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Items: 1 to 20 of 147

1.

A leap into the chemical space of protein-protein interaction inhibitors.

Villoutreix BO, Labbé CM, Lagorce D, Laconde G, Sperandio O.

Curr Pharm Des. 2012;18(30):4648-67. Review.

2.
3.

Targeting protein-protein interactions and fragment-based drug discovery.

Valkov E, Sharpe T, Marsh M, Greive S, Hyvönen M.

Top Curr Chem. 2012;317:145-79. doi: 10.1007/128_2011_265. Review.

PMID:
22006238
4.

Imbalance in chemical space: How to facilitate the identification of protein-protein interaction inhibitors.

Kuenemann MA, Labbé CM, Cerdan AH, Sperandio O.

Sci Rep. 2016 Apr 1;6:23815. doi: 10.1038/srep23815.

5.

[Chemical libraries dedicated to protein-protein interactions].

Sperandio O, Villoutreix BO, Morelli X, Roche P.

Med Sci (Paris). 2015 Mar;31(3):312-9. doi: 10.1051/medsci/20153103017. Epub 2015 Apr 8. Review. French.

6.

Small-molecule stabilization of protein-protein interactions: an underestimated concept in drug discovery?

Thiel P, Kaiser M, Ottmann C.

Angew Chem Int Ed Engl. 2012 Feb 27;51(9):2012-8. doi: 10.1002/anie.201107616. Epub 2012 Feb 3. Review.

PMID:
22308055
7.

Protein-protein interactions: network analysis and applications in drug discovery.

Bultinck J, Lievens S, Tavernier J.

Curr Pharm Des. 2012;18(30):4619-29. Review.

PMID:
22650261
8.

Using fragment-based technologies to target protein-protein interactions.

Bower JF, Pannifer A.

Curr Pharm Des. 2012;18(30):4685-96. Review.

PMID:
22650253
9.

Focused chemical libraries--design and enrichment: an example of protein-protein interaction chemical space.

Zhang X, Betzi S, Morelli X, Roche P.

Future Med Chem. 2014 Jul;6(11):1291-307. doi: 10.4155/fmc.14.57. Epub 2014 Apr 28. Review.

PMID:
24773599
10.

Protein-protein interactions as new targets for drug design: virtual and experimental approaches.

Ivanov AS, Gnedenko OV, Molnar AA, Mezentsev YV, Lisitsa AV, Archakov AI.

J Bioinform Comput Biol. 2007 Apr;5(2B):579-92.

PMID:
17636863
11.

Hot spot-based design of small-molecule inhibitors for protein-protein interactions.

Guo W, Wisniewski JA, Ji H.

Bioorg Med Chem Lett. 2014 Jun 1;24(11):2546-54. doi: 10.1016/j.bmcl.2014.03.095. Epub 2014 Apr 5. Erratum in: Bioorg Med Chem Lett. 2014 Aug 1;24(15):3652.

12.

Development of a rule-based method for the assessment of protein druggability.

Perola E, Herman L, Weiss J.

J Chem Inf Model. 2012 Apr 23;52(4):1027-38. doi: 10.1021/ci200613b. Epub 2012 Apr 9.

PMID:
22448735
13.

Ligand specificity, privileged substructures and protein druggability from fragment-based screening.

Barelier S, Krimm I.

Curr Opin Chem Biol. 2011 Aug;15(4):469-74. doi: 10.1016/j.cbpa.2011.02.020. Epub 2011 Mar 14. Review.

PMID:
21411360
14.
15.

Surfing the Protein-Protein Interaction Surface Using Docking Methods: Application to the Design of PPI Inhibitors.

Sable R, Jois S.

Molecules. 2015 Jun 23;20(6):11569-603. doi: 10.3390/molecules200611569. Review.

16.

Discovery of small molecule inhibitors of protein-protein interactions using combined ligand and target score normalization.

Casey FP, Pihan E, Shields DC.

J Chem Inf Model. 2009 Dec;49(12):2708-17. doi: 10.1021/ci900294x.

PMID:
19994847
17.

Advancing the kinase field: new targets and second generation inhibitors.

Laufer S, Bajorath J.

J Med Chem. 2015 Jan 8;58(1):1. doi: 10.1021/jm5018708. Epub 2014 Dec 9. No abstract available.

PMID:
25490234
18.

Protein-protein interactions as druggable targets: recent technological advances.

Higueruelo AP, Jubb H, Blundell TL.

Curr Opin Pharmacol. 2013 Oct;13(5):791-6. doi: 10.1016/j.coph.2013.05.009. Epub 2013 Jun 1. Review.

PMID:
23735579
19.

In silico design of low molecular weight protein-protein interaction inhibitors: Overall concept and recent advances.

Kuenemann MA, Sperandio O, Labbé CM, Lagorce D, Miteva MA, Villoutreix BO.

Prog Biophys Mol Biol. 2015 Oct;119(1):20-32. doi: 10.1016/j.pbiomolbio.2015.02.006. Epub 2015 Mar 5. Review.

PMID:
25748546
20.

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