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Items: 1 to 20 of 77

1.

Molecular mechanism of hepcidin-mediated ferroportin internalization requires ferroportin lysines, not tyrosines or JAK-STAT.

Ross SL, Tran L, Winters A, Lee KJ, Plewa C, Foltz I, King C, Miranda LP, Allen J, Beckman H, Cooke KS, Moody G, Sasu BJ, Nemeth E, Ganz T, Molineux G, Arvedson TL.

Cell Metab. 2012 Jun 6;15(6):905-17. doi: 10.1016/j.cmet.2012.03.017.

2.

Hepcidin-induced endocytosis of ferroportin is dependent on ferroportin ubiquitination.

Qiao B, Sugianto P, Fung E, Del-Castillo-Rueda A, Moran-Jimenez MJ, Ganz T, Nemeth E.

Cell Metab. 2012 Jun 6;15(6):918-24. doi: 10.1016/j.cmet.2012.03.018.

3.

The role of ubiquitination in hepcidin-independent and hepcidin-dependent degradation of ferroportin.

De Domenico I, Lo E, Yang B, Korolnek T, Hamza I, Ward DM, Kaplan J.

Cell Metab. 2011 Nov 2;14(5):635-46. doi: 10.1016/j.cmet.2011.09.008. Epub 2011 Oct 20. Retraction in: Cell Metab. 2012 Jun 6;15(6):927.

4.

The molecular mechanism of hepcidin-mediated ferroportin down-regulation.

De Domenico I, Ward DM, Langelier C, Vaughn MB, Nemeth E, Sundquist WI, Ganz T, Musci G, Kaplan J.

Mol Biol Cell. 2007 Jul;18(7):2569-78. Epub 2007 May 2.

5.

A convenient luminescence assay of ferroportin internalization to study its interaction with hepcidin.

Song G, Jiang Q, Xu T, Liu YL, Xu ZG, Guo ZY.

FEBS J. 2013 Apr;280(8):1773-81. doi: 10.1111/febs.12192. Epub 2013 Mar 11.

6.

Human mutation D157G in ferroportin leads to hepcidin-independent binding of Jak2 and ferroportin down-regulation.

De Domenico I, Lo E, Ward DM, Kaplan J.

Blood. 2010 Apr 8;115(14):2956-9. doi: 10.1182/blood-2009-10-251306. Epub 2010 Feb 2.

7.

Hepcidin-induced internalization of ferroportin requires binding and cooperative interaction with Jak2.

De Domenico I, Lo E, Ward DM, Kaplan J.

Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3800-5. doi: 10.1073/pnas.0900453106. Epub 2009 Feb 20. Erratum in: Proc Natl Acad Sci U S A. 2012 May 8;109(19):7583-6.

8.

Effect of ferroportin polymorphism on iron homeostasis and infection.

Kasvosve I.

Clin Chim Acta. 2013 Feb 1;416:20-5. doi: 10.1016/j.cca.2012.11.013. Epub 2012 Nov 21. Review.

PMID:
23178444
9.

Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice.

De Domenico I, Zhang TY, Koening CL, Branch RW, London N, Lo E, Daynes RA, Kushner JP, Li D, Ward DM, Kaplan J.

J Clin Invest. 2010 Jul;120(7):2395-405. doi: 10.1172/JCI42011. Epub 2010 Jun 7.

10.

Anemic copper-deficient rats, but not mice, display low hepcidin expression and high ferroportin levels.

Jenkitkasemwong S, Broderius M, Nam H, Prohaska JR, Knutson MD.

J Nutr. 2010 Apr;140(4):723-30. doi: 10.3945/jn.109.117077. Epub 2010 Feb 17.

11.

Resistance to hepcidin is conferred by hemochromatosis-associated mutations of ferroportin.

Drakesmith H, Schimanski LM, Ormerod E, Merryweather-Clarke AT, Viprakasit V, Edwards JP, Sweetland E, Bastin JM, Cowley D, Chinthammitr Y, Robson KJ, Townsend AR.

Blood. 2005 Aug 1;106(3):1092-7. Epub 2005 Apr 14.

12.

The molecular basis of hepcidin-resistant hereditary hemochromatosis.

Fernandes A, Preza GC, Phung Y, De Domenico I, Kaplan J, Ganz T, Nemeth E.

Blood. 2009 Jul 9;114(2):437-43. doi: 10.1182/blood-2008-03-146134. Epub 2009 Apr 21.

13.

Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization.

Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T, Kaplan J.

Science. 2004 Dec 17;306(5704):2090-3. Epub 2004 Oct 28.

15.

Iron supply determines apical/basolateral membrane distribution of intestinal iron transporters DMT1 and ferroportin 1.

Núñez MT, Tapia V, Rojas A, Aguirre P, Gómez F, Nualart F.

Am J Physiol Cell Physiol. 2010 Mar;298(3):C477-85. doi: 10.1152/ajpcell.00168.2009. Epub 2009 Dec 9.

16.

Hepcidin expression in human airway epithelial cells is regulated by interferon-γ.

Frazier MD, Mamo LB, Ghio AJ, Turi JL.

Respir Res. 2011 Aug 2;12:100. doi: 10.1186/1465-9921-12-100.

17.

Hepcidin inhibits apical iron uptake in intestinal cells.

Mena NP, Esparza A, Tapia V, Valdés P, Núñez MT.

Am J Physiol Gastrointest Liver Physiol. 2008 Jan;294(1):G192-8. Epub 2007 Oct 25.

18.

Functional consequences of ferroportin 1 mutations.

Liu XB, Yang F, Haile DJ.

Blood Cells Mol Dis. 2005 Jul-Aug;35(1):33-46.

PMID:
15935710
19.

The molecular basis of ferroportin-linked hemochromatosis.

De Domenico I, Ward DM, Nemeth E, Vaughn MB, Musci G, Ganz T, Kaplan J.

Proc Natl Acad Sci U S A. 2005 Jun 21;102(25):8955-60. Epub 2005 Jun 13.

20.

A novel small molecule deubiquitinase inhibitor blocks Jak2 signaling through Jak2 ubiquitination.

Kapuria V, Levitzki A, Bornmann WG, Maxwell D, Priebe W, Sorenson RJ, Showalter HD, Talpaz M, Donato NJ.

Cell Signal. 2011 Dec;23(12):2076-85. doi: 10.1016/j.cellsig.2011.08.002. Epub 2011 Aug 9.

PMID:
21855629

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