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Items: 1 to 20 of 102

1.

Twist1 regulates Ifng expression in Th1 cells by interfering with Runx3 function.

Pham D, Vincentz JW, Firulli AB, Kaplan MH.

J Immunol. 2012 Jul 15;189(2):832-40. doi: 10.4049/jimmunol.1200854. Epub 2012 Jun 8.

2.

Transcription factors T-bet and Runx3 cooperate to activate Ifng and silence Il4 in T helper type 1 cells.

Djuretic IM, Levanon D, Negreanu V, Groner Y, Rao A, Ansel KM.

Nat Immunol. 2007 Feb;8(2):145-53. Epub 2006 Dec 31.

PMID:
17195845
3.

T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription.

Usui T, Preiss JC, Kanno Y, Yao ZJ, Bream JH, O'Shea JJ, Strober W.

J Exp Med. 2006 Mar 20;203(3):755-66. Epub 2006 Mar 6. Erratum in: J Exp Med. 2006 Apr 17;203(4):1129.

4.

The Runx3 transcription factor augments Th1 and down-modulates Th2 phenotypes by interacting with and attenuating GATA3.

Kohu K, Ohmori H, Wong WF, Onda D, Wakoh T, Kon S, Yamashita M, Nakayama T, Kubo M, Satake M.

J Immunol. 2009 Dec 15;183(12):7817-24. doi: 10.4049/jimmunol.0802527.

5.

The transcription factor GATA3 actively represses RUNX3 protein-regulated production of interferon-gamma.

Yagi R, Junttila IS, Wei G, Urban JF Jr, Zhao K, Paul WE, Zhu J.

Immunity. 2010 Apr 23;32(4):507-17. doi: 10.1016/j.immuni.2010.04.004. Epub 2010 Apr 15.

6.

IL-21 inhibits IFN-gamma production in developing Th1 cells through the repression of Eomesodermin expression.

Suto A, Wurster AL, Reiner SL, Grusby MJ.

J Immunol. 2006 Sep 15;177(6):3721-7.

7.

The transcription factors T-bet and Runx are required for the ontogeny of pathogenic interferon-γ-producing T helper 17 cells.

Wang Y, Godec J, Ben-Aissa K, Cui K, Zhao K, Pucsek AB, Lee YK, Weaver CT, Yagi R, Lazarevic V.

Immunity. 2014 Mar 20;40(3):355-66. doi: 10.1016/j.immuni.2014.01.002. Epub 2014 Feb 13.

8.

miR-148a is upregulated by Twist1 and T-bet and promotes Th1-cell survival by regulating the proapoptotic gene Bim.

Haftmann C, Stittrich AB, Zimmermann J, Fang Z, Hradilkova K, Bardua M, Westendorf K, Heinz GA, Riedel R, Siede J, Lehmann K, Weinberger EE, Zimmel D, Lauer U, Häupl T, Sieper J, Backhaus M, Neumann C, Hoffmann U, Porstner M, Chen W, Grün JR, Baumgrass R, Matz M, Löhning M, Scheffold A, Wittmann J, Chang HD, Rajewsky N, Jäck HM, Radbruch A, Mashreghi MF.

Eur J Immunol. 2015 Apr;45(4):1192-205. doi: 10.1002/eji.201444633. Epub 2015 Jan 22.

9.

Modular utilization of distal cis-regulatory elements controls Ifng gene expression in T cells activated by distinct stimuli.

Balasubramani A, Shibata Y, Crawford GE, Baldwin AS, Hatton RD, Weaver CT.

Immunity. 2010 Jul 23;33(1):35-47. doi: 10.1016/j.immuni.2010.07.004.

10.

Regulation of IFN-gamma production by B effector 1 cells: essential roles for T-bet and the IFN-gamma receptor.

Harris DP, Goodrich S, Gerth AJ, Peng SL, Lund FE.

J Immunol. 2005 Jun 1;174(11):6781-90.

11.

IFN-alpha is not sufficient to drive Th1 development due to lack of stable T-bet expression.

Ramos HJ, Davis AM, George TC, Farrar JD.

J Immunol. 2007 Sep 15;179(6):3792-803.

12.

Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation.

Pham D, Yu Q, Walline CC, Muthukrishnan R, Blum JS, Kaplan MH.

J Immunol. 2013 Jul 15;191(2):902-11. doi: 10.4049/jimmunol.1203229. Epub 2013 Jun 14.

13.

Sequential polarization and imprinting of type 1 T helper lymphocytes by interferon-gamma and interleukin-12.

Schulz EG, Mariani L, Radbruch A, Höfer T.

Immunity. 2009 May;30(5):673-83. doi: 10.1016/j.immuni.2009.03.013. Epub 2009 Apr 30.

14.

T-bet and eomesodermin play critical roles in directing T cell differentiation to Th1 versus Th17.

Yang Y, Xu J, Niu Y, Bromberg JS, Ding Y.

J Immunol. 2008 Dec 15;181(12):8700-10.

15.

Blimp-1 attenuates Th1 differentiation by repression of ifng, tbx21, and bcl6 gene expression.

Cimmino L, Martins GA, Liao J, Magnusdottir E, Grunig G, Perez RK, Calame KL.

J Immunol. 2008 Aug 15;181(4):2338-47.

16.

Runx3 and T-box proteins cooperate to establish the transcriptional program of effector CTLs.

Cruz-Guilloty F, Pipkin ME, Djuretic IM, Levanon D, Lotem J, Lichtenheld MG, Groner Y, Rao A.

J Exp Med. 2009 Jan 16;206(1):51-9. doi: 10.1084/jem.20081242. Epub 2009 Jan 12.

17.

Autoregulation of Th1-mediated inflammation by twist1.

Niesner U, Albrecht I, Janke M, Doebis C, Loddenkemper C, Lexberg MH, Eulenburg K, Kreher S, Koeck J, Baumgrass R, Bonhagen K, Kamradt T, Enghard P, Humrich JY, Rutz S, Schulze-Topphoff U, Aktas O, Bartfeld S, Radbruch H, Hegazy AN, Löhning M, Baumgart DC, Duchmann R, Rudwaleit M, Häupl T, Gitelman I, Krenn V, Gruen J, Sieper J, Zeitz M, Wiedenmann B, Zipp F, Hamann A, Janitz M, Scheffold A, Burmester GR, Chang HD, Radbruch A.

J Exp Med. 2008 Aug 4;205(8):1889-901. doi: 10.1084/jem.20072468. Epub 2008 Jul 28.

18.

Downregulation of Hlx closely related to the decreased expressions of T-bet and Runx3 in patients with gastric cancer may be associated with a pathological event leading to the imbalance of Th1/Th2.

Xu Y, Gao J, Su Z, Dai X, Li Y, Liu Y, Chen J, Tong J, Zhang Y, Wu C, Zheng D, Wang S, Xu H.

Clin Dev Immunol. 2012;2012:949821. doi: 10.1155/2012/949821. Epub 2012 Nov 19.

19.

T-bet(+) Treg cells undergo abortive Th1 cell differentiation due to impaired expression of IL-12 receptor β2.

Koch MA, Thomas KR, Perdue NR, Smigiel KS, Srivastava S, Campbell DJ.

Immunity. 2012 Sep 21;37(3):501-10. doi: 10.1016/j.immuni.2012.05.031. Epub 2012 Sep 6.

20.

Downregulation of Runx3 is closely related to the decreased Th1-associated factors in patients with gastric carcinoma.

Li Y, Ji X, Su Z, Tong J, Xia S, Chen X, Lu P, Barnie PA, Wang S, Huang X, Xu H.

Tumour Biol. 2014 Dec;35(12):12235-44. doi: 10.1007/s13277-014-2532-6. Epub 2014 Oct 1.

PMID:
25270738

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