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Items: 1 to 20 of 260

1.

Post-transcriptional regulation of O(6)-methylguanine-DNA methyltransferase MGMT in glioblastomas.

Ramakrishnan V, Kushwaha D, Koay DC, Reddy H, Mao Y, Zhou L, Ng K, Zinn P, Carter B, Chen CC.

Cancer Biomark. 2011-2012;10(3-4):185-93. doi: 10.3233/CBM-2012-0245.

PMID:
22674304
2.

O-methylguanine-DNA methyltransferase (MGMT) mRNA expression predicts outcome in malignant glioma independent of MGMT promoter methylation.

Kreth S, Thon N, Eigenbrod S, Lutz J, Ledderose C, Egensperger R, Tonn JC, Kretzschmar HA, Hinske LC, Kreth FW.

PLoS One. 2011 Feb 18;6(2):e17156. doi: 10.1371/journal.pone.0017156.

3.

In human glioblastomas transcript elongation by alternative polyadenylation and miRNA targeting is a potent mechanism of MGMT silencing.

Kreth S, Limbeck E, Hinske LC, Schütz SV, Thon N, Hoefig K, Egensperger R, Kreth FW.

Acta Neuropathol. 2013 May;125(5):671-81. doi: 10.1007/s00401-013-1081-1. Epub 2013 Jan 23.

PMID:
23340988
4.

Alterations in S-adenosylhomocysteine metabolism decrease O6-methylguanine DNA methyltransferase gene expression without affecting promoter methylation.

Hermes M, Geisler H, Osswald H, Riehle R, Kloor D.

Biochem Pharmacol. 2008 Jun 1;75(11):2100-11. doi: 10.1016/j.bcp.2008.02.031. Epub 2008 Mar 8.

PMID:
18395186
5.

Influence of CpG island methylation status in O6-methylguanine-DNA methyltransferase expression of oral cancer cell lines.

Murakami J, Asaumi J, Maki Y, Tsujigiwa H, Nagatsuka H, Kokeguchi S, Inoue T, Kawasaki S, Tanaka N, MacPhee D, Matsubara N, Kishi K.

Oncol Rep. 2004 Aug;12(2):339-45.

PMID:
15254699
6.

Correlation of MGMT promoter methylation status with gene and protein expression levels in glioblastoma.

Uno M, Oba-Shinjo SM, Camargo AA, Moura RP, Aguiar PH, Cabrera HN, Begnami M, Rosemberg S, Teixeira MJ, Marie SK.

Clinics (Sao Paulo). 2011;66(10):1747-55.

7.

A distinct region of the MGMT CpG island critical for transcriptional regulation is preferentially methylated in glioblastoma cells and xenografts.

Malley DS, Hamoudi RA, Kocialkowski S, Pearson DM, Collins VP, Ichimura K.

Acta Neuropathol. 2011 May;121(5):651-61. doi: 10.1007/s00401-011-0803-5. Epub 2011 Feb 3.

PMID:
21287394
8.

Correlation of O6-methylguanine methyltransferase (MGMT) promoter methylation with clinical outcomes in glioblastoma and clinical strategies to modulate MGMT activity.

Hegi ME, Liu L, Herman JG, Stupp R, Wick W, Weller M, Mehta MP, Gilbert MR.

J Clin Oncol. 2008 Sep 1;26(25):4189-99. doi: 10.1200/JCO.2007.11.5964. Review.

9.

Prognostic significance of O6-methylguanine-DNA methyltransferase determined by promoter hypermethylation and immunohistochemical expression in anaplastic gliomas.

Brell M, Tortosa A, Verger E, Gil JM, Viñolas N, Villá S, Acebes JJ, Caral L, Pujol T, Ferrer I, Ribalta T, Graus F.

Clin Cancer Res. 2005 Jul 15;11(14):5167-74.

10.

A methylation-specific and SYBR-green-based quantitative polymerase chain reaction technique for O6-methylguanine DNA methyltransferase promoter methylation analysis.

Hattermann K, Mehdorn HM, Mentlein R, Schultka S, Held-Feindt J.

Anal Biochem. 2008 Jun 1;377(1):62-71. doi: 10.1016/j.ab.2008.03.014. Epub 2008 Mar 14.

PMID:
18384736
11.

MGMT promoter hypermethylation in a series of 104 glioblastomas.

Mellai M, Caldera V, Annovazzi L, Chiò A, Lanotte M, Cassoni P, Finocchiaro G, Schiffer D.

Cancer Genomics Proteomics. 2009 Jul-Aug;6(4):219-27.

12.

Prognostic impact of O6-methylguanine-DNA methyltransferase silencing in patients with recurrent glioblastoma multiforme who undergo surgery and carmustine wafer implantation: a prospective patient cohort.

Metellus P, Coulibaly B, Nanni I, Fina F, Eudes N, Giorgi R, Barrie M, Chinot O, Fuentes S, Dufour H, Ouafik L, Figarella-Branger D.

Cancer. 2009 Oct 15;115(20):4783-94. doi: 10.1002/cncr.24546.

13.

Glycogen synthase kinase 3β inhibition sensitizes human glioblastoma cells to temozolomide by affecting O6-methylguanine DNA methyltransferase promoter methylation via c-Myc signaling.

Pyko IV, Nakada M, Sabit H, Teng L, Furuyama N, Hayashi Y, Kawakami K, Minamoto T, Fedulau AS, Hamada J.

Carcinogenesis. 2013 Oct;34(10):2206-17. doi: 10.1093/carcin/bgt182. Epub 2013 May 28.

PMID:
23715499
14.

Identification of regions correlating MGMT promoter methylation and gene expression in glioblastomas.

Everhard S, Tost J, El Abdalaoui H, Crinière E, Busato F, Marie Y, Gut IG, Sanson M, Mokhtari K, Laigle-Donadey F, Hoang-Xuan K, Delattre JY, Thillet J.

Neuro Oncol. 2009 Aug;11(4):348-56. doi: 10.1215/15228517-2009-001. Epub 2009 Feb 17.

15.

Tumor progression through epigenetic gene silencing of O(6)-methylguanine-DNA methyltransferase in human biliary tract cancers.

Koga Y, Kitajima Y, Miyoshi A, Sato K, Kitahara K, Soejima H, Miyazaki K.

Ann Surg Oncol. 2005 May;12(5):354-63. Epub 2005 Mar 31.

PMID:
15915369
16.

Promoter methylation of the DNA repair gene MGMT in astrocytomas is frequently associated with G:C --> A:T mutations of the TP53 tumor suppressor gene.

Nakamura M, Watanabe T, Yonekawa Y, Kleihues P, Ohgaki H.

Carcinogenesis. 2001 Oct;22(10):1715-9.

PMID:
11577014
17.

Clinical trial substantiates the predictive value of O-6-methylguanine-DNA methyltransferase promoter methylation in glioblastoma patients treated with temozolomide.

Hegi ME, Diserens AC, Godard S, Dietrich PY, Regli L, Ostermann S, Otten P, Van Melle G, de Tribolet N, Stupp R.

Clin Cancer Res. 2004 Mar 15;10(6):1871-4.

18.

Correlation between quantified promoter methylation and enzymatic activity of O6-methylguanine-DNA methyltransferase in glioblastomas.

Kishida Y, Natsume A, Toda H, Toi Y, Motomura K, Koyama H, Matsuda K, Nakayama O, Sato M, Suzuki M, Kondo Y, Wakabayashi T.

Tumour Biol. 2012 Apr;33(2):373-81. doi: 10.1007/s13277-012-0319-1. Epub 2012 Jan 26.

PMID:
22274924
19.

O6-Methylguanine-DNA methyltransferase is a novel negative effector of invasion in glioblastoma multiforme.

Chahal M, Abdulkarim B, Xu Y, Guiot MC, Easaw JC, Stifani N, Sabri S.

Mol Cancer Ther. 2012 Nov;11(11):2440-50. doi: 10.1158/1535-7163.MCT-11-0977. Epub 2012 Sep 17.

20.

Promoter methylation and polymorphisms of the MGMT gene in glioblastomas: a population-based study.

Zawlik I, Vaccarella S, Kita D, Mittelbronn M, Franceschi S, Ohgaki H.

Neuroepidemiology. 2009;32(1):21-9. doi: 10.1159/000170088. Epub 2008 Nov 8.

PMID:
18997474

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