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Specific mitochondrial DNA mutation in mice regulates diabetes and lymphoma development.

Hashizume O, Shimizu A, Yokota M, Sugiyama A, Nakada K, Miyoshi H, Itami M, Ohira M, Nagase H, Takenaga K, Hayashi J.

Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10528-33. doi: 10.1073/pnas.1202367109. Epub 2012 Jun 11.


Mitochondrial DNA mutations in mutator mice confer respiration defects and B-cell lymphoma development.

Mito T, Kikkawa Y, Shimizu A, Hashizume O, Katada S, Imanishi H, Ota A, Kato Y, Nakada K, Hayashi J.

PLoS One. 2013;8(2):e55789. doi: 10.1371/journal.pone.0055789. Epub 2013 Feb 13.


Generation of trans-mitochondrial mito-mice by the introduction of a pathogenic G13997A mtDNA from highly metastatic lung carcinoma cells.

Yokota M, Shitara H, Hashizume O, Ishikawa K, Nakada K, Ishii R, Taya C, Takenaga K, Yonekawa H, Hayashi J.

FEBS Lett. 2010 Sep 24;584(18):3943-8. doi: 10.1016/j.febslet.2010.07.048. Epub 2010 Aug 3.


Administration of an antioxidant prevents lymphoma development in transmitochondrial mice overproducing reactive oxygen species.

Yamanashi H, Hashizume O, Yonekawa H, Nakada K, Hayashi J.

Exp Anim. 2014;63(4):459-66. Epub 2014 Jul 22.


Specific mtDNA mutations in mouse carcinoma cells suppress their tumor formation via activation of the host innate immune system.

Imanishi H, Takibuchi G, Kobayashi T, Ishikawa K, Nakada K, Mori M, Kikkawa Y, Takenaga K, Toyama-Sorimachi N, Hayashi J.

PLoS One. 2013 Sep 30;8(9):e75981. doi: 10.1371/journal.pone.0075981. eCollection 2013.


Transmitochondrial mice as models for primary prevention of diseases caused by mutation in the tRNA(Lys) gene.

Shimizu A, Mito T, Hayashi C, Ogasawara E, Koba R, Negishi I, Takenaga K, Nakada K, Hayashi J.

Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):3104-9. doi: 10.1073/pnas.1318109111. Epub 2014 Feb 7.


Somatic mtDNA mutations cause aging phenotypes without affecting reactive oxygen species production.

Trifunovic A, Hansson A, Wredenberg A, Rovio AT, Dufour E, Khvorostov I, Spelbrink JN, Wibom R, Jacobs HT, Larsson NG.

Proc Natl Acad Sci U S A. 2005 Dec 13;102(50):17993-8. Epub 2005 Dec 6.


A novel function of mtDNA: its involvement in metastasis.

Ishikawa K, Hayashi J.

Ann N Y Acad Sci. 2010 Jul;1201:40-3. doi: 10.1111/j.1749-6632.2010.05616.x. Review.


Animal models for mitochondrial disease.

Wallace DC.

Methods Mol Biol. 2002;197:3-54. Review.


Mitochondrial DNA mutations regulate metastasis of human breast cancer cells.

Imanishi H, Hattori K, Wada R, Ishikawa K, Fukuda S, Takenaga K, Nakada K, Hayashi J.

PLoS One. 2011;6(8):e23401. doi: 10.1371/journal.pone.0023401. Epub 2011 Aug 11.


Mutations in mitochondrial DNA regulate mitochondrial diseases and metastasis but do not regulate aging.

Hayashi JI, Hashizume O, Ishikawa K, Shimizu A.

Curr Opin Genet Dev. 2016 Jun;38:63-67. doi: 10.1016/j.gde.2016.03.004. Epub 2016 Apr 11. Review.


[Model mouse for mitochondrial DNA-based diseases].

Nakada K, Sato A, Hayashi J.

Rinsho Shinkeigaku. 2008 Nov;48(11):1013-5. Review. Japanese.


Enhanced glycolysis induced by mtDNA mutations does not regulate metastasis.

Ishikawa K, Hashizume O, Koshikawa N, Fukuda S, Nakada K, Takenaga K, Hayashi J.

FEBS Lett. 2008 Oct 15;582(23-24):3525-30. doi: 10.1016/j.febslet.2008.09.024. Epub 2008 Sep 19.


A specific nuclear DNA background is required for high frequency lymphoma development in transmitochondrial mice with G13997A mtDNA.

Hashizume O, Yamanashi H, Taketo MM, Nakada K, Hayashi J.

PLoS One. 2015 Mar 4;10(3):e0118561. doi: 10.1371/journal.pone.0118561. eCollection 2015.


Reversible regulation of metastasis by ROS-generating mtDNA mutations.

Ishikawa K, Koshikawa N, Takenaga K, Nakada K, Hayashi J.

Mitochondrion. 2008 Sep;8(4):339-44. doi: 10.1016/j.mito.2008.07.006. Epub 2008 Aug 8. Review.


Mouse models for mitochondrial disease.

Wallace DC.

Am J Med Genet. 2001 Spring;106(1):71-93. Review.


Selection of rodent species appropriate for mtDNA transfer to generate transmitochondrial mito-mice expressing mitochondrial respiration defects.

Enoki S, Shimizu A, Hayashi C, Imanishi H, Hashizume O, Mekada K, Suzuki H, Hashimoto T, Nakada K, Hayashi J.

Exp Anim. 2014;63(1):21-30.


Transmitochondrial mito-miceΔ and mtDNA mutator mice, but not aged mice, share the same spectrum of musculoskeletal disorders.

Mito T, Ishizaki H, Suzuki M, Morishima H, Ota A, Ishikawa K, Nakada K, Maeno A, Shiroishi T, Hayashi J.

Biochem Biophys Res Commun. 2015 Jan 24;456(4):933-7. doi: 10.1016/j.bbrc.2014.12.009. Epub 2014 Dec 12.


ROS-generating mitochondrial DNA mutations can regulate tumor cell metastasis.

Ishikawa K, Takenaga K, Akimoto M, Koshikawa N, Yamaguchi A, Imanishi H, Nakada K, Honma Y, Hayashi J.

Science. 2008 May 2;320(5876):661-4. doi: 10.1126/science.1156906. Epub 2008 Apr 3.


Reverse genetic studies of mitochondrial DNA-based diseases using a mouse model.

Nakada K, Sato A, Hayashi J.

Proc Jpn Acad Ser B Phys Biol Sci. 2008;84(5):155-65. Review.

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