun;79(5-6):321-8.

PMID:
11485027
18.

Analysis of upstream glucokinase promoter activity in transgenic mice and identification of glucokinase in rare neuroendocrine cells in the brain and gut.

Jetton TL, Liang Y, Pettepher CC, Zimmerman EC, Cox FG, Horvath K, Matschinsky FM, Magnuson MA.

J Biol Chem. 1994 Feb 4;269(5):3641-54.

19.

Effects of alternate RNA splicing on glucokinase isoform activities in the pancreatic islet, liver, and pituitary.

Liang Y, Jetton TL, Zimmerman EC, Najafi H, Matschinsky FM, Magnuson MA.

J Biol Chem. 1991 Apr 15;266(11):6999-7007.

20.

Permanent neonatal diabetes caused by a homozygous nonsense mutation in the glucokinase gene.

Rubio-Cabezas O, Díaz González F, Aragonés A, Argente J, Campos-Barros A.

Pediatr Diabetes. 2008 Jun;9(3 Pt 1):245-9. doi: 10.1111/j.1399-5448.2007.00361.x. Epub 2008 Feb 21.

PMID:
18298419

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