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Items: 1 to 20 of 87

1.

A common missense variant in the ATP receptor P2X7 is associated with reduced risk of cardiovascular events.

Gidlöf O, Smith JG, Melander O, Lövkvist H, Hedblad B, Engström G, Nilsson P, Carlson J, Berglund G, Olsson S, Jood K, Jern C, Norrving B, Lindgren A, Erlinge D.

PLoS One. 2012;7(5):e37491. doi: 10.1371/journal.pone.0037491. Epub 2012 May 25.

2.

Association of P2X7 receptor polymorphisms with bone mineral density and osteoporosis risk in a cohort of Dutch fracture patients.

Wesselius A, Bours MJ, Henriksen Z, Syberg S, Petersen S, Schwarz P, Jørgensen NR, van Helden S, Dagnelie PC.

Osteoporos Int. 2013 Apr;24(4):1235-46. doi: 10.1007/s00198-012-2059-x. Epub 2012 Jul 10.

3.

A rare functional haplotype of the P2RX4 and P2RX7 genes leads to loss of innate phagocytosis and confers increased risk of age-related macular degeneration.

Gu BJ, Baird PN, Vessey KA, Skarratt KK, Fletcher EL, Fuller SJ, Richardson AJ, Guymer RH, Wiley JS.

FASEB J. 2013 Apr;27(4):1479-87. doi: 10.1096/fj.12-215368. Epub 2013 Jan 9.

PMID:
23303206
4.

Haplotypes of P2RX7 gene polymorphisms are associated with both cold pain sensitivity and analgesic effect of fentanyl.

Ide S, Nishizawa D, Fukuda K, Kasai S, Hasegawa J, Hayashida M, Minami M, Ikeda K.

Mol Pain. 2014 Dec 3;10:75. doi: 10.1186/1744-8069-10-75.

5.

Gain and loss of function of P2X7 receptors: mechanisms, pharmacology and relevance to diabetic neuropathic pain.

Ursu D, Ebert P, Langron E, Ruble C, Munsie L, Zou W, Fijal B, Qian YW, McNearney TA, Mogg A, Grubisha O, Merchant K, Sher E.

Mol Pain. 2014 Jun 16;10:37. doi: 10.1186/1744-8069-10-37.

6.

Effects of genetic variation in the P2RX7 gene on pharmacodynamics of a P2X(7) receptor antagonist: a prospective genotyping approach.

McHugh SM, Roman S, Davis B, Koch A, Pickett AM, Richardson JC, Miller SR, Wetten S, Cox CJ, Karpe F, Todd JA, Bullmore ET.

Br J Clin Pharmacol. 2012 Aug;74(2):376-80. doi: 10.1111/j.1365-2125.2012.04200.x.

7.

Single nucleotide polymorphisms that were identified in affective mood disorders affect ATP-activated P2X7 receptor functions.

Roger S, Mei ZZ, Baldwin JM, Dong L, Bradley H, Baldwin SA, Surprenant A, Jiang LH.

J Psychiatr Res. 2010 Apr;44(6):347-55. doi: 10.1016/j.jpsychires.2009.10.005. Epub 2009 Nov 20.

PMID:
19931869
8.

Variation in glucose homeostasis traits associated with P2RX7 polymorphisms in mice and humans.

Todd JN, Poon W, Lyssenko V, Groop L, Nichols B, Wilmot M, Robson S, Enjyoji K, Herman MA, Hu C, Zhang R, Jia W, Ma R, Florez JC, Friedman DJ.

J Clin Endocrinol Metab. 2015 May;100(5):E688-96. doi: 10.1210/jc.2014-4160. Epub 2015 Feb 26.

9.

The role of purinergic signaling in depressive disorders.

Sperlagh B, Csolle C, Ando RD, Goloncser F, Kittel A, Baranyi M.

Neuropsychopharmacol Hung. 2012 Dec;14(4):231-8. Review.

10.

A rare P2X7 variant Arg307Gln with absent pore formation function protects against neuroinflammation in multiple sclerosis.

Gu BJ, Field J, Dutertre S, Ou A, Kilpatrick TJ, Lechner-Scott J, Scott R, Lea R, Taylor BV, Stankovich J, Butzkueven H, Gresle M, Laws SM, Petrou S, Hoffjan S, Akkad DA, Graham CA, Hawkins S, Glaser A, Bedri SK, Hillert J, Matute C, Antiguedad A; ANZgene Consortium, Wiley JS.

Hum Mol Genet. 2015 Oct 1;24(19):5644-54. doi: 10.1093/hmg/ddv278. Epub 2015 Jul 17.

PMID:
26188005
11.

Functional polymorphisms in the P2X7 receptor gene are associated with osteoporosis.

Husted LB, Harsløf T, Stenkjær L, Carstens M, Jørgensen NR, Langdahl BL.

Osteoporos Int. 2013 Mar;24(3):949-59. doi: 10.1007/s00198-012-2035-5. Epub 2012 Jun 16.

PMID:
22707062
12.

The His155Tyr (489C>T) single nucleotide polymorphism of P2RX7 gene confers an enhanced function of P2X7 receptor in immune cells from patients with rheumatoid arthritis.

Portales-Cervantes L, Niño-Moreno P, Salgado-Bustamante M, García-Hernández MH, Baranda-Candido L, Reynaga-Hernández E, Barajas-López C, González-Amaro R, Portales-Pérez DP.

Cell Immunol. 2012 Mar-Apr;276(1-2):168-75. doi: 10.1016/j.cellimm.2012.05.005. Epub 2012 May 18.

PMID:
22703695
13.

Associations between depression severity and purinergic receptor P2RX7 gene polymorphisms.

Halmai Z, Dome P, Vereczkei A, Abdul-Rahman O, Szekely A, Gonda X, Faludi G, Sasvari-Szekely M, Nemoda Z.

J Affect Disord. 2013 Aug 15;150(1):104-9. doi: 10.1016/j.jad.2013.02.033. Epub 2013 Apr 18.

PMID:
23602648
14.

Analysis of single nucleotide polymorphisms in genes in the chromosome 12Q24.31 region points to P2RX7 as a susceptibility gene to bipolar affective disorder.

Barden N, Harvey M, Gagné B, Shink E, Tremblay M, Raymond C, Labbé M, Villeneuve A, Rochette D, Bordeleau L, Stadler H, Holsboer F, Müller-Myhsok B.

Am J Med Genet B Neuropsychiatr Genet. 2006 Jun 5;141B(4):374-82.

PMID:
16673375
15.

Residues 155 and 348 contribute to the determination of P2X7 receptor function via distinct mechanisms revealed by single-nucleotide polymorphisms.

Bradley HJ, Baldwin JM, Goli GR, Johnson B, Zou J, Sivaprasadarao A, Baldwin SA, Jiang LH.

J Biol Chem. 2011 Mar 11;286(10):8176-87. doi: 10.1074/jbc.M110.211284. Epub 2011 Jan 4.

16.

The effect of P2X7 receptor 1513 polymorphism on susceptibility to tuberculosis: A meta-analysis.

Wu G, Zhao M, Gu X, Yao Y, Liu H, Song Y.

Infect Genet Evol. 2014 Jun;24:82-91. doi: 10.1016/j.meegid.2014.03.006. Epub 2014 Mar 17. Review.

PMID:
24650918
17.

Functional polymorphisms in the P2X7 receptor gene are associated with stress fracture injury.

Varley I, Greeves JP, Sale C, Friedman E, Moran DS, Yanovich R, Wilson PJ, Gartland A, Hughes DC, Stellingwerff T, Ranson C, Fraser WD, Gallagher JA.

Purinergic Signal. 2016 Mar;12(1):103-13. doi: 10.1007/s11302-016-9495-6. Epub 2016 Jan 29.

18.

P2X7 receptor gene polymorphism analysis in rheumatoid arthritis.

Al-Shukaili A, Al-Kaabi J, Hassan B, Al-Araimi T, Al-Tobi M, Al-Kindi M, Al-Maniri A, Al-Gheilani A, Al-Ansari A.

Int J Immunogenet. 2011 Oct;38(5):389-96. doi: 10.1111/j.1744-313X.2011.01019.x. Epub 2011 Jun 6.

PMID:
21645266
19.

Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity.

Sorge RE, Trang T, Dorfman R, Smith SB, Beggs S, Ritchie J, Austin JS, Zaykin DV, Vander Meulen H, Costigan M, Herbert TA, Yarkoni-Abitbul M, Tichauer D, Livneh J, Gershon E, Zheng M, Tan K, John SL, Slade GD, Jordan J, Woolf CJ, Peltz G, Maixner W, Diatchenko L, Seltzer Z, Salter MW, Mogil JS.

Nat Med. 2012 Mar 25;18(4):595-9. doi: 10.1038/nm.2710.

20.

The P2X(7) loss-of-function Glu496Ala polymorphism affects ex vivo cytokine release and protects against the cytotoxic effects of high ATP-levels.

Wesselius A, Bours MJ, Arts IC, Theunisz EH, Geusens P, Dagnelie PC.

BMC Immunol. 2012 Dec 4;13:64. doi: 10.1186/1471-2172-13-64.

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