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Items: 1 to 20 of 136

1.

Aberrant substrate engagement of the ER translocon triggers degradation by the Hrd1 ubiquitin ligase.

Rubenstein EM, Kreft SG, Greenblatt W, Swanson R, Hochstrasser M.

J Cell Biol. 2012 Jun 11;197(6):761-73. doi: 10.1083/jcb.201203061.

2.

N-terminal acetylation of the yeast Derlin Der1 is essential for Hrd1 ubiquitin-ligase activity toward luminal ER substrates.

Zattas D, Adle DJ, Rubenstein EM, Hochstrasser M.

Mol Biol Cell. 2013 Apr;24(7):890-900. doi: 10.1091/mbc.E12-11-0838. Epub 2013 Jan 30.

3.

The yeast ERAD-C ubiquitin ligase Doa10 recognizes an intramembrane degron.

Habeck G, Ebner FA, Shimada-Kreft H, Kreft SG.

J Cell Biol. 2015 Apr 27;209(2):261-73. doi: 10.1083/jcb.201408088. Erratum in: J Cell Biol. 2015 May 25;209(4):621. J Cell Biol. 2015 Apr 27;209(2):260.

4.
5.

A Conserved C-terminal Element in the Yeast Doa10 and Human MARCH6 Ubiquitin Ligases Required for Selective Substrate Degradation.

Zattas D, Berk JM, Kreft SG, Hochstrasser M.

J Biol Chem. 2016 Jun 3;291(23):12105-18. doi: 10.1074/jbc.M116.726877. Epub 2016 Apr 11.

6.

Spatially regulated ubiquitin ligation by an ER/nuclear membrane ligase.

Deng M, Hochstrasser M.

Nature. 2006 Oct 19;443(7113):827-31.

PMID:
17051211
7.

Derlin2 protein facilitates HRD1-mediated retro-translocation of sonic hedgehog at the endoplasmic reticulum.

Huang CH, Hsiao HT, Chu YR, Ye Y, Chen X.

J Biol Chem. 2013 Aug 30;288(35):25330-9. doi: 10.1074/jbc.M113.455212. Epub 2013 Jul 18.

8.

Rkr1/Ltn1 Ubiquitin Ligase-mediated Degradation of Translationally Stalled Endoplasmic Reticulum Proteins.

Crowder JJ, Geigges M, Gibson RT, Fults ES, Buchanan BW, Sachs N, Schink A, Kreft SG, Rubenstein EM.

J Biol Chem. 2015 Jul 24;290(30):18454-66. doi: 10.1074/jbc.M115.663559. Epub 2015 Jun 8.

9.

Previously unknown role for the ubiquitin ligase Ubr1 in endoplasmic reticulum-associated protein degradation.

Stolz A, Besser S, Hottmann H, Wolf DH.

Proc Natl Acad Sci U S A. 2013 Sep 17;110(38):15271-6. doi: 10.1073/pnas.1304928110. Epub 2013 Aug 29.

11.

A stalled retrotranslocation complex reveals physical linkage between substrate recognition and proteasomal degradation during ER-associated degradation.

Nakatsukasa K, Brodsky JL, Kamura T.

Mol Biol Cell. 2013 Jun;24(11):1765-75, S1-8. doi: 10.1091/mbc.E12-12-0907. Epub 2013 Mar 27.

12.

Direct and essential function for Hrd3 in ER-associated degradation.

Vashistha N, Neal SE, Singh A, Carroll SM, Hampton RY.

Proc Natl Acad Sci U S A. 2016 May 24;113(21):5934-9. doi: 10.1073/pnas.1603079113. Epub 2016 May 11.

13.

Hsp70 targets a cytoplasmic quality control substrate to the San1p ubiquitin ligase.

Guerriero CJ, Weiberth KF, Brodsky JL.

J Biol Chem. 2013 Jun 21;288(25):18506-20. doi: 10.1074/jbc.M113.475905. Epub 2013 May 7.

14.

SEL1L protein critically determines the stability of the HRD1-SEL1L endoplasmic reticulum-associated degradation (ERAD) complex to optimize the degradation kinetics of ERAD substrates.

Iida Y, Fujimori T, Okawa K, Nagata K, Wada I, Hosokawa N.

J Biol Chem. 2011 May 13;286(19):16929-39. doi: 10.1074/jbc.M110.215871. Epub 2011 Mar 24.

15.

Association of the SEL1L protein transmembrane domain with HRD1 ubiquitin ligase regulates ERAD-L.

Hosokawa N, Wada I.

FEBS J. 2016 Jan;283(1):157-72. doi: 10.1111/febs.13564. Epub 2015 Nov 6.

16.

Dfm1 forms distinct complexes with Cdc48 and the ER ubiquitin ligases and is required for ERAD.

Stolz A, Schweizer RS, Schäfer A, Wolf DH.

Traffic. 2010 Oct;11(10):1363-9. doi: 10.1111/j.1600-0854.2010.01093.x.

17.

Modularity of the Hrd1 ERAD complex underlies its diverse client range.

Kanehara K, Xie W, Ng DT.

J Cell Biol. 2010 Mar 8;188(5):707-16. doi: 10.1083/jcb.200907055.

18.
19.

Human HRD1 is an E3 ubiquitin ligase involved in degradation of proteins from the endoplasmic reticulum.

Kikkert M, Doolman R, Dai M, Avner R, Hassink G, van Voorden S, Thanedar S, Roitelman J, Chau V, Wiertz E.

J Biol Chem. 2004 Jan 30;279(5):3525-34. Epub 2003 Oct 30.

20.

USP19-Mediated Deubiquitination Facilitates the Stabilization of HRD1 Ubiquitin Ligase.

Harada K, Kato M, Nakamura N.

Int J Mol Sci. 2016 Nov 2;17(11). pii: E1829.

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