Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 115


Nuclear factor-κB regulates βAPP and β- and γ-secretases differently at physiological and supraphysiological Aβ concentrations.

Chami L, Buggia-Prévot V, Duplan E, Del Prete D, Chami M, Peyron JF, Checler F.

J Biol Chem. 2012 Jul 13;287(29):24573-84. doi: 10.1074/jbc.M111.333054. Epub 2012 May 31. Erratum in: J Biol Chem. 2015 Dec 11;290(50):29758. Delprete, Dolores [corrected to Del Prete, Dolores]. J Biol Chem. 2013 Jul 5;288(27):19645.


NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42.

Buggia-Prevot V, Sevalle J, Rossner S, Checler F.

J Biol Chem. 2008 Apr 11;283(15):10037-47. doi: 10.1074/jbc.M706579200. Epub 2008 Feb 8.


Increased NF-κB signalling up-regulates BACE1 expression and its therapeutic potential in Alzheimer's disease.

Chen CH, Zhou W, Liu S, Deng Y, Cai F, Tone M, Tone Y, Tong Y, Song W.

Int J Neuropsychopharmacol. 2012 Feb;15(1):77-90. doi: 10.1017/S1461145711000149. Epub 2011 Feb 18.


Melatonin regulates the transcription of βAPP-cleaving secretases mediated through melatonin receptors in human neuroblastoma SH-SY5Y cells.

Panmanee J, Nopparat C, Chavanich N, Shukla M, Mukda S, Song W, Vincent B, Govitrapong P.

J Pineal Res. 2015 Oct;59(3):308-20. doi: 10.1111/jpi.12260. Epub 2015 Jul 18.


Amyloid-β protein (Aβ) Glu11 is the major β-secretase site of β-site amyloid-β precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Aβ Asp1 contributes to Alzheimer pathogenesis.

Deng Y, Wang Z, Wang R, Zhang X, Zhang S, Wu Y, Staufenbiel M, Cai F, Song W.

Eur J Neurosci. 2013 Jun;37(12):1962-9. doi: 10.1111/ejn.12235.


Leptin attenuates BACE1 expression and amyloid-β genesis via the activation of SIRT1 signaling pathway.

Marwarha G, Raza S, Meiers C, Ghribi O.

Biochim Biophys Acta. 2014 Sep;1842(9):1587-95. doi: 10.1016/j.bbadis.2014.05.015. Epub 2014 May 27.


Gadd153 and NF-κB crosstalk regulates 27-hydroxycholesterol-induced increase in BACE1 and β-amyloid production in human neuroblastoma SH-SY5Y cells.

Marwarha G, Raza S, Prasanthi JR, Ghribi O.

PLoS One. 2013 Aug 9;8(8):e70773. doi: 10.1371/journal.pone.0070773. eCollection 2013 Aug 9.


Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes.

Ly PT, Wu Y, Zou H, Wang R, Zhou W, Kinoshita A, Zhang M, Yang Y, Cai F, Woodgett J, Song W.

J Clin Invest. 2013 Jan;123(1):224-35. doi: 10.1172/JCI64516. Epub 2012 Dec 3.


Intracellular trafficking of presenilin 1 is regulated by beta-amyloid precursor protein and phospholipase D1.

Liu Y, Zhang YW, Wang X, Zhang H, You X, Liao FF, Xu H.

J Biol Chem. 2009 May 1;284(18):12145-52. doi: 10.1074/jbc.M808497200. Epub 2009 Mar 10.


Retention in endoplasmic reticulum 1 (RER1) modulates amyloid-β (Aβ) production by altering trafficking of γ-secretase and amyloid precursor protein (APP).

Park HJ, Shabashvili D, Nekorchuk MD, Shyqyriu E, Jung JI, Ladd TB, Moore BD, Felsenstein KM, Golde TE, Kim SH.

J Biol Chem. 2012 Nov 23;287(48):40629-40. doi: 10.1074/jbc.M112.418442. Epub 2012 Oct 5.


Beta-amyloid secretases and beta-amloid degrading enzyme expression in lens.

Li G, Percontino L, Sun Q, Qazi AS, Frederikse PH.

Mol Vis. 2003 May 1;9:179-83.


Acceleration of amyloidogenesis and memory impairment by estrogen deficiency through NF-κB dependent beta-secretase activation in presenilin 2 mutant mice.

Hwang CJ, Park MH, Choi MK, Choi JS, Oh KW, Hwang DY, Han SB, Hong JT.

Brain Behav Immun. 2016 Mar;53:113-22. doi: 10.1016/j.bbi.2015.11.013. Epub 2015 Nov 22.


Ginsenoside Rg1 attenuates β-amyloid generation via suppressing PPARγ-regulated BACE1 activity in N2a-APP695 cells.

Chen LM, Lin ZY, Zhu YG, Lin N, Zhang J, Pan XD, Chen XC.

Eur J Pharmacol. 2012 Jan 30;675(1-3):15-21. doi: 10.1016/j.ejphar.2011.11.039. Epub 2011 Dec 7.


S-palmitoylation of gamma-secretase subunits nicastrin and APH-1.

Cheng H, Vetrivel KS, Drisdel RC, Meckler X, Gong P, Leem JY, Li T, Carter M, Chen Y, Nguyen P, Iwatsubo T, Tomita T, Wong PC, Green WN, Kounnas MZ, Thinakaran G.

J Biol Chem. 2009 Jan 16;284(3):1373-84. doi: 10.1074/jbc.M806380200. Epub 2008 Nov 20.


Distinct transcriptional regulation and function of the human BACE2 and BACE1 genes.

Sun X, Wang Y, Qing H, Christensen MA, Liu Y, Zhou W, Tong Y, Xiao C, Huang Y, Zhang S, Liu X, Song W.

FASEB J. 2005 May;19(7):739-49.


Loss of cleavage at β'-site contributes to apparent increase in β-amyloid peptide (Aβ) secretion by β-secretase (BACE1)-glycosylphosphatidylinositol (GPI) processing of amyloid precursor protein.

Vetrivel KS, Barman A, Chen Y, Nguyen PD, Wagner SL, Prabhakar R, Thinakaran G.

J Biol Chem. 2011 Jul 22;286(29):26166-77. doi: 10.1074/jbc.M111.260471. Epub 2011 Jun 3.


Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.

Steiner H, Capell A, Leimer U, Haass C.

Eur Arch Psychiatry Clin Neurosci. 1999;249(6):266-70. Review.


Transcriptional and translational regulation of BACE1 expression--implications for Alzheimer's disease.

Rossner S, Sastre M, Bourne K, Lichtenthaler SF.

Prog Neurobiol. 2006 Jun;79(2):95-111. Epub 2006 Aug 14. Review.


Sorting nexin 12 interacts with BACE1 and regulates BACE1-mediated APP processing.

Zhao Y, Wang Y, Yang J, Wang X, Zhao Y, Zhang X, Zhang YW.

Mol Neurodegener. 2012 Jun 18;7:30. doi: 10.1186/1750-1326-7-30.


Alzheimer's β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of β-amyloid.

Chen Y, Huang X, Zhang YW, Rockenstein E, Bu G, Golde TE, Masliah E, Xu H.

J Neurosci. 2012 Aug 15;32(33):11390-5.

Supplemental Content

Support Center