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Ubiquitination and phosphorylation of Beclin 1 and its binding partners: Tuning class III phosphatidylinositol 3-kinase activity and tumor suppression.

Abrahamsen H, Stenmark H, Platta HW.

FEBS Lett. 2012 Jun 4;586(11):1584-91. doi: 10.1016/j.febslet.2012.04.046. Epub 2012 May 3. Review.


A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic.

Thoresen SB, Pedersen NM, Liestøl K, Stenmark H.

Exp Cell Res. 2010 Dec 10;316(20):3368-78. doi: 10.1016/j.yexcr.2010.07.008. Epub 2010 Jul 17.


Nrbf2 protein suppresses autophagy by modulating Atg14L protein-containing Beclin 1-Vps34 complex architecture and reducing intracellular phosphatidylinositol-3 phosphate levels.

Zhong Y, Morris DH, Jin L, Patel MS, Karunakaran SK, Fu YJ, Matuszak EA, Weiss HL, Chait BT, Wang QJ.

J Biol Chem. 2014 Sep 19;289(38):26021-37. doi: 10.1074/jbc.M114.561134. Epub 2014 Aug 1.


Beclin 1 is required for neuron viability and regulates endosome pathways via the UVRAG-VPS34 complex.

McKnight NC, Zhong Y, Wold MS, Gong S, Phillips GR, Dou Z, Zhao Y, Heintz N, Zong WX, Yue Z.

PLoS Genet. 2014 Oct 2;10(10):e1004626. doi: 10.1371/journal.pgen.1004626. eCollection 2014 Oct.


Regulation of the Tumor-Suppressor Function of the Class III Phosphatidylinositol 3-Kinase Complex by Ubiquitin and SUMO.

Reidick C, El Magraoui F, Meyer HE, Stenmark H, Platta HW.

Cancers (Basel). 2014 Dec 23;7(1):1-29. doi: 10.3390/cancers7010001. Review.


Nedd4-dependent lysine-11-linked polyubiquitination of the tumour suppressor Beclin 1.

Platta HW, Abrahamsen H, Thoresen SB, Stenmark H.

Biochem J. 2012 Jan 1;441(1):399-406. doi: 10.1042/BJ20111424.


WASH inhibits autophagy through suppression of Beclin 1 ubiquitination.

Xia P, Wang S, Du Y, Zhao Z, Shi L, Sun L, Huang G, Ye B, Li C, Dai Z, Hou N, Cheng X, Sun Q, Li L, Yang X, Fan Z.

EMBO J. 2013 Oct 16;32(20):2685-96. doi: 10.1038/emboj.2013.189. Epub 2013 Aug 23.


The evolutionarily conserved domain of Beclin 1 is required for Vps34 binding, autophagy and tumor suppressor function.

Furuya N, Yu J, Byfield M, Pattingre S, Levine B.

Autophagy. 2005 Apr;1(1):46-52. Epub 2005 Apr 17.


Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG.

Itakura E, Kishi C, Inoue K, Mizushima N.

Mol Biol Cell. 2008 Dec;19(12):5360-72. doi: 10.1091/mbc.E08-01-0080. Epub 2008 Oct 8.


NRBF2 regulates macroautophagy as a component of Vps34 Complex I.

Cao Y, Wang Y, Abi Saab WF, Yang F, Pessin JE, Backer JM.

Biochem J. 2014 Jul 15;461(2):315-22. doi: 10.1042/BJ20140515.


The Beclin 1 network regulates autophagy and apoptosis.

Kang R, Zeh HJ, Lotze MT, Tang D.

Cell Death Differ. 2011 Apr;18(4):571-80. doi: 10.1038/cdd.2010.191. Epub 2011 Feb 11. Review.


Acetylated hsp70 and KAP1-mediated Vps34 SUMOylation is required for autophagosome creation in autophagy.

Yang Y, Fiskus W, Yong B, Atadja P, Takahashi Y, Pandita TK, Wang HG, Bhalla KN.

Proc Natl Acad Sci U S A. 2013 Apr 23;110(17):6841-6. doi: 10.1073/pnas.1217692110. Epub 2013 Apr 8.


Canonical autophagy dependent on the class III phosphoinositide-3 kinase Vps34 is required for naive T-cell homeostasis.

Willinger T, Flavell RA.

Proc Natl Acad Sci U S A. 2012 May 29;109(22):8670-5. doi: 10.1073/pnas.1205305109. Epub 2012 May 16.


Cul3-KLHL20 Ubiquitin Ligase Governs the Turnover of ULK1 and VPS34 Complexes to Control Autophagy Termination.

Liu CC, Lin YC, Chen YH, Chen CM, Pang LY, Chen HA, Wu PR, Lin MY, Jiang ST, Tsai TF, Chen RH.

Mol Cell. 2016 Jan 7;61(1):84-97. doi: 10.1016/j.molcel.2015.11.001. Epub 2015 Dec 10.


Dapper1 promotes autophagy by enhancing the Beclin1-Vps34-Atg14L complex formation.

Ma B, Cao W, Li W, Gao C, Qi Z, Zhao Y, Du J, Xue H, Peng J, Wen J, Chen H, Ning Y, Huang L, Zhang H, Gao X, Yu L, Chen YG.

Cell Res. 2014 Aug;24(8):912-24. doi: 10.1038/cr.2014.84. Epub 2014 Jul 1.


Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome.

Salminen A, Kaarniranta K, Kauppinen A, Ojala J, Haapasalo A, Soininen H, Hiltunen M.

Prog Neurobiol. 2013 Jul-Aug;106-107:33-54. doi: 10.1016/j.pneurobio.2013.06.002. Epub 2013 Jul 1. Review.


RACK1 Promotes Autophagy by Enhancing the Atg14L-Beclin 1-Vps34-Vps15 Complex Formation upon Phosphorylation by AMPK.

Zhao Y, Wang Q, Qiu G, Zhou S, Jing Z, Wang J, Wang W, Cao J, Han K, Cheng Q, Shen B, Chen Y, Zhang WJ, Ma Y, Zhang J.

Cell Rep. 2015 Nov 17;13(7):1407-17. doi: 10.1016/j.celrep.2015.10.011. Epub 2015 Nov 5.


FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation.

Xiao J, Zhang T, Xu D, Wang H, Cai Y, Jin T, Liu M, Jin M, Wu K, Yuan J.

Genes Dev. 2015 Jan 15;29(2):184-96. doi: 10.1101/gad.252528.114.


From a global view to focused examination: understanding cellular function of lipid kinase VPS34-Beclin 1 complex in autophagy.

Yue Z, Zhong Y.

J Mol Cell Biol. 2010 Dec;2(6):305-7. doi: 10.1093/jmcb/mjq028. Epub 2010 Sep 15.


The Beclin 1-VPS34 complex--at the crossroads of autophagy and beyond.

Funderburk SF, Wang QJ, Yue Z.

Trends Cell Biol. 2010 Jun;20(6):355-62. doi: 10.1016/j.tcb.2010.03.002. Epub 2010 Mar 29. Review.

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