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Items: 1 to 20 of 95

1.

The intermediate filament protein, vimentin, is a regulator of NOD2 activity.

Stevens C, Henderson P, Nimmo ER, Soares DC, Dogan B, Simpson KW, Barrett JC; International Inflammatory Bowel Disease Genetics Consortium, Wilson DC, Satsangi J.

Gut. 2013 May;62(5):695-707. doi: 10.1136/gutjnl-2011-301775. Epub 2012 Jun 8. Erratum in: Gut. 2013 May;62(5):707.

2.

TLE1 modifies the effects of NOD2 in the pathogenesis of Crohn's disease.

Nimmo ER, Stevens C, Phillips AM, Smith A, Drummond HE, Noble CL, Quail M, Davies G, Aldhous MC, Wilson DC, Satsangi J.

Gastroenterology. 2011 Sep;141(3):972-981.e1-2. doi: 10.1053/j.gastro.2011.05.043. Epub 2011 May 27.

PMID:
21699783
3.

ATG16L1 and NOD2 interact in an autophagy-dependent antibacterial pathway implicated in Crohn's disease pathogenesis.

Homer CR, Richmond AL, Rebert NA, Achkar JP, McDonald C.

Gastroenterology. 2010 Nov;139(5):1630-41, 1641.e1-2. doi: 10.1053/j.gastro.2010.07.006. Epub 2010 Jul 14.

4.

A role for vimentin in Crohn disease.

Henderson P, Wilson DC, Satsangi J, Stevens C.

Autophagy. 2012 Nov;8(11):1695-6. doi: 10.4161/auto.21690. Epub 2012 Aug 28.

5.

Characterization and Genetic Analyses of New Genes Coding for NOD2 Interacting Proteins.

Thiébaut R, Esmiol S, Lecine P, Mahfouz B, Hermant A, Nicoletti C, Parnis S, Perroy J, Borg JP, Pascoe L, Hugot JP, Ollendorff V.

PLoS One. 2016 Nov 3;11(11):e0165420. doi: 10.1371/journal.pone.0165420. eCollection 2016.

6.

Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease.

Schwerd T, Pandey S, Yang HT, Bagola K, Jameson E, Jung J, Lachmann RH, Shah N, Patel SY, Booth C, Runz H, Düker G, Bettels R, Rohrbach M, Kugathasan S, Chapel H, Keshav S, Elkadri A, Platt N, Muise AM, Koletzko S, Xavier RJ, Marquardt T, Powrie F, Wraith JE, Gyrd-Hansen M, Platt FM, Uhlig HH.

Gut. 2017 Jun;66(6):1060-1073. doi: 10.1136/gutjnl-2015-310382. Epub 2016 Mar 7.

7.

Nucleotide-binding oligomerization domain containing 2: structure, function, and diseases.

Yao Q.

Semin Arthritis Rheum. 2013 Aug;43(1):125-30. doi: 10.1016/j.semarthrit.2012.12.005. Epub 2013 Jan 24. Review.

PMID:
23352252
8.

Crohn's Disease Variants of Nod2 Are Stabilized by the Critical Contact Region of Hsp70.

Schaefer AK, Wastyk HC, Mohanan V, Hou CW, Lauro ML, Melnyk JE, Burch JM, Grimes CL.

Biochemistry. 2017 Aug 29;56(34):4445-4448. doi: 10.1021/acs.biochem.7b00470. Epub 2017 Aug 15.

9.

Toll-like receptor-induced granulocyte-macrophage colony-stimulating factor secretion is impaired in Crohn's disease by nucleotide oligomerization domain 2-dependent and -independent pathways.

Brosbøl-Ravnborg A, Hvas CL, Agnholt J, Dahlerup JF, Vind I, Till A, Rosenstiel P, Höllsberg P.

Clin Exp Immunol. 2009 Mar;155(3):487-95. doi: 10.1111/j.1365-2249.2008.03850.x. Epub 2008 Dec 15.

10.

Enhancement of Muramyl Dipeptide-Dependent NOD2 Activity by a Self-Derived Peptide.

Mann JK, Shen J, Park S.

J Cell Biochem. 2017 May;118(5):1227-1238. doi: 10.1002/jcb.25778. Epub 2017 Jan 10.

PMID:
27791288
11.
12.

miR-122 targets NOD2 to decrease intestinal epithelial cell injury in Crohn's disease.

Chen Y, Wang C, Liu Y, Tang L, Zheng M, Xu C, Song J, Meng X.

Biochem Biophys Res Commun. 2013 Aug 16;438(1):133-9. doi: 10.1016/j.bbrc.2013.07.040. Epub 2013 Jul 19.

PMID:
23872065
13.

The nucleotide synthesis enzyme CAD inhibits NOD2 antibacterial function in human intestinal epithelial cells.

Richmond AL, Kabi A, Homer CR, Marina-García N, Nickerson KP, Nesvizhskii AI, Sreekumar A, Chinnaiyan AM, Nuñez G, McDonald C.

Gastroenterology. 2012 Jun;142(7):1483-92.e6. doi: 10.1053/j.gastro.2012.02.040. Epub 2012 Feb 28.

14.

Epistasis between Toll-like receptor-9 polymorphisms and variants in NOD2 and IL23R modulates susceptibility to Crohn's disease.

Török HP, Glas J, Endres I, Tonenchi L, Teshome MY, Wetzke M, Klein W, Lohse P, Ochsenkühn T, Folwaczny M, Göke B, Folwaczny C, Müller-Myhsok B, Brand S.

Am J Gastroenterol. 2009 Jul;104(7):1723-33. doi: 10.1038/ajg.2009.184. Epub 2009 May 19.

PMID:
19455129
15.

Crohn's disease-associated polymorphism within the PTPN2 gene affects muramyl-dipeptide-induced cytokine secretion and autophagy.

Scharl M, Mwinyi J, Fischbeck A, Leucht K, Eloranta JJ, Arikkat J, Pesch T, Kellermeier S, Mair A, Kullak-Ublick GA, Truninger K, Noreen F, Regula J, Gaj P, Pittet V, Mueller C, Hofmann C, Fried M, McCole DF, Rogler G.

Inflamm Bowel Dis. 2012 May;18(5):900-12. doi: 10.1002/ibd.21913. Epub 2011 Oct 21.

PMID:
22021207
16.

The complex interplay of NOD-like receptors and the autophagy machinery in the pathophysiology of Crohn disease.

Billmann-Born S, Lipinski S, Böck J, Till A, Rosenstiel P, Schreiber S.

Eur J Cell Biol. 2011 Jun-Jul;90(6-7):593-602. doi: 10.1016/j.ejcb.2010.10.015. Epub 2010 Dec 10. Review.

PMID:
21146253
17.

NOD2 downregulates colonic inflammation by IRF4-mediated inhibition of K63-linked polyubiquitination of RICK and TRAF6.

Watanabe T, Asano N, Meng G, Yamashita K, Arai Y, Sakurai T, Kudo M, Fuss IJ, Kitani A, Shimosegawa T, Chiba T, Strober W.

Mucosal Immunol. 2014 Nov;7(6):1312-25. doi: 10.1038/mi.2014.19. Epub 2014 Mar 26.

18.

The molecular chaperone HSP70 binds to and stabilizes NOD2, an important protein involved in Crohn disease.

Mohanan V, Grimes CL.

J Biol Chem. 2014 Jul 4;289(27):18987-98. doi: 10.1074/jbc.M114.557686. Epub 2014 Apr 30.

19.

Genome-wide expression profiling identifies an impairment of negative feedback signals in the Crohn's disease-associated NOD2 variant L1007fsinsC.

Billmann-Born S, Till A, Arlt A, Lipinski S, Sina C, Latiano A, Annese V, Häsler R, Kerick M, Manke T, Seegert D, Hanidu A, Schäfer H, van Heel D, Li J, Schreiber S, Rosenstiel P.

J Immunol. 2011 Apr 1;186(7):4027-38. doi: 10.4049/jimmunol.1000085. Epub 2011 Feb 18.

20.

The NOD2-RICK complex signals from the plasma membrane.

Lécine P, Esmiol S, Métais JY, Nicoletti C, Nourry C, McDonald C, Nunez G, Hugot JP, Borg JP, Ollendorff V.

J Biol Chem. 2007 May 18;282(20):15197-207. Epub 2007 Mar 13.

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