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Items: 1 to 20 of 142

1.

Early rapid identification of in vivo rat metabolites of AN6414, a novel boron-containing PDE4 inhibitor by QTRAP LC/MS/MS to support drug discovery.

Bu W, Akama T, Chanda S, Sullivan D, Ciaravino V, Jarnagin K, Freund Y, Sanders V, Chen CW, Fan X, Heyman I, Liu L.

J Pharm Biomed Anal. 2012 Nov;70:344-53. doi: 10.1016/j.jpba.2012.05.024. Epub 2012 May 28.

PMID:
22687459
2.

In vivo metabolic investigation of moxifloxacin using liquid chromatography/electrospray ionization tandem mass spectrometry in combination with online hydrogen/deuterium exchange experiments.

Raju B, Ramesh M, Borkar RM, Srinivas R, Padiya R, Banerjee SK.

Rapid Commun Mass Spectrom. 2012 Aug 30;26(16):1817-31. doi: 10.1002/rcm.6288.

PMID:
22777784
3.
4.

Identification and structural characterization of in vivo metabolites of ketorolac using liquid chromatography electrospray ionization tandem mass spectrometry (LC/ESI-MS/MS).

Raju B, Ramesh M, Borkar RM, Padiya R, Banerjee SK, Srinivas R.

J Mass Spectrom. 2012 Jul;47(7):919-31. doi: 10.1002/jms.3043.

PMID:
22791260
5.

In vitro metabolite identification of ML3403, a 4-pyridinylimidazole-type p38 MAP kinase inhibitor by LC-Qq-TOF-MS and LC-SPE-cryo-NMR/MS.

Kammerer B, Scheible H, Zurek G, Godejohann M, Zeller KP, Gleiter CH, Albrecht W, Laufer S.

Xenobiotica. 2007 Mar;37(3):280-97.

PMID:
17624026
6.
7.

In vivo metabolite detection and identification in drug discovery via LC-MS/MS with data-dependent scanning and postacquisition data mining.

Triolo A, Altamura M, Dimoulas T, Guidi A, Lecci A, Tramontana M.

J Mass Spectrom. 2005 Dec;40(12):1572-82.

PMID:
16320289
9.

Identification of rat urinary metabolites of rifabutin using LC-MSn and LC-HR-MS.

Prasad B, Singh S.

Eur J Pharm Sci. 2010 Sep 11;41(1):173-88. doi: 10.1016/j.ejps.2010.06.006. Epub 2010 Jun 15.

PMID:
20558285
10.

Identification of in vivo and in vitro metabolites of triptolide by liquid chromatography-tandem mass spectrometry.

Peng ZH, Wang JJ, Du P, Chen Y.

J Pharm Biomed Anal. 2012 Nov;70:624-30. doi: 10.1016/j.jpba.2012.06.026. Epub 2012 Jun 30.

PMID:
22824635
11.

Regiospecific and stereospecific triangulation of the structures of metabolites formed by sequential metabolism at multiple prochiral centers.

Greene RJ, Davis JA, Subramanian R, Deane MR, Emery MG, Slatter JG.

Drug Metab Dispos. 2012 May;40(5):928-42. doi: 10.1124/dmd.111.043166. Epub 2012 Feb 10.

12.

Identifying and overcoming bioanalytical challenges associated with chlorine-containing dehydrogenation metabolites.

Furlong MT, Wujcik CE, Ji C, Su Y.

Rapid Commun Mass Spectrom. 2010 Nov 15;24(21):3092-102. doi: 10.1002/rcm.4741.

PMID:
20941755
13.
14.

Evaluation of a high-throughput online solid phase extraction-tandem mass spectrometry system for in vivo bioanalytical studies.

Jian W, Romm MV, Edom RW, Miller VP, LaMarr WA, Weng N.

Anal Chem. 2011 Nov 1;83(21):8259-66. doi: 10.1021/ac202017c. Epub 2011 Oct 6.

PMID:
21936562
15.

Identification of major metabolites in rat urine and plasma of N(6) -(4-hydroxybenzyl) adenine riboside by LC/MS/MS.

Lei Y, Wang L, Cheng M, Xiao H.

Biomed Chromatogr. 2011 Mar;25(3):344-52. doi: 10.1002/bmc.1452.

PMID:
21110386
17.

Introduction to early in vitro identification of metabolites of new chemical entities in drug discovery and development.

Baranczewski P, StaƄczak A, Kautiainen A, Sandin P, Edlund PO.

Pharmacol Rep. 2006 May-Jun;58(3):341-52. Review.

18.

Use of high-resolution mass spectrometry to investigate a metabolite interference during liquid chromatography/tandem mass spectrometric quantification of a small molecule in toxicokinetic study samples.

Furlong M, Bessire A, Song W, Huntington C, Groeber E.

Rapid Commun Mass Spectrom. 2010 Jul 15;24(13):1902-10. doi: 10.1002/rcm.4587.

PMID:
20533320
20.

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