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Antibody-dependent cellular cytotoxicity against primary HIV-infected CD4+ T cells is directly associated with the magnitude of surface IgG binding.

Smalls-Mantey A, Doria-Rose N, Klein R, Patamawenu A, Migueles SA, Ko SY, Hallahan CW, Wong H, Liu B, You L, Scheid J, Kappes JC, Ochsenbauer C, Nabel GJ, Mascola JR, Connors M.

J Virol. 2012 Aug;86(16):8672-80. doi: 10.1128/JVI.00287-12. Epub 2012 Jun 6.


HIV-specific CD4-induced Antibodies Mediate Broad and Potent Antibody-dependent Cellular Cytotoxicity Activity and Are Commonly Detected in Plasma From HIV-infected humans.

Williams KL, Cortez V, Dingens AS, Gach JS, Rainwater S, Weis JF, Chen X, Spearman P, Forthal DN, Overbaugh J.

EBioMedicine. 2015 Oct;2(10):1464-77.


Short Communication: Small-Molecule CD4 Mimetics Sensitize HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity by Antibodies Elicited by Multiple Envelope Glycoprotein Immunogens in Nonhuman Primates.

Ding S, Verly MM, Princiotto A, Melillo B, Moody AM, Bradley T, Easterhoff D, Roger M, Hahn BH, Madani N, Smith AB 3rd, Haynes BF, Sodroski J, Finzi A.

AIDS Res Hum Retroviruses. 2017 May;33(5):428-431. doi: 10.1089/AID.2016.0246. Epub 2016 Dec 19.


Interaction with cellular CD4 exposes HIV-1 envelope epitopes targeted by antibody-dependent cell-mediated cytotoxicity.

Veillette M, Désormeaux A, Medjahed H, Gharsallah NE, Coutu M, Baalwa J, Guan Y, Lewis G, Ferrari G, Hahn BH, Haynes BF, Robinson JE, Kaufmann DE, Bonsignori M, Sodroski J, Finzi A.

J Virol. 2014 Mar;88(5):2633-44. doi: 10.1128/JVI.03230-13. Epub 2013 Dec 18.


A novel assay for antibody-dependent cell-mediated cytotoxicity against HIV-1- or SIV-infected cells reveals incomplete overlap with antibodies measured by neutralization and binding assays.

Alpert MD, Heyer LN, Williams DE, Harvey JD, Greenough T, Allhorn M, Evans DT.

J Virol. 2012 Nov;86(22):12039-52. doi: 10.1128/JVI.01650-12. Epub 2012 Aug 29.


Effect of Combination Antiretroviral Therapy on HIV-1-specific Antibody-Dependent Cellular Cytotoxicity Responses in Subtype B- and Subtype C-Infected Cohorts.

Madhavi V, Kulkarni A, Shete A, Lee WS, Mclean MR, Kristensen AB, Ghate M, Wines BD, Hogarth PM, Parsons MS, Kelleher A, Cooper DA, Amin J, Emery S, Thakar M, Kent SJ; ENCORE1 Study Group.

J Acquir Immune Defic Syndr. 2017 Jul 1;75(3):345-353. doi: 10.1097/QAI.0000000000001380.


Co-receptor Binding Site Antibodies Enable CD4-Mimetics to Expose Conserved Anti-cluster A ADCC Epitopes on HIV-1 Envelope Glycoproteins.

Richard J, Pacheco B, Gohain N, Veillette M, Ding S, Alsahafi N, Tolbert WD, Prévost J, Chapleau JP, Coutu M, Jia M, Brassard N, Park J, Courter JR, Melillo B, Martin L, Tremblay C, Hahn BH, Kaufmann DE, Wu X, Smith AB 3rd, Sodroski J, Pazgier M, Finzi A.

EBioMedicine. 2016 Oct;12:208-218. doi: 10.1016/j.ebiom.2016.09.004. Epub 2016 Sep 9.


Antibody-Dependent Cellular Cytotoxicity against Reactivated HIV-1-Infected Cells.

Lee WS, Richard J, Lichtfuss M, Smith AB 3rd, Park J, Courter JR, Melillo BN, Sodroski JG, Kaufmann DE, Finzi A, Parsons MS, Kent SJ.

J Virol. 2015 Dec 9;90(4):2021-30. doi: 10.1128/JVI.02717-15. Print 2016 Feb 15.


HIV-1 Antibody Neutralization Breadth Is Associated with Enhanced HIV-Specific CD4+ T Cell Responses.

Ranasinghe S, Soghoian DZ, Lindqvist M, Ghebremichael M, Donaghey F, Carrington M, Seaman MS, Kaufmann DE, Walker BD, Porichis F.

J Virol. 2015 Dec 9;90(5):2208-20. doi: 10.1128/JVI.02278-15.


Achieving Potent Autologous Neutralizing Antibody Responses against Tier 2 HIV-1 Viruses by Strategic Selection of Envelope Immunogens.

Hessell AJ, Malherbe DC, Pissani F, McBurney S, Krebs SJ, Gomes M, Pandey S, Sutton WF, Burwitz BJ, Gray M, Robins H, Park BS, Sacha JB, LaBranche CC, Fuller DH, Montefiori DC, Stamatatos L, Sather DN, Haigwood NL.

J Immunol. 2016 Apr 1;196(7):3064-78. doi: 10.4049/jimmunol.1500527. Epub 2016 Mar 4.


Nef Proteins from HIV-1 Elite Controllers Are Inefficient at Preventing Antibody-Dependent Cellular Cytotoxicity.

Alsahafi N, Ding S, Richard J, Markle T, Brassard N, Walker B, Lewis GK, Kaufmann DE, Brockman MA, Finzi A.

J Virol. 2015 Dec 30;90(6):2993-3002. doi: 10.1128/JVI.02973-15.


A single amino-acid change in a highly conserved motif of gp41 elicits HIV-1 neutralization and protects against CD4 depletion.

Petitdemange C, Achour A, Dispinseri S, Malet I, Sennepin A, Ho Tsong Fang R, Crouzet J, Marcelin AG, Calvez V, Scarlatti G, Debré P, Vieillard V.

Clin Infect Dis. 2013 Sep;57(5):745-55. doi: 10.1093/cid/cit335. Epub 2013 May 21.


Functional activity of an HIV-1 neutralizing IgG human monoclonal antibody: ADCC and complement-mediated lysis.

Posner MR, Elboim HS, Cannon T, Cavacini L, Hideshima T.

AIDS Res Hum Retroviruses. 1992 May;8(5):553-8.


NK cell function and antibodies mediating ADCC in HIV-1-infected viremic and controller patients.

Johansson SE, Rollman E, Chung AW, Center RJ, Hejdeman B, Stratov I, Hinkula J, Wahren B, Kärre K, Kent SJ, Berg L.

Viral Immunol. 2011 Oct;24(5):359-68. doi: 10.1089/vim.2011.0025. Epub 2011 Sep 29.


The HIV-1 gp120 CD4-bound conformation is preferentially targeted by antibody-dependent cellular cytotoxicity-mediating antibodies in sera from HIV-1-infected individuals.

Veillette M, Coutu M, Richard J, Batraville LA, Dagher O, Bernard N, Tremblay C, Kaufmann DE, Roger M, Finzi A.

J Virol. 2015 Jan;89(1):545-51. doi: 10.1128/JVI.02868-14. Epub 2014 Oct 22.


Deficient antibody-dependent cellular cytotoxicity against human immunodeficiency virus (HIV)-expressing target cells in perinatal HIV infection.

Ziegner U, Campbell D, Weinhold K, Frank I, Rutstein R, Starr SE.

Clin Diagn Lab Immunol. 1999 Sep;6(5):718-24.


Reconstitution and characterization of antibody repertoires of HIV-1-infected "elite neutralizers".

Sun Z, Li J, Hu X, Shao Y, Zhang MY.

Antiviral Res. 2015 Jun;118:1-9. doi: 10.1016/j.antiviral.2015.02.006. Epub 2015 Mar 12.


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