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Items: 1 to 20 of 106


An S-opsin knock-in mouse (F81Y) reveals a role for the native ligand 11-cis-retinal in cone opsin biosynthesis.

Insinna C, Daniele LL, Davis JA, Larsen DD, Kuemmel C, Wang J, Nikonov SS, Knox BE, Pugh EN Jr.

J Neurosci. 2012 Jun 6;32(23):8094-104. doi: 10.1523/JNEUROSCI.0131-12.2012.


Cone opsin mislocalization in Rpe65-/- mice: a defect that can be corrected by 11-cis retinal.

Rohrer B, Lohr HR, Humphries P, Redmond TM, Seeliger MW, Crouch RK.

Invest Ophthalmol Vis Sci. 2005 Oct;46(10):3876-82.


Trafficking of membrane-associated proteins to cone photoreceptor outer segments requires the chromophore 11-cis-retinal.

Zhang H, Fan J, Li S, Karan S, Rohrer B, Palczewski K, Frederick JM, Crouch RK, Baehr W.

J Neurosci. 2008 Apr 9;28(15):4008-14. doi: 10.1523/JNEUROSCI.0317-08.2008. Erratum in: J Neurosci. 2008 Nov 5;28(45):11741.


Protection of cone photoreceptor M-opsin degradation with 9-cis-β-carotene-rich alga Dunaliella bardawil in Rpe65(-/-) mouse retinal explant culture.

Ozaki T, Nakazawa M, Kudo T, Hirano S, Suzuki K, Ishiguro S.

Curr Eye Res. 2014 Dec;39(12):1221-31. doi: 10.3109/02713683.2014.907430.


Cone outer segment morphology and cone function in the Rpe65-/- Nrl-/- mouse retina are amenable to retinoid replacement.

Kunchithapautham K, Coughlin B, Crouch RK, Rohrer B.

Invest Ophthalmol Vis Sci. 2009 Oct;50(10):4858-64. doi: 10.1167/iovs.08-3008.


Nrl-knockout mice deficient in Rpe65 fail to synthesize 11-cis retinal and cone outer segments.

Feathers KL, Lyubarsky AL, Khan NW, Teofilo K, Swaroop A, Williams DS, Pugh EN Jr, Thompson DA.

Invest Ophthalmol Vis Sci. 2008 Mar;49(3):1126-35. doi: 10.1167/iovs.07-1234.


A mouse M-opsin monochromat: retinal cone photoreceptors have increased M-opsin expression when S-opsin is knocked out.

Daniele LL, Insinna C, Chance R, Wang J, Nikonov SS, Pugh EN Jr.

Vision Res. 2011 Feb 23;51(4):447-58. doi: 10.1016/j.visres.2010.12.017.


Effective and sustained delivery of hydrophobic retinoids to photoreceptors.

Tang PH, Fan J, Goletz PW, Wheless L, Crouch RK.

Invest Ophthalmol Vis Sci. 2010 Nov;51(11):5958-64. doi: 10.1167/iovs.10-5766.


Retinal cone photoreceptors of the deer mouse Peromyscus maniculatus: development, topography, opsin expression and spectral tuning.

Arbogast P, Glösmann M, Peichl L.

PLoS One. 2013 Nov 15;8(11):e80910. doi: 10.1371/journal.pone.0080910.


Rpe65-/- and Lrat-/- mice: comparable models of leber congenital amaurosis.

Fan J, Rohrer B, Frederick JM, Baehr W, Crouch RK.

Invest Ophthalmol Vis Sci. 2008 Jun;49(6):2384-9. doi: 10.1167/iovs.08-1727.


A 221-bp fragment of the mouse opsin promoter directs expression specifically to the rod photoreceptors of transgenic mice.

Quiambao AB, Peachey NS, Mangini NJ, Röhlich P, Hollyfield JG, al-Ubaidi MR.

Vis Neurosci. 1997 Jul-Aug;14(4):617-25.


The murine cone photoreceptor: a single cone type expresses both S and M opsins with retinal spatial patterning.

Applebury ML, Antoch MP, Baxter LC, Chun LL, Falk JD, Farhangfar F, Kage K, Krzystolik MG, Lyass LA, Robbins JT.

Neuron. 2000 Sep;27(3):513-23.


In conditions of limited chromophore supply rods entrap 11-cis-retinal leading to loss of cone function and cell death.

Samardzija M, Tanimoto N, Kostic C, Beck S, Oberhauser V, Joly S, Thiersch M, Fahl E, Arsenijevic Y, von Lintig J, Wenzel A, Seeliger MW, Grimm C.

Hum Mol Genet. 2009 Apr 1;18(7):1266-75. doi: 10.1093/hmg/ddp026. Erratum in: Hum Mol Genet. 2011 Feb 1;20(3):628.


Cone opsin determines the time course of cone photoreceptor degeneration in Leber congenital amaurosis.

Zhang T, Zhang N, Baehr W, Fu Y.

Proc Natl Acad Sci U S A. 2011 May 24;108(21):8879-84. doi: 10.1073/pnas.1017127108.


Downregulation of cone-specific gene expression and degeneration of cone photoreceptors in the Rpe65-/- mouse at early ages.

Znoiko SL, Rohrer B, Lu K, Lohr HR, Crouch RK, Ma JX.

Invest Ophthalmol Vis Sci. 2005 Apr;46(4):1473-9.


Developmental changes of cone opsin expression but not retinal morphology in the hypothyroid Pax8 knockout mouse.

Glaschke A, Glösmann M, Peichl L.

Invest Ophthalmol Vis Sci. 2010 Mar;51(3):1719-27. doi: 10.1167/iovs.09-3592.


Light prevents exogenous 11-cis retinal from maintaining cone photoreceptors in chromophore-deficient mice.

Fan J, Crouch RK, Kono M.

Invest Ophthalmol Vis Sci. 2011 Apr 14;52(5):2412-6. doi: 10.1167/iovs.10-6437.


Genetic deletion of S-opsin prevents rapid cone degeneration in a mouse model of Leber congenital amaurosis.

Zhang T, Enemchukwu NO, Jones A, Wang S, Dennis E, Watt CB, Pugh EN Jr, Fu Y.

Hum Mol Genet. 2015 Mar 15;24(6):1755-63. doi: 10.1093/hmg/ddu588.

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