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22683370,25313916,19917273,24632287,26371983,18406350,25278291,22417841,24675665,25857271,26632531,23973703,25014035,18666258,23690465,29284604,25913303,24315769,27206942,23675525,18672372,23537802,20529551,23333725,23400816,24625727,21273557,22176652,25544176,20006333,27596133,25023731,25466598,21920719,24014831,16794006,16777760,31419281,17645871,24122718,25248569,23593297,24252255,21692990,22593575,23129602,29102496,27998977,15118091,21872251,26412029,22244043,22375030,19319977,21943799,22300679,25070550,26195630,17461796,25936324,22261195,22019884,25839937,22992388,17080197,27284008,25881720,26056005,23317404,25395619,24518357,24585268,30270088,18245819,15767856,16424354,26503748,25904765,18836590,23329883,22683120,27888903,25258384,26824363,15166014,25665485,24793346,25123222,17702855,22460556,26586530,25046268,23308045,19797716,23578522,25244623,26256967,25778403,28502498,17452316,22156580,25164566,31491741,23884353,25905719,26576960,26490048,31553664,24160703,26833058,27784735,23135270,26323289,22435370,25896669,28546220,34511120,25463543,25652089,26085104,26293463,25613181,25474576,25649668,33533259,27920219,22809551,33147992,21497351,25519174,25856746,18039658,22580899,23261172,29129821,18033751,16571601,21813713,24094767,19930098,18354138,25456764,24938457,23642323,25791168,19060325,26165249,32913121,22074827,17449864,26252194,21122860,17493938,25971287,28262545,23499248,34991937,20172854,25036764,23283366,21619378,26003826,23714205,33020528,21539517,22848640,25744035,19196236,23553812,25222343,20716520,24951769,23623011,22355267,27458166,25679794,32705598,23371064,25600226,25770756,19075777,26153823,28750079,24144304,23535506,33864011,19601924,23106476,26333678,21889145,20423303,18547436,26415676,23083772,17242417,24308640,26687699,23663650,18052825,26628375,26342106,27967828,23974119,19443683,26343872,25134067,25770357,25911073,28926730,21376320,27919357,22764087,27215417,36263780,36475702,23416791,24166456,18280815,23433768,20498851,23162007,26040332,25291660,23375686,21122852,22001517,26183252,19768174,19571328,22910581,27633999,26896437,18753623,25444750,20073037,22883975,27534510,23537714,26320675,17142622,31767518,25535288,25042549,24115837,19081568,22554600,16183066,25110901,24103783,24352472,24164109,15385538,21411093,27758865,24680982,25782778,24234650,26980204,24667128,23286435,30767742,18648394,23559630,26548330,27150391,21146822,20453200,32088152,18250299,34652028,24632264,26620373,16909389,26036859,19628659,24603306,32078365,36626903,23509406,28964736,19878649,23450051,27015087,22081141,29467219,17537735,24785115,24916110,24721682,31779098,18799458,20959675,26892515,25653417,30555118,31518966,15358785,30318064,20448210,28495363,26350813,25712136,36077166,19224862,20525997,28506389,32878475,21324305,29127338,26482752,21518694,19635789,28726204,29852278,22027821,22095935,26494228,35174858,25412415,29699916,24267230,32163632,35510551,23380568,27130349,36207148,32495699,19738285,36834740,33119548,32846800,24114461,19713274,25889684,33177004,25823668,26445568,36087353,28762908,21232153,22519528,23087140,23422832,25349780,22311433,33419720,25432415,32252761,25461735,27031271,15741654,25341796,23642322,19001363,32769621,28965616,29982529,24917546,26578202,29269200,35981632,28145001,30634533,21332221,26143741,26049403,32770674,28919772,30838555,27115873,24685817,22875854,21596380,16465619,27919364,30641718,22964999,35307759,26160041,17094996,23690464,24607922,25496400,35263196,22611251,27496869,21868016,25682035,18695239,24529132,17921436,28459663,22575316,32673528,31949048,27038318,35162992,18354137,25410128,26547624,27552305,23743349,17971861,31004037,25414277,24859266,20809525,21040917,30415195,30695320,27218270,23544125,22728257,29209403,26023080,24296664,32349585,30463987,32051094,25035151,33461570,24801085,24769476,20048381,28363723,33642545,35344222,32929056,32469502,29332570,30710474,26541928,29548750,30056842,24659111,22294733,29665987,25128757,26684558,27171436,21149300,24486405,37103355,32624555,24548670,30241732,31867167,32911577,25484037,30044755,33276863,32423823,24506872,36771126,28987238,31441123,23883163,26987067,21787450,19063703,30914377,18436719,33229322,22051553,30768966,20623344,30910667,28506388,32398139,27128549,25172631,30910740,29396908,24314353,24614537,30522786,28870033,35217376,24987033,28549755,34615375,25234562,30235833,22481440,29233637,17140581,30582457,27358438,30551367,34380071,21771976,18006936,26354227,30950043,29084995,28826253,32794575,29398508,23951290,29050560,27846466,25846081,29428206,25256660,29982592,36427678,31358055,36960729,28502508,28108631,32479195,32496664,24225950,34593126,35964656,17351764,14727156,26960892,30925519,15654334,27374222,23898695,35717446,36980941,29210646,27575716,28691419,29618348,25210046,15772090,27713142,28204827,25621930,31260298,31100618,26894473,22493497,26543100,27470509,28196290,33740630,24440079,28159968,23105118,25180781,22207727,28412198,24993334,35979295,17117756,26802983,28587771,26377225,26508163,19265033,28456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Year	Number of Results
1982	2
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1,506 results

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Page 1

Serum levels of proprotein convertase subtilisin/kexin type 9 in subjects with familial hypercholesterolemia indicate that proprotein convertase subtilisin/kexin type 9 is cleared from plasma by low-density lipoprotein receptor-independent pathways.

Cameron J, Bogsrud MP, Tveten K, Strøm TB, Holven K, Berge KE, Leren TP. Cameron J, et al. Transl Res. 2012 Aug;160(2):125-30. doi: 10.1016/j.trsl.2012.01.010. Epub 2012 Jan 31. Transl Res. 2012. PMID: 22683370

Removal of plasma mature and furin-cleaved proprotein convertase subtilisin/kexin 9 by low-density lipoprotein-apheresis in familial hypercholesterolemia: development and application of a new assay for PCSK9.

Hori M, Ishihara M, Yuasa Y, Makino H, Yanagi K, Tamanaha T, Kishimoto I, Kujiraoka T, Hattori H, Harada-Shiba M. Hori M, et al. J Clin Endocrinol Metab. 2015 Jan;100(1):E41-9. doi: 10.1210/jc.2014-3066. J Clin Endocrinol Metab. 2015. PMID: 25313916

Loss-of-function mutation R46L in the PCSK9 gene has little impact on the levels of total serum cholesterol in familial hypercholesterolemia heterozygotes.

Strøm TB, Holla ØL, Cameron J, Berge KE, Leren TP. Strøm TB, et al. Clin Chim Acta. 2010 Feb;411(3-4):229-33. doi: 10.1016/j.cca.2009.11.008. Epub 2009 Nov 13. Clin Chim Acta. 2010. PMID: 19917273

Elevated plasma PCSK9 level is equally detrimental for patients with nonfamilial hypercholesterolemia and heterozygous familial hypercholesterolemia, irrespective of low-density lipoprotein receptor defects.

Lambert G, Petrides F, Chatelais M, Blom DJ, Choque B, Tabet F, Wong G, Rye KA, Hooper AJ, Burnett JR, Barter PJ, Marais AD. Lambert G, et al. J Am Coll Cardiol. 2014 Jun 10;63(22):2365-73. doi: 10.1016/j.jacc.2014.02.538. Epub 2014 Mar 12. J Am Coll Cardiol. 2014. PMID: 24632287 Free article.

The contribution of PCSK9 levels to the phenotypic severity of familial hypercholesterolemia is independent of LDL receptor genotype.

Drouin-Chartier JP, Tremblay AJ, Hogue JC, Ooi TC, Lamarche B, Couture P. Drouin-Chartier JP, et al. Metabolism. 2015 Nov;64(11):1541-7. doi: 10.1016/j.metabol.2015.08.007. Epub 2015 Aug 20. Metabolism. 2015. PMID: 26371983

Secreted proprotein convertase subtilisin/kexin type 9 reduces both hepatic and extrahepatic low-density lipoprotein receptors in vivo.

Schmidt RJ, Beyer TP, Bensch WR, Qian YW, Lin A, Kowala M, Alborn WE, Konrad RJ, Cao G. Schmidt RJ, et al. Biochem Biophys Res Commun. 2008 Jun 13;370(4):634-40. doi: 10.1016/j.bbrc.2008.04.004. Epub 2008 Apr 10. Biochem Biophys Res Commun. 2008. PMID: 18406350

PCSK9 R46L, lower LDL, and cardiovascular disease risk in familial hypercholesterolemia: a cross-sectional cohort study.

Saavedra YG, Dufour R, Davignon J, Baass A. Saavedra YG, et al. Arterioscler Thromb Vasc Biol. 2014 Dec;34(12):2700-5. doi: 10.1161/ATVBAHA.114.304406. Epub 2014 Oct 2. Arterioscler Thromb Vasc Biol. 2014. PMID: 25278291

Effect of mutations in LDLR and PCSK9 genes on phenotypic variability in Tunisian familial hypercholesterolemia patients.

Slimani A, Jelassi A, Jguirim I, Najah M, Rebhi L, Omezzine A, Maatouk F, Hamda KB, Kacem M, Rabès JP, Abifadel M, Boileau C, Rouis M, Slimane MN, Varret M. Slimani A, et al. Atherosclerosis. 2012 May;222(1):158-66. doi: 10.1016/j.atherosclerosis.2012.02.018. Epub 2012 Feb 19. Atherosclerosis. 2012. PMID: 22417841

Hepatic overexpression of idol increases circulating protein convertase subtilisin/kexin type 9 in mice and hamsters via dual mechanisms: sterol regulatory element-binding protein 2 and low-density lipoprotein receptor-dependent pathways.

Sasaki M, Terao Y, Ayaori M, Uto-Kondo H, Iizuka M, Yogo M, Hagisawa K, Takiguchi S, Yakushiji E, Nakaya K, Ogura M, Komatsu T, Ikewaki K. Sasaki M, et al. Arterioscler Thromb Vasc Biol. 2014 Jun;34(6):1171-8. doi: 10.1161/ATVBAHA.113.302670. Epub 2014 Mar 27. Arterioscler Thromb Vasc Biol. 2014. PMID: 24675665

Serum proprotein convertase subtilisin/kexin type 9 concentration is not increased by plant stanol ester consumption in normo- to moderately hypercholesterolaemic non-obese subjects. The BLOOD FLOW intervention study.

Simonen P, Stenman UH, Gylling H. Simonen P, et al. Clin Sci (Lond). 2015 Sep;129(5):439-46. doi: 10.1042/CS20150193. Epub 2015 Apr 10. Clin Sci (Lond). 2015. PMID: 25857271 Clinical Trial.

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