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Dysregulated Krüppel-like factor 4 and vitamin D receptor signaling contribute to progression of hepatocellular carcinoma.

Li Q, Gao Y, Jia Z, Mishra L, Guo K, Li Z, Le X, Wei D, Huang S, Xie K.

Gastroenterology. 2012 Sep;143(3):799-810.e1-2. doi: 10.1053/j.gastro.2012.05.043. Epub 2012 Jun 4.


Interleukin-8 Induces Expression of FOXC1 to Promote Transactivation of CXCR1 and CCL2 in Hepatocellular Carcinoma Cell Lines and Formation of Metastases in Mice.

Huang W, Chen Z, Zhang L, Tian D, Wang D, Fan D, Wu K, Xia L.

Gastroenterology. 2015 Oct;149(4):1053-67.e14. doi: 10.1053/j.gastro.2015.05.058. Epub 2015 Jun 9.


FoxM1 overexpression promotes epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma.

Meng FD, Wei JC, Qu K, Wang ZX, Wu QF, Tai MH, Liu HC, Zhang RY, Liu C.

World J Gastroenterol. 2015 Jan 7;21(1):196-213. doi: 10.3748/wjg.v21.i1.196.


Overexpression of brachyury contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma.

Du R, Wu S, Lv X, Fang H, Wu S, Kang J.

J Exp Clin Cancer Res. 2014 Dec 14;33:105. doi: 10.1186/s13046-014-0105-6.


Krüppel-like factor 4, a tumor suppressor in hepatocellular carcinoma cells reverts epithelial mesenchymal transition by suppressing slug expression.

Lin ZS, Chu HC, Yen YC, Lewis BC, Chen YW.

PLoS One. 2012;7(8):e43593. doi: 10.1371/journal.pone.0043593. Epub 2012 Aug 24. Erratum in: PLoS One. 2016;11(4):e0154168. PLoS One. 2013;8(12). doi:10.1371/annotation/af3b480b-2a5a-4483-a98d-82476b314ec1.


Epigenetic alterations of Krüppel-like factor 4 and its tumor suppressor function in renal cell carcinoma.

Li H, Wang J, Xiao W, Xia D, Lang B, Yu G, Guo X, Guan W, Wang Z, Hu Z, Liu J, Ye Z, Xu H.

Carcinogenesis. 2013 Oct;34(10):2262-70. doi: 10.1093/carcin/bgt189. Epub 2013 May 30.


Histone deacetylases activate hepatocyte growth factor signaling by repressing microRNA-449 in hepatocellular carcinoma cells.

Buurman R, Gürlevik E, Schäffer V, Eilers M, Sandbothe M, Kreipe H, Wilkens L, Schlegelberger B, Kühnel F, Skawran B.

Gastroenterology. 2012 Sep;143(3):811-20.e1-15. doi: 10.1053/j.gastro.2012.05.033. Epub 2012 May 26.


mTORC1 Up-Regulates GP73 to Promote Proliferation and Migration of Hepatocellular Carcinoma Cells and Growth of Xenograft Tumors in Mice.

Chen X, Wang Y, Tao J, Shi Y, Gai X, Huang F, Ma Q, Zhou Z, Chen H, Zhang H, Liu Z, Sun Q, Peng H, Chen R, Jing Y, Yang H, Mao Y, Zhang H.

Gastroenterology. 2015 Sep;149(3):741-52.e14. doi: 10.1053/j.gastro.2015.05.005. Epub 2015 May 14.


Transcription factor KLF9 suppresses the growth of hepatocellular carcinoma cells in vivo and positively regulates p53 expression.

Sun J, Wang B, Liu Y, Zhang L, Ma A, Yang Z, Ji Y, Liu Y.

Cancer Lett. 2014 Dec 1;355(1):25-33. doi: 10.1016/j.canlet.2014.09.022. Epub 2014 Sep 19.


Overexpressed HDGF as an independent prognostic factor is involved in poor prognosis in Chinese patients with liver cancer.

Zhou Y, Zhou N, Fang W, Huo J.

Diagn Pathol. 2010 Sep 16;5:58. doi: 10.1186/1746-1596-5-58.


Loss of ATOH8 Increases Stem Cell Features of Hepatocellular Carcinoma Cells.

Song Y, Pan G, Chen L, Ma S, Zeng T, Man Chan TH, Li L, Lian Q, Chow R, Cai X, Li Y, Li Y, Liu M, Li Y, Zhu Y, Wong N, Yuan YF, Pei D, Guan XY.

Gastroenterology. 2015 Oct;149(4):1068-81.e5. doi: 10.1053/j.gastro.2015.06.010. Epub 2015 Jun 20.


MicroRNA-21 suppresses PTEN and hSulf-1 expression and promotes hepatocellular carcinoma progression through AKT/ERK pathways.

Bao L, Yan Y, Xu C, Ji W, Shen S, Xu G, Zeng Y, Sun B, Qian H, Chen L, Wu M, Su C, Chen J.

Cancer Lett. 2013 Sep 1;337(2):226-36. doi: 10.1016/j.canlet.2013.05.007. Epub 2013 May 14.


Isomalto oligosaccharide sulfate inhibits tumor growth and metastasis of hepatocellular carcinoma in nude mice.

Xiao CL, Tao ZH, Guo L, Li WW, Wan JL, Sun HC, Wang L, Tang ZY, Fan J, Wu WZ.

BMC Cancer. 2011 Apr 22;11:150. doi: 10.1186/1471-2407-11-150.


Overexpression of HOXA1 correlates with poor prognosis in patients with hepatocellular carcinoma.

Zha TZ, Hu BS, Yu HF, Tan YF, Zhang Y, Zhang K.

Tumour Biol. 2012 Dec;33(6):2125-34. doi: 10.1007/s13277-012-0472-6. Epub 2012 Aug 4.


F-box protein FBXO22 mediates polyubiquitination and degradation of KLF4 to promote hepatocellular carcinoma progression.

Tian X, Dai S, Sun J, Jin G, Jiang S, Meng F, Li Y, Wu D, Jiang Y.

Oncotarget. 2015 Sep 8;6(26):22767-75.


KLF4-mediated negative regulation of IFITM3 expression plays a critical role in colon cancer pathogenesis.

Li D, Peng Z, Tang H, Wei P, Kong X, Yan D, Huang F, Li Q, Le X, Li Q, Xie K.

Clin Cancer Res. 2011 Jun 1;17(11):3558-68. doi: 10.1158/1078-0432.CCR-10-2729. Epub 2011 Apr 29.


Epigenetic activation of the MiR-200 family contributes to H19-mediated metastasis suppression in hepatocellular carcinoma.

Zhang L, Yang F, Yuan JH, Yuan SX, Zhou WP, Huo XS, Xu D, Bi HS, Wang F, Sun SH.

Carcinogenesis. 2013 Mar;34(3):577-86. doi: 10.1093/carcin/bgs381. Epub 2012 Dec 7.


Reciprocal activation between ATPase inhibitory factor 1 and NF-κB drives hepatocellular carcinoma angiogenesis and metastasis.

Song R, Song H, Liang Y, Yin D, Zhang H, Zheng T, Wang J, Lu Z, Song X, Pei T, Qin Y, Li Y, Xie C, Sun B, Shi H, Li S, Meng X, Yang G, Pan S, Zhu J, Qi S, Jiang H, Zhang Z, Liu L.

Hepatology. 2014 Nov;60(5):1659-73. doi: 10.1002/hep.27312. Epub 2014 Oct 2.


Interferon-stimulated gene 15 (ISG15) is a trigger for tumorigenesis and metastasis of hepatocellular carcinoma.

Li C, Wang J, Zhang H, Zhu M, Chen F, Hu Y, Liu H, Zhu H.

Oncotarget. 2014 Sep 30;5(18):8429-41.


Upregulated FoxM1 expression induced by hepatitis B virus X protein promotes tumor metastasis and indicates poor prognosis in hepatitis B virus-related hepatocellular carcinoma.

Xia L, Huang W, Tian D, Zhu H, Zhang Y, Hu H, Fan D, Nie Y, Wu K.

J Hepatol. 2012 Sep;57(3):600-12. doi: 10.1016/j.jhep.2012.04.020. Epub 2012 May 18.

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