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Items: 1 to 20 of 110

1.

The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities.

Lewerenz J, Hewett SJ, Huang Y, Lambros M, Gout PW, Kalivas PW, Massie A, Smolders I, Methner A, Pergande M, Smith SB, Ganapathy V, Maher P.

Antioxid Redox Signal. 2013 Feb 10;18(5):522-55. doi: 10.1089/ars.2011.4391. Epub 2012 Aug 3. Review.

2.

Structure, function, and regulation of human cystine/glutamate transporter in retinal pigment epithelial cells.

Bridges CC, Kekuda R, Wang H, Prasad PD, Mehta P, Huang W, Smith SB, Ganapathy V.

Invest Ophthalmol Vis Sci. 2001 Jan;42(1):47-54.

PMID:
11133847
3.

Mechanisms of oxidative glutamate toxicity: the glutamate/cystine antiporter system xc- as a neuroprotective drug target.

Albrecht P, Lewerenz J, Dittmer S, Noack R, Maher P, Methner A.

CNS Neurol Disord Drug Targets. 2010 Jul;9(3):373-82. Review.

PMID:
20053169
4.

The oxidative stress-inducible cystine/glutamate antiporter, system x (c) (-) : cystine supplier and beyond.

Conrad M, Sato H.

Amino Acids. 2012 Jan;42(1):231-46. doi: 10.1007/s00726-011-0867-5. Epub 2011 Mar 16. Review.

PMID:
21409388
5.

Expression and developmental regulation of the cystine/glutamate exchanger (xc-) in the rat.

La Bella V, Valentino F, Piccoli T, Piccoli F.

Neurochem Res. 2007 Jun;32(6):1081-90. Epub 2007 Mar 31.

PMID:
17401668
6.

Increased expression of cystine/glutamate antiporter in multiple sclerosis.

Pampliega O, Domercq M, Soria FN, Villoslada P, Rodríguez-Antigüedad A, Matute C.

J Neuroinflammation. 2011 Jun 3;8:63. doi: 10.1186/1742-2094-8-63.

7.

The x(c)- cystine/glutamate antiporter: a potential target for therapy of cancer and other diseases.

Lo M, Wang YZ, Gout PW.

J Cell Physiol. 2008 Jun;215(3):593-602. doi: 10.1002/jcp.21366. Review.

PMID:
18181196
8.

Regulation of xCT expression and system x (c) (-) function in neuronal cells.

Lewerenz J, Maher P, Methner A.

Amino Acids. 2012 Jan;42(1):171-9. doi: 10.1007/s00726-011-0862-x. Epub 2011 Mar 3. Review.

PMID:
21369940
9.

Expression of the activity of cystine/glutamate exchange transporter, system x(c)(-), by xCT and rBAT.

Wang H, Tamba M, Kimata M, Sakamoto K, Bannai S, Sato H.

Biochem Biophys Res Commun. 2003 Jun 6;305(3):611-8.

PMID:
12763038
10.
11.

The cystine/cysteine cycle: a redox cycle regulating susceptibility versus resistance to cell death.

Banjac A, Perisic T, Sato H, Seiler A, Bannai S, Weiss N, Kölle P, Tschoep K, Issels RD, Daniel PT, Conrad M, Bornkamm GW.

Oncogene. 2008 Mar 6;27(11):1618-28. Epub 2007 Sep 10.

PMID:
17828297
12.

Transcriptional control of cystine/glutamate transporter gene by amino acid deprivation.

Sato H, Nomura S, Maebara K, Sato K, Tamba M, Bannai S.

Biochem Biophys Res Commun. 2004 Dec 3;325(1):109-16.

PMID:
15522208
13.

Regulation of the system x(C)- cystine/glutamate exchanger by intracellular glutathione levels in rat astrocyte primary cultures.

Seib TM, Patel SA, Bridges RJ.

Glia. 2011 Oct;59(10):1387-401. doi: 10.1002/glia.21176. Epub 2011 May 17.

PMID:
21590811
14.

Glutamate, excitatory amino acid transporters, Xc- antiporter, glutamine synthetase, and gamma-glutamyltranspeptidase in human corneal epithelium.

Langford MP, Redmond P, Chanis R, Misra RP, Redens TB.

Curr Eye Res. 2010 Mar;35(3):202-11. doi: 10.3109/02713680903461489.

PMID:
20373878
15.

Transport of L-[14C]cystine and L-[14C]cysteine by subtypes of high affinity glutamate transporters over-expressed in HEK cells.

Hayes D, Wiessner M, Rauen T, McBean GJ.

Neurochem Int. 2005 Jun;46(8):585-94. Epub 2005 Apr 12.

PMID:
15863236
16.

System x(c)(-) regulates microglia and macrophage glutamate excitotoxicity in vivo.

Kigerl KA, Ankeny DP, Garg SK, Wei P, Guan Z, Lai W, McTigue DM, Banerjee R, Popovich PG.

Exp Neurol. 2012 Jan;233(1):333-41. doi: 10.1016/j.expneurol.2011.10.025. Epub 2011 Nov 4.

17.
18.

System xc⁻ cystine/glutamate antiporter: an update on molecular pharmacology and roles within the CNS.

Bridges RJ, Natale NR, Patel SA.

Br J Pharmacol. 2012 Jan;165(1):20-34. doi: 10.1111/j.1476-5381.2011.01480.x.

19.

Redox imbalance in cystine/glutamate transporter-deficient mice.

Sato H, Shiiya A, Kimata M, Maebara K, Tamba M, Sakakura Y, Makino N, Sugiyama F, Yagami K, Moriguchi T, Takahashi S, Bannai S.

J Biol Chem. 2005 Nov 11;280(45):37423-9. Epub 2005 Sep 6.

20.

Role of glutamate transporters in the regulation of glutathione levels in human macrophages.

Rimaniol AC, Mialocq P, Clayette P, Dormont D, Gras G.

Am J Physiol Cell Physiol. 2001 Dec;281(6):C1964-70.

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