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Telomere-driven tetraploidization occurs in human cells undergoing crisis and promotes transformation of mouse cells.

Davoli T, de Lange T.

Cancer Cell. 2012 Jun 12;21(6):765-76. doi: 10.1016/j.ccr.2012.03.044.


Centrosome aberrations in human mammary epithelial cells driven by cooperative interactions between p16INK4a deficiency and telomere-dependent genotoxic stress.

Domínguez D, Feijoo P, Bernal A, Ercilla A, Agell N, Genescà A, Tusell L.

Oncotarget. 2015 Sep 29;6(29):28238-56. doi: 10.18632/oncotarget.4958.


The requirement of p53 for maintaining chromosomal stability during tetraploidization.

Ho CC, Hau PM, Marxer M, Poon RY.

Oncotarget. 2010 Nov;1(7):583-95.


Inactivation of p53 function in cultured human mammary epithelial cells turns the telomere-length dependent senescence barrier from agonescence into crisis.

Garbe JC, Holst CR, Bassett E, Tlsty T, Stampfer MR.

Cell Cycle. 2007 Aug 1;6(15):1927-36. Epub 2007 May 30.


Progressive telomere dysfunction causes cytokinesis failure and leads to the accumulation of polyploid cells.

Pampalona J, Frías C, Genescà A, Tusell L.

PLoS Genet. 2012;8(4):e1002679. doi: 10.1371/journal.pgen.1002679. Epub 2012 Apr 26.


Persistent telomere damage induces bypass of mitosis and tetraploidy.

Davoli T, Denchi EL, de Lange T.

Cell. 2010 Apr 2;141(1):81-93. doi: 10.1016/j.cell.2010.01.031.


Cell death during crisis is mediated by mitotic telomere deprotection.

Hayashi MT, Cesare AJ, Rivera T, Karlseder J.

Nature. 2015 Jun 25;522(7557):492-6. doi: 10.1038/nature14513.


Telomere Shortening in Hematological Malignancies with Tetraploidization-A Mechanism for Chromosomal Instability?

Kjeldsen E.

Cancers (Basel). 2017 Nov 30;9(12). pii: E165. doi: 10.3390/cancers9120165.


Multiple centrosomes arise from tetraploidy checkpoint failure and mitotic centrosome clusters in p53 and RB pocket protein-compromised cells.

Borel F, Lohez OD, Lacroix FB, Margolis RL.

Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9819-24. Epub 2002 Jul 15.


Cooperation between p53 and the telomere-protecting shelterin component Pot1a in endometrial carcinogenesis.

Akbay EA, Peña CG, Ruder D, Michel JA, Nakada Y, Pathak S, Multani AS, Chang S, Castrillon DH.

Oncogene. 2013 Apr 25;32(17):2211-9. doi: 10.1038/onc.2012.232. Epub 2012 Jun 11.


Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypes.

Fordyce CA, Patten KT, Fessenden TB, DeFilippis R, Hwang ES, Zhao J, Tlsty TD.

Breast Cancer Res. 2012 Dec 7;14(6):R155. doi: 10.1186/bcr3368.


The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence.

Aksoy O, Chicas A, Zeng T, Zhao Z, McCurrach M, Wang X, Lowe SW.

Genes Dev. 2012 Jul 15;26(14):1546-57. doi: 10.1101/gad.196238.112.


Eroded human telomeres are more prone to remain uncapped and to trigger a G2 checkpoint response.

Jullien L, Mestre M, Roux P, Gire V.

Nucleic Acids Res. 2013 Jan;41(2):900-11. doi: 10.1093/nar/gks1121. Epub 2012 Nov 27.


Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts.

Rogan EM, Bryan TM, Hukku B, Maclean K, Chang AC, Moy EL, Englezou A, Warneford SG, Dalla-Pozza L, Reddel RR.

Mol Cell Biol. 1995 Sep;15(9):4745-53.


Telomere-based proliferative lifespan barriers in Werner-syndrome fibroblasts involve both p53-dependent and p53-independent mechanisms.

Davis T, Singhrao SK, Wyllie FS, Haughton MF, Smith PJ, Wiltshire M, Wynford-Thomas D, Jones CJ, Faragher RG, Kipling D.

J Cell Sci. 2003 Apr 1;116(Pt 7):1349-57.


Effect of oncogene expression on telomerase activation and telomere length in human endothelial, fibroblast and prostate epithelial cells.

Burger AM, Fiebig HH, Kuettel MR, Lautenberger JA, Kung HF, Rhim JS.

Int J Oncol. 1998 Nov;13(5):1043-8.


Immunosurveillance against tetraploidization-induced colon tumorigenesis.

Boilève A, Senovilla L, Vitale I, Lissa D, Martins I, Métivier D, van den Brink S, Clevers H, Galluzzi L, Castedo M, Kroemer G.

Cell Cycle. 2013 Feb 1;12(3):473-9. doi: 10.4161/cc.23369. Epub 2013 Jan 16.


Distinct profiles of critically short telomeres are a key determinant of different chromosome aberrations in immortalized human cells: whole-genome evidence from multiple cell lines.

Deng W, Tsao SW, Guan XY, Lucas JN, Si HX, Leung CS, Mak P, Wang LD, Cheung AL.

Oncogene. 2004 Dec 2;23(56):9090-101.


Combined loss of INK4a and caveolin-1 synergistically enhances cell proliferation and oncogene-induced tumorigenesis: role of INK4a/CAV-1 in mammary epithelial cell hyperplasia.

Williams TM, Lee H, Cheung MW, Cohen AW, Razani B, Iyengar P, Scherer PE, Pestell RG, Lisanti MP.

J Biol Chem. 2004 Jun 4;279(23):24745-56. Epub 2004 Mar 25.

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