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Items: 1 to 20 of 147

1.

Neuregulin 1-ErbB4-PI3K signaling in schizophrenia and phosphoinositide 3-kinase-p110δ inhibition as a potential therapeutic strategy.

Law AJ, Wang Y, Sei Y, O'Donnell P, Piantadosi P, Papaleo F, Straub RE, Huang W, Thomas CJ, Vakkalanka R, Besterman AD, Lipska BK, Hyde TM, Harrison PJ, Kleinman JE, Weinberger DR.

Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):12165-70. doi: 10.1073/pnas.1206118109. Epub 2012 Jun 11.

2.

Differential effects of short- and long-term antipsychotic treatment on the expression of neuregulin-1 and ErbB4 receptors in the rat brain.

Deng C, Pan B, Hu CH, Han M, Huang XF.

Psychiatry Res. 2015 Feb 28;225(3):347-54. doi: 10.1016/j.psychres.2014.12.014. Epub 2014 Dec 19.

PMID:
25576368
3.

Neuregulin-1 signalling and antipsychotic treatment: potential therapeutic targets in a schizophrenia candidate signalling pathway.

Deng C, Pan B, Engel M, Huang XF.

Psychopharmacology (Berl). 2013 Mar;226(2):201-15. doi: 10.1007/s00213-013-3003-2. Epub 2013 Feb 7. Review.

PMID:
23389757
4.

Finding a druggable target for schizophrenia.

Rico B.

Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):11902-3. doi: 10.1073/pnas.1209389109. Epub 2012 Jul 9. No abstract available.

5.

Disease-associated intronic variants in the ErbB4 gene are related to altered ErbB4 splice-variant expression in the brain in schizophrenia.

Law AJ, Kleinman JE, Weinberger DR, Weickert CS.

Hum Mol Genet. 2007 Jan 15;16(2):129-41. Epub 2006 Dec 12.

6.

Behavioral, Neurophysiological, and Synaptic Impairment in a Transgenic Neuregulin1 (NRG1-IV) Murine Schizophrenia Model.

Papaleo F, Yang F, Paterson C, Palumbo S, Carr GV, Wang Y, Floyd K, Huang W, Thomas CJ, Chen J, Weinberger DR, Law AJ.

J Neurosci. 2016 Apr 27;36(17):4859-75. doi: 10.1523/JNEUROSCI.4632-15.2016.

PMID:
27122041
7.

Schizophrenia susceptibility pathway neuregulin 1-ErbB4 suppresses Src upregulation of NMDA receptors.

Pitcher GM, Kalia LV, Ng D, Goodfellow NM, Yee KT, Lambe EK, Salter MW.

Nat Med. 2011 Apr;17(4):470-8. doi: 10.1038/nm.2315. Epub 2011 Mar 27.

8.

Molecular dissection of NRG1-ERBB4 signaling implicates PTPRZ1 as a potential schizophrenia susceptibility gene.

Buxbaum JD, Georgieva L, Young JJ, Plescia C, Kajiwara Y, Jiang Y, Moskvina V, Norton N, Peirce T, Williams H, Craddock NJ, Carroll L, Corfas G, Davis KL, Owen MJ, Harroch S, Sakurai T, O'Donovan MC.

Mol Psychiatry. 2008 Feb;13(2):162-72. Epub 2007 Apr 17.

PMID:
17579610
9.

TrkB interacts with ErbB4 and regulates NRG1-induced NR2B phosphorylation in cortical neurons before synaptogenesis.

Pandya CD, Pillai A.

Cell Commun Signal. 2014 Jul 24;12:47. doi: 10.1186/s12964-014-0047-9.

10.

Increased expression of the PI3K catalytic subunit p110δ underlies elevated S6 phosphorylation and protein synthesis in an individual with autism from a multiplex family.

Poopal AC, Schroeder LM, Horn PS, Bassell GJ, Gross C.

Mol Autism. 2016 Jan 14;7:3. doi: 10.1186/s13229-015-0066-4. eCollection 2016.

11.

ErbB4 expression in neural progenitor cells (ST14A) is necessary to mediate neuregulin-1beta1-induced migration.

Gambarotta G, Garzotto D, Destro E, Mautino B, Giampietro C, Cutrupi S, Dati C, Cattaneo E, Fasolo A, Perroteau I.

J Biol Chem. 2004 Nov 19;279(47):48808-16. Epub 2004 Sep 8.

12.

Neuregulin1 (NRG1) signaling through Fyn modulates NMDA receptor phosphorylation: differential synaptic function in NRG1+/- knock-outs compared with wild-type mice.

Bjarnadottir M, Misner DL, Haverfield-Gross S, Bruun S, Helgason VG, Stefansson H, Sigmundsson A, Firth DR, Nielsen B, Stefansdottir R, Novak TJ, Stefansson K, Gurney ME, Andresson T.

J Neurosci. 2007 Apr 25;27(17):4519-29.

13.

Antipsychotic treatment and neuregulin 1-ErbB4 signalling in schizophrenia.

Pan B, Huang XF, Deng C.

Prog Neuropsychopharmacol Biol Psychiatry. 2011 Jun 1;35(4):924-30. doi: 10.1016/j.pnpbp.2011.04.002. Epub 2011 Apr 13. Review.

PMID:
21513767
14.

Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice.

Savonenko AV, Melnikova T, Laird FM, Stewart KA, Price DL, Wong PC.

Proc Natl Acad Sci U S A. 2008 Apr 8;105(14):5585-90. doi: 10.1073/pnas.0710373105. Epub 2008 Apr 2.

15.

Control of cortical GABA circuitry development by Nrg1 and ErbB4 signalling.

Fazzari P, Paternain AV, Valiente M, Pla R, Luján R, Lloyd K, Lerma J, Marín O, Rico B.

Nature. 2010 Apr 29;464(7293):1376-80. doi: 10.1038/nature08928. Epub 2010 Apr 14.

PMID:
20393464
16.

Biological validation of increased schizophrenia risk with NRG1, ERBB4, and AKT1 epistasis via functional neuroimaging in healthy controls.

Nicodemus KK, Law AJ, Radulescu E, Luna A, Kolachana B, Vakkalanka R, Rujescu D, Giegling I, Straub RE, McGee K, Gold B, Dean M, Muglia P, Callicott JH, Tan HY, Weinberger DR.

Arch Gen Psychiatry. 2010 Oct;67(10):991-1001. doi: 10.1001/archgenpsychiatry.2010.117.

17.

Perinatal phencyclidine treatment alters neuregulin 1/erbB4 expression and activation in later life.

du Bois TM, Newell KA, Huang XF.

Eur Neuropsychopharmacol. 2012 May;22(5):356-63. doi: 10.1016/j.euroneuro.2011.09.002. Epub 2011 Oct 1.

PMID:
21962913
18.

A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis.

Kainulainen V, Sundvall M, Määttä JA, Santiestevan E, Klagsbrun M, Elenius K.

J Biol Chem. 2000 Mar 24;275(12):8641-9.

19.

PI3K p110delta regulates T-cell cytokine production during primary and secondary immune responses in mice and humans.

Soond DR, Bjørgo E, Moltu K, Dale VQ, Patton DT, Torgersen KM, Galleway F, Twomey B, Clark J, Gaston JS, Taskén K, Bunyard P, Okkenhaug K.

Blood. 2010 Mar 18;115(11):2203-13. doi: 10.1182/blood-2009-07-232330. Epub 2010 Jan 15.

20.

Global signaling effects of a schizophrenia-associated missense mutation in neuregulin 1: an exploratory study using whole genome and novel kinome approaches.

Marballi KK, McCullumsmith RE, Yates S, Escamilla MA, Leach RJ, Raventos H, Walss-Bass C.

J Neural Transm (Vienna). 2014 May;121(5):479-90. doi: 10.1007/s00702-013-1142-6. Epub 2014 Jan 1.

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