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Items: 1 to 20 of 95

1.

Increased serum clearance of oligomannose species present on a human IgG1 molecule.

Alessandri L, Ouellette D, Acquah A, Rieser M, Leblond D, Saltarelli M, Radziejewski C, Fujimori T, Correia I.

MAbs. 2012 Jul-Aug;4(4):509-20. doi: 10.4161/mabs.20450. Epub 2012 Jul 1.

2.

High-mannose glycans on the Fc region of therapeutic IgG antibodies increase serum clearance in humans.

Goetze AM, Liu YD, Zhang Z, Shah B, Lee E, Bondarenko PV, Flynn GC.

Glycobiology. 2011 Jul;21(7):949-59. doi: 10.1093/glycob/cwr027. Epub 2011 Mar 18.

PMID:
21421994
3.

Comparison of biological activity among nonfucosylated therapeutic IgG1 antibodies with three different N-linked Fc oligosaccharides: the high-mannose, hybrid, and complex types.

Kanda Y, Yamada T, Mori K, Okazaki A, Inoue M, Kitajima-Miyama K, Kuni-Kamochi R, Nakano R, Yano K, Kakita S, Shitara K, Satoh M.

Glycobiology. 2007 Jan;17(1):104-18. Epub 2006 Sep 29. Erratum in: Glycobiology. 2007 Oct;17(10):1030.

PMID:
17012310
4.

Metabolic control of recombinant monoclonal antibody N-glycosylation in GS-NS0 cells.

Hills AE, Patel A, Boyd P, James DC.

Biotechnol Bioeng. 2001 Oct 20;75(2):239-51.

PMID:
11536148
5.

The effect of Fc glycan forms on human IgG2 antibody clearance in humans.

Chen X, Liu YD, Flynn GC.

Glycobiology. 2009 Mar;19(3):240-9. doi: 10.1093/glycob/cwn120. Epub 2008 Oct 30.

PMID:
18974198
6.

Site-specific N-glycosylation of chicken serum IgG.

Suzuki N, Lee YC.

Glycobiology. 2004 Mar;14(3):275-92. Epub 2003 Dec 23.

PMID:
14693911
7.

The criticality of high-resolution N-linked carbohydrate assays and detailed characterization of antibody effector function in the context of biosimilar development.

Brady LJ, Velayudhan J, Visone DB, Daugherty KC, Bartron JL, Coon M, Cornwall C, Hinckley PJ, Connell-Crowley L.

MAbs. 2015;7(3):562-70. doi: 10.1080/19420862.2015.1016692.

8.

N-glycan PK Profiling Using a High Sensitivity nanoLCMS Work-Flow with Heavy Stable Isotope Labeled Internal Standard and Application to a Preclinical Study of an IgG1 Biopharmaceutical.

Higel F, Seidl A, Demelbauer U, Viertlboeck-Schudy M, Koppenburg V, Kronthaler U, Sörgel F, Friess W.

Pharm Res. 2015 Nov;32(11):3649-59. doi: 10.1007/s11095-015-1724-0. Epub 2015 May 28.

9.

Effect of high mannose glycan pairing on IgG antibody clearance.

Liu YD, Flynn GC.

Biologicals. 2016 May;44(3):163-9. doi: 10.1016/j.biologicals.2016.02.003. Epub 2016 Mar 15.

PMID:
26992607
10.
11.

Impact of variable domain glycosylation on antibody clearance: an LC/MS characterization.

Huang L, Biolsi S, Bales KR, Kuchibhotla U.

Anal Biochem. 2006 Feb 15;349(2):197-207. Epub 2005 Nov 28.

PMID:
16360109
12.

Control of recombinant monoclonal antibody effector functions by Fc N-glycan remodeling in vitro.

Hodoniczky J, Zheng YZ, James DC.

Biotechnol Prog. 2005 Nov-Dec;21(6):1644-52.

PMID:
16321047
13.

The glycosylation of human serum IgD and IgE and the accessibility of identified oligomannose structures for interaction with mannan-binding lectin.

Arnold JN, Radcliffe CM, Wormald MR, Royle L, Harvey DJ, Crispin M, Dwek RA, Sim RB, Rudd PM.

J Immunol. 2004 Dec 1;173(11):6831-40.

14.

Human serum IgM glycosylation: identification of glycoforms that can bind to mannan-binding lectin.

Arnold JN, Wormald MR, Suter DM, Radcliffe CM, Harvey DJ, Dwek RA, Rudd PM, Sim RB.

J Biol Chem. 2005 Aug 12;280(32):29080-7. Epub 2005 Jun 14.

15.

Production, characterization, and pharmacokinetic properties of antibodies with N-linked mannose-5 glycans.

Yu M, Brown D, Reed C, Chung S, Lutman J, Stefanich E, Wong A, Stephan JP, Bayer R.

MAbs. 2012 Jul-Aug;4(4):475-87. doi: 10.4161/mabs.20737. Epub 2012 Jul 1.

16.

Quantitative glycan profiling of normal human plasma derived immunoglobulin and its fragments Fab and Fc.

Anumula KR.

J Immunol Methods. 2012 Aug 31;382(1-2):167-76. doi: 10.1016/j.jim.2012.05.022. Epub 2012 Jun 6.

PMID:
22683540
17.

Contrasting glycosylation profiles between Fab and Fc of a human IgG protein studied by electrospray ionization mass spectrometry.

Mimura Y, Ashton PR, Takahashi N, Harvey DJ, Jefferis R.

J Immunol Methods. 2007 Sep 30;326(1-2):116-26. Epub 2007 Aug 8.

PMID:
17714731
19.

Evaluation of an immunoassay for human-specific quantitation of therapeutic antibodies in serum samples from non-human primates.

Stubenrauch K, Wessels U, Lenz H.

J Pharm Biomed Anal. 2009 May 1;49(4):1003-8. doi: 10.1016/j.jpba.2009.01.030. Epub 2009 Feb 5.

PMID:
19250787
20.

A study of immunoglobulin G glycosylation in monoclonal and polyclonal species by electrospray and matrix-assisted laser desorption/ionization mass spectrometry.

Saba JA, Kunkel JP, Jan DC, Ens WE, Standing KG, Butler M, Jamieson JC, Perreault H.

Anal Biochem. 2002 Jun 1;305(1):16-31.

PMID:
12018942

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