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Items: 1 to 20 of 93

1.

On the mechanism of action of SJ-172550 in inhibiting the interaction of MDM4 and p53.

Bista M, Smithson D, Pecak A, Salinas G, Pustelny K, Min J, Pirog A, Finch K, Zdzalik M, Waddell B, Wladyka B, Kedracka-Krok S, Dyer MA, Dubin G, Guy RK.

PLoS One. 2012;7(6):e37518. doi: 10.1371/journal.pone.0037518. Epub 2012 Jun 4.

2.

Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX.

Pazgier M, Liu M, Zou G, Yuan W, Li C, Li C, Li J, Monbo J, Zella D, Tarasov SG, Lu W.

Proc Natl Acad Sci U S A. 2009 Mar 24;106(12):4665-70. doi: 10.1073/pnas.0900947106. Epub 2009 Mar 2.

3.

Identification and characterization of the first small molecule inhibitor of MDMX.

Reed D, Shen Y, Shelat AA, Arnold LA, Ferreira AM, Zhu F, Mills N, Smithson DC, Regni CA, Bashford D, Cicero SA, Schulman BA, Jochemsen AG, Guy RK, Dyer MA.

J Biol Chem. 2010 Apr 2;285(14):10786-96. doi: 10.1074/jbc.M109.056747. Epub 2010 Jan 15.

4.

Novel simplified yeast-based assays of regulators of p53-MDMX interaction and p53 transcriptional activity.

Leão M, Gomes S, Soares J, Bessa C, Maciel C, Ciribilli Y, Pereira C, Inga A, Saraiva L.

FEBS J. 2013 Dec;280(24):6498-507. doi: 10.1111/febs.12552. Epub 2013 Oct 23.

5.

Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain.

Popowicz GM, Czarna A, Holak TA.

Cell Cycle. 2008 Aug;7(15):2441-3. Epub 2008 May 27.

PMID:
18677113
6.

Puzzling over MDM4-p53 network.

Mancini F, Di Conza G, Monti O, Macchiarulo A, Pellicciari R, Pontecorvi A, Moretti F.

Int J Biochem Cell Biol. 2010 Jul;42(7):1080-3. doi: 10.1016/j.biocel.2010.04.010. Epub 2010 Apr 22. Review.

PMID:
20417304
7.

Molecular basis for the inhibition of p53 by Mdmx.

Popowicz GM, Czarna A, Rothweiler U, Szwagierczak A, Krajewski M, Weber L, Holak TA.

Cell Cycle. 2007 Oct 1;6(19):2386-92. Epub 2007 Oct 12.

PMID:
17938582
8.

MDMX: from bench to bedside.

Marine JC, Dyer MA, Jochemsen AG.

J Cell Sci. 2007 Feb 1;120(Pt 3):371-8. Review.

9.

Studying p53 family proteins in yeast: induction of autophagic cell death and modulation by interactors and small molecules.

Leão M, Gomes S, Bessa C, Soares J, Raimundo L, Monti P, Fronza G, Pereira C, Saraiva L.

Exp Cell Res. 2015 Jan 1;330(1):164-77. doi: 10.1016/j.yexcr.2014.09.028. Epub 2014 Sep 28.

PMID:
25265062
10.

Secondary interaction between MDMX and p53 core domain inhibits p53 DNA binding.

Wei X, Wu S, Song T, Chen L, Gao M, Borcherds W, Daughdrill GW, Chen J.

Proc Natl Acad Sci U S A. 2016 May 10;113(19):E2558-63. doi: 10.1073/pnas.1603838113. Epub 2016 Apr 25.

11.

Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes.

Kallen J, Goepfert A, Blechschmidt A, Izaac A, Geiser M, Tavares G, Ramage P, Furet P, Masuya K, Lisztwan J.

J Biol Chem. 2009 Mar 27;284(13):8812-21. doi: 10.1074/jbc.M809096200. Epub 2009 Jan 19.

12.

Affinity-based screening of MDM2/MDMX-p53 interaction inhibitors by chemical array: identification of novel peptidic inhibitors.

Noguchi T, Oishi S, Honda K, Kondoh Y, Saito T, Kubo T, Kaneda M, Ohno H, Osada H, Fujii N.

Bioorg Med Chem Lett. 2013 Jul 1;23(13):3802-5. doi: 10.1016/j.bmcl.2013.04.094. Epub 2013 May 15.

PMID:
23726030
13.

Optimal Affinity Enhancement by a Conserved Flexible Linker Controls p53 Mimicry in MdmX.

Borcherds W, Becker A, Chen L, Chen J, Chemes LB, Daughdrill GW.

Biophys J. 2017 May 23;112(10):2038-2042. doi: 10.1016/j.bpj.2017.04.017. Epub 2017 May 6.

PMID:
28487147
14.
15.

Targeting the conformational transitions of MDM2 and MDMX: insights into key residues affecting p53 recognition.

Carotti A, Macchiarulo A, Giacchè N, Pellicciari R.

Proteins. 2009 Nov 15;77(3):524-35. doi: 10.1002/prot.22464.

PMID:
19507240
16.

Abnormal MDMX degradation in tumor cells due to ARF deficiency.

Li X, Gilkes D, Li B, Cheng Q, Pernazza D, Lawrence H, Lawrence N, Chen J.

Oncogene. 2012 Aug 9;31(32):3721-32. doi: 10.1038/onc.2011.534. Epub 2011 Nov 28.

17.

High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx.

Czarna A, Popowicz GM, Pecak A, Wolf S, Dubin G, Holak TA.

Cell Cycle. 2009 Apr 15;8(8):1176-84. Epub 2009 Apr 16.

PMID:
19305137
18.

Mdmx as an essential regulator of p53 activity.

Marine JC, Jochemsen AG.

Biochem Biophys Res Commun. 2005 Jun 10;331(3):750-60. Review.

PMID:
15865931
19.

Regulation of p53: a collaboration between Mdm2 and Mdmx.

Pei D, Zhang Y, Zheng J.

Oncotarget. 2012 Mar;3(3):228-35. Review.

20.

Proximity-enabled bioreactivity to generate covalent peptide inhibitors of p53-Mdm4.

Hoppmann C, Wang L.

Chem Commun (Camb). 2016 Apr 14;52(29):5140-3. doi: 10.1039/c6cc01226d. Epub 2016 Mar 21.

PMID:
26996321

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